The Medicinal Chemistry Department seminars involve a mix of prominent researchers from both academic institutions and industry presenting research at the forefront of Medicinal Chemistry (broadly defined). They also include presentations from our own students (dissertation defenses & research seminars). The seminars are held on Thursday, weekly at 4:00pm in room 2548 NUB at the College of Pharmacy unless otherwise stated. Select a semester from the drop-down menu below to browse the schedule.

September 13, 2012
4:00pm
2548 CC Little
Mi Hee Lim, PhD
Assistant Professor
University of Michigan, Department of Chemistry

Small Molecules as Chemical Tools and Potential Therapeutics for Alzheimer's Disease


September 20, 2012
4:00pm
2548 CC Little
Gunda Georg, PhD
Professor and Department Head, Robert Vince Endowed Chair, McKnight Presidential Chair in Medicinal Chemistry
University of Minnesota

Academic drug discovery projects: Minnelide for pancreatic cancer chemotherapy and Gamendazole for male contraception


October 4, 2012
4:00pm
2548 CC Little
Victor Marquez, PhD
Rackham Centennial Speaker
Scientist Emeritus, National Cancer Institute

Conformationally Locked Nucleosides as Tools to Unlock Nature's Secrets


October 16, 2012
4:00pm
2548 CC Little
Elizabeth Girnys
PhD Candidate-Dissertation Defense
University of Michigan

Synthesis and Structure-Activity Relationships of Novel Direct Thrombin Inhibitors based on Pentapeptide FM 19


October 18, 2012
4:00pm
2548 CC Little
Steven J. Metallo, PhD
Associate Professor
Georgetown University, Department of Chemistry

Intrinsically disordered proteins as potential drug targets


October 25, 2012
4:00pm
2548 CC Little
Mark Kelley, PhD
Associate Director-Herman B. Wells Center for Pediatric Research
Indiana University School of Medicine

The DNA repair and redox signaling protein APE1/Ref-1: Target for cancer therapeutics, chemo-induced peripheral neuropathy and other indications


November 8, 2012
4:00pm
2548 CC Little
Paul L. Richardson, PhD
Principal Research Scientist
Abbott Laboratories; Chicago, IL

Modular Probes: Time-Resolved Fluorescence-Resonance Energy Transfer (TR-FRET) for High-Throughput Screening (HTS) and Other Applications


November 15, 2012
4:00pm
2548 CC Little
Ronald Breslow, PhD
John G. Topliss Lecture, Speaker
Professor of Chemistry and Biology, Columbia University

A Hypothesis-Driven Anticancer Path from Cells to Humans


December 11, 2012
4:00pm
2548 CC Little
Timor Baasov, PhD
Professor, Schulich Faculty of Chemistry in Technion
Israel Institute of Technology, Israel

To Fix Nature's Mistakes: Repairing Human Faulty Genes by Sugar-Based Small Molecules


January 7, 2013
4:00pm
2548 CC Little
Kamil Godula, PhD
Project Scientist,
Lawrence Berkeley National Laboratory

Synthetic Mucin Mimetics: Nanoscale Tools for Glycobiology


January 10, 2013
4:00pm
2548 CC Little
Tamara Hendrickson, PhD
Associate Professor, Department of Chemistry
Wayne State University

Discovery of new bacterial enzymes in protein biosynthesis


January 14, 2013
4:00pm
2548 CC Little
Amanda Garner, PhD
Senior Research Associate
Janda Laboratory, The Scripps Research Institute

Expanding the Scope of Organic Chemistry: Applications in Assay Design and Chemical Probe Discovery


January 17, 2013
4:00pm
2548 CC Little
Rachel A. Powers, PhD
Associate Professor of Chemistry
Grand Valley State University

Substrate specificity in class D β-lactamases: A structure based comparison of OXA-1 and OXA-24 with oxacillin bound


January 22, 2013
4:00pm
2548 CC Little
David Minh
Postdoctoral Research Associate
Duke University, Department of Chemistry

Computational Molecular Recognition - Prediction of Noncovalent Binding Affinities using Implicit Ligand Theory


January 24, 2013
4:00pm
2548 CC Little
Ron Jenkins
PhD Candidate-Dissertation Defense
University of Michigan

Phage Display as a Tool for Probing Lipid A Biosynthesis.


February 4, 2013
4:00pm
2548 CC Little
Jiaoyang Jiang, PhD
Postoctoral Fellow
Harvard Medical School

Mechanism, Inhibition & Proteolytic Activity of Human O-GlcNAc Transferase


February 28, 2013
4:00pm
2548 CC Little
Ching-Shih Chen, PhD
Professor of Medicinal Chemistry and Pharmacognosy
Ohio State University

Therapeutic Development Targeting Tumor Microenvironment


March 1, 2013
4:00pm
2548 CC Little
Peter Ung
Medicinal Chemistry Ph.D. Candidate
University of Michigan

Incorporation of Protein Flexibility in Structure-Based Drug Discovery of HIV-1 Protease and Bacterial Hsp70 Chaperone


March 14, 2013
4:00pm
2548 CC Little
Kevin D. Walker, PhD
Department of Chemistry
Michigan State University

Mechanisms of Enzymes Involved in the Biocatalysis of Paclitaxel


March 28, 2013
4:00pm
2548 CC Little
David Colby, PhD
Assistant Professor of Medicinal Chemistry
Purdue University

Synthesis and Biological Evaluation of Difluoromethyl Ketones as GABA agonists


April 11, 2013
4:00pm
2548 CC Little
William P. Schiemann
Co-Director and Associate Professor, Comprehensive Cancer Center
Case Western Reserve University

Oncogenic TGF-β Signaling and EMT Programs in Metastatic Breast Cancer


April 18, 2013
4:00pm
2548 CC Little
Charalampos (Babis) Kalodimos, PhD
Department of Chemistry and Chemical Biology
Rutgers University

Dynamic Activation of Protein Function


May 16, 2013
4:00pm
2548 CC Little
Gloria Komazin-Meredith, PhD
Leroy B. Townsend Symposium Lecturer
Senior Scientist, Microbiotix Inc

Methylenecyclopropane Analogues of Nucleosides as Broad Spectrum Anti-Herpes Agents


July 25, 2013
2pm
2548 CC Little
Jessica Anand
Medicinal Chemistry Ph. D. Candidate-Dissertation Defense
University of Michigan

The Mu and Delta Opioid Receptors: Mixed Efficacy Ligands and Receptor Trafficking

Faculty Host: Henry I. Mosberg ( him@umich.edu ) 764-8117
August 12, 2013
4:00pm
2548 CC Little
Kyle Bolduc
Medicinal Chemistry Ph. D. Candidate-Dissertation Defense
University of Michigan

Development of Synthetic and Biocatalytic Methods for the Chemoenzymatic Production of Novel Cryptophycin Anticancer Agents


August 15, 2013
4:00pm
2548 CC Little
Bryan Yestrepsky
Medicinal Chemistry Ph. D. Candidate-Dissertation Defense
University of Michigan

Development of a Novel Class of Multifunctional Virulence-Attenuating Antibiotics


September 3, 2013
2:30-3:30pm
2548 CC Little
Lauren Dixon Mishra
Medicinal Chemistry Ph.D. Candidate
University of Michigan

Molecular Recognition of small Molecules by Rho-associated Protein Kinase

Faculty Host: Gary D. Glick ( gglick@umich.edu ) 734-764-4548
October 31, 2013
4:00pm
2548 CC Little
Richard A. Gibbs, PhD
Associate Dean for Graduate Programs, Professor of Medicinal Chemistry and Molecular Pharmacology
Purdue University

Inhibitors of Isoprenylcysteine Carboxyl Methyltransferase as Potential Treatments for Pancreatic Cancer

Faculty Host: Matt Soellner ( soellner@umich.edu ) 734-615-2767
Speaker Website
November 14, 2013
4:00pm
2548 CC Little
Alejandra Yep-Rodriguez, PhD
Assistant Research Scientist, Department of Microbiology and Immunology University of Michigan
University of Michigan

A high-throughput screen for small molecule inhibitors of iron acquisition in uropathogenic E. coli

Faculty Host: Hollis Showalter ( showalh@umich.edu ) 734-764-5504
Speaker Website
November 21, 2013
4:00pm
2548 CC Little
Christopher M. Waters, PhD
Assistant Professor, Department of Microbiology and Molecular Genetics
Michigan State University

TBA Targeting cyclic di-GMP signaling to prevent bacterial biofilm formation

Faculty Host: Amanda Garner ( algarner@umich.edu ) 734-763-2654
Speaker Website
December 5, 2013
4:00pm
BSRB Kahn Auditorium
John G. Topliss Lecture-Paul S. Anderson, Ph.D.
Retired VP of Chemistry (Merck) and Senior VP for Drug Discovery (Bristol-Myers Squibb)

A Perspective on Drug Discovery

Faculty Host: Scott Larsen ( sdlarsen@umich.edu ) 734-615-0454
January 16, 2014
4:00pm
2548 CC Little
David Cech
MedChem Graduate Student, University of Michigan
Third Year Seminar

Structure, biochemical, and regulation studies of D-arabinose-5-phosphate isomerase


January 22, 2014
1:00 p.m.
Rackham Fourth Floor, East Conference Room
Fardohkt Abulwerdi
Medicinal Chemistry Ph.D. Candidate-Dissertation Defense
University of Michigan

Structure-based design, synthesis and evaluation of novel and selective small-molecule inhibitors of the anti-apoptotic protein Mcl-1

Faculty Host: Zaneta Nikolovska-Coleska and Hollis Showalter
January 23, 2014
4:00pm
2548 CC Little
Jordan Clark
MedChem Graduate Student, University of Michigan
Third Year Seminar

Inherent versus Induced Protein Flexibility


January 30, 2014
4:00pm
2548 CC Little
Chris Holt
MedChem Graduate Student, University of Michigan
Third Year Seminar

A Unique CMP-Kdo Synthetase from Shewanella Oneidensis


February 6, 2014
4:00pm
2548 CC Little
Taylor Johnson
MedChem Graduate Student, University of Michigan
Third Year Seminar

Using bivalent inhibitors to probe protein tyrosine kinase signaling in cells


February 13, 2014
4:00pm
2548 CC Little
Nathanael Gray, PhD
Professor of Biological Chemistry and Molecular Pharmacology
Harvard Medical School, Dana Farber Cancer Institute

TBA

Faculty Host: Matt Soellner ( soellner@umich.edu ) 734-615-2767
Speaker Website
February 20, 2014
4:00pm
2548 CC Little
Christine S. Chow, PhD
Professor and Associate Dean, Department of Chemistry
Wayne State University

TBA

Faculty Host: Amanda Garner ( algarner@umich.edu ) 734-763-2654
Speaker Website
February 27, 2014
4:00pm
2548 CC Little
Aaron Bender
MedChem Graduate Student, University of Michigan
Third Year Seminar

Synthesis of mixed efficacy opioid peptidomimetics


March 10, 2014
2:00 pm
Rackham Graduate School, East Conference Room, Fourth Floor
Kamali Sripathi
Medicinal Chemistry Ph.D. Candidate-Dissertation Defense
University of Michigan

Structural Dynamics of the Hepatitis Delta Virus and Hairpin Ribozymes: Implications for Function

Faculty Host: Nils Walter, Ph.D. ( nwalter@umich.edu )
March 13, 2014
4:00pm
2548 CC Little
Michael J. McLeish, PhD
Associate Professor, Chemistry, Department of Chemistry and Chemical Biology
Indiana University-Purdue University, Indianapolis

TBA


Speaker Website
March 27, 2014
4:00pm
2548 CC Little
Tim S. Bugni, PhD
Assistant Professor, Division of Pharmaceutical Sciences
School of Pharmacy; University of Wisconsin, Madison

Metabolomics for Natural Products Discovery and Library Design

Faculty Host: David Sherman ( davidhs@umich.edu ) 734-615-9907
Speaker Website
April 10, 2014
4:00pm
2548 CC Little
Dr. Clifton Barry III, PhD
Section Chief and Senior Investigator (Tenured), Tuberculosis Research Section, National Institute of Allergy and Infectious Diseases
National Institutes of Health

The evolution of rifampicin resistance in Mycobacterium tuberculosis: fitness and compensation

Faculty Host: George Garcia ( gagarcia@umich.edu ) 734-764-2202 Student Host: Max Stefan ( mastefan@umich.edu ) 734-647-3239
Speaker Website
April 17, 2014
4:00pm
2548 CC Little
Dennis C. Liotta, PhD
Samuel Candler Dobbs Professor
Department of Chemistry, Emory University

The Role of CXCR4 Modulators in Controlling HIV Entry, Stem Cell Mobilization and Certain Types of Cancer

Faculty Host: Shaomeng Wang ( shaomeng@umich.edu ) 734-615-0632
Speaker Website Speaker Abstract
May 22, 2014
Lecture: 11:00am, Reception Preceding Lecture: 10:15am
Lecture Location:1544 CC Little Bldg.; Reception Location: College of Pharmacy Front Lobby, 428 Church St.
Geoffrey C. Hoops, Ph.D.; Ninth Annual Leroy B. Townsend Symposium
Professor, Chemistry Department
Butler University

Probing the Enzymatic Activity of the Rv0045c Esterase from M. Tuberculosis: A Research Model for Undergraduate Biochemistry Education

Faculty Host: George A. Garcia ( gagarcia@umich.edu ) 647-8429
Speaker Website Speaker Abstract
July 2, 2014
4:00pm
2548 CC Little
Ghanakota Venkateshwar Rao, PhD
The Chairman, Board of Studies in Chemistry and Biochemistry and Professor of Organic Chemistry
Departments of Chemistry and Biochemistry, Kakatiya University, Warangal, Telangana, India

Microbial degradation of aromatic organic pollutants – A study of dead-end metabolites including the stereochemical mechanistic studies of cycloisomerase enzyme and their products using deuterium labelled precursors

Faculty Host: Heather Carlson ( carlsonh@umich.edu ) 615-6841 Student Host: Phani Ghanakota ( gphani@umich.edu )
Speaker Abstract
July 29, 2014
2:00 pm
2548 CC Little
Leah Makley
Medicinal Chemistry Ph.D. Candidate
University of Michigan

Oral Dissertation Defense, "Chemical Approaches for ‘Undruggable’ Targets: The Discovery of Ligands for Small Heat Shock Proteins."

Faculty Host: Jason Gestwicki and Heather Carlson ( carlsonh@umich.edu ) 615-6841
August 6, 2014
10:00am
1544 CC Little Building
Meghan E. Breen
Medicinal Chemistry Ph.D. Candidate
University of Michigan

Oral Dissertation Defense,"Substrate-Competitive Inhibitors of c-Src Kinase"

Faculty Host: Matt Soellner ( soellner@umich.edu ) 615-2767
August 20, 2014
1:00pm
2548 CC Little
Scott Barraza
Medicinal Chemistry Ph.D. Candidate
University of Michigan

Oral Dissertation Defense, "Development of Novel Small Molecule Inhibitors of Neurotropic Alphavirus Replication"

Faculty Host: Scott Larsen ( sdlarsen@umich.edu ) 615-0454
August 28, 2014
3:00pm
2548 CC Little
Janice Sindac
Medicinal Chemistry Ph.D. Candidate
University of Michigan

Oral Dissertation Defense, "Development of Small Molecule Inhibitors of Western Equine Encephalitis Virus Replication"

Faculty Host: Scott Larsen ( sdlarsen@umich.edu ) 615-0454
September 25, 2014
4:00pm
2548 CC Little
Kim D. Janda, PhD
Ely R. Callaway, Jr.; Professor of Chemistry; Director, Worm Institute for Research & Medicine (WIRM)
The Scripps Research Institute

Bacteria, Cancer, Addiction: Searching for Molecules that have Physiological Relevance

Faculty Host: Amanda Garner ( algarner@umich.edu ) 763-2654 Student Host: Erin Gallagher ( eribeth@umich.edu )
Speaker Website
October 2, 2014
4:00pm
Palmer Commons, Forum Hall
John G. Topliss Lecture-William L. Jorgensen, PhD
Sterling Professor of Chemistry;Director, Division of Physical Sciences & Engineering
Yale University

Efficient Lead Optimization Guided by Free-Energy Calculations

Faculty Host: Heather Carlson ( carlsonh@umich.edu ) 615-6841
Speaker Website Speaker Abstract
November 13, 2014
4:00pm
2548 CC Little
Peter Wipf, PhD
Distinguished University Professor; Director of the Combinatorial Chemistry Center (CCC) and the Center for Chemical Methodologies and Library Development (UPCMLD)
University of Pittsburgh, Department of Chemistry

Chemical Inhibition of Protein Kinase D

Faculty Host: Scott Larsen ( sdlarsen@umich.edu ) 615-0454
Speaker Website Speaker Abstract
December 1, 2014
10:00am
Rackham Graduate School, East Conference Room
Xu Ran
Medicinal Chemistry Ph.D. Candidate
University of Michigan

Oral Dissertation Defense "Peptide and nonpeptide approaches to target Protein-protein interactions for the treatment of cancer"

Faculty Host: Shaomeng Wang ( shaomeng@umich.edu ) 615-0362
January 6, 2015
4:00pm
2548 CC Little
Michael Van Nieuwenhze, PhD
Associate Professor of Chemistry and Adjunct Professor of Microbiology, Molecular and Cellular Chemistry
Indiana University

Novel Chemical Probes for Use in the Study of Bacterial Peptidoglycan Biosynthesis

Faculty Host: Hank Mosberg ( him@umich.edu ) 764-8117
Speaker Website
January 15, 2015
4:00pm
2548 CC Little
Qing Lin, PhD
Associate Professor
Department of Chemistry, The State University of New York at Buffalo

Opportunities at the Interface of Chemistry and Biology: A Bioorthogonal Chemistry Perspective

Faculty Host: Hank Mosberg ( him@umich.edu ) 764-8117
Speaker Website
January 20, 2015
4:00pm
2548 CC Little
Helen Waldschmidt
Medicinal Chemistry, Third Year PhD Student
University of Michigan

Targeting G-protein coupled receptor kinase 2 as a potential heart therapeutic


January 21, 2015
2:30-3:30pm
2548 CC Little
Emily Scott, PhD
Associate Professor
Department of Medicinal Chemistry, University of Kansas

Structure/Function Studies of Human Steroidogenic Cytochrome P450 17A1: Improving Prostate Cancer Drug Design

Faculty Host: Hank Mosberg ( him@umich.edu ) 764-8117
Speaker Website
January 22, 2015
4:00pm
2548 CC Little
Mike Agius
Medicinal Chemistry, Third Year PhD Student
University of Michigan

Development of Conformational Selective c-Src Inhibitors: Modulating the non-catalytic functions of c-Src Kinase


January 27, 2015
4:00pm
2548 CC Little
Nate Scharf
Medicinal Chemistry, Third Year PhD Student
University of Michigan

Development of in vitro Transcription Assay for Identification of Novel M. tuberculosis RNAP Inhibitors


January 29, 2015
4:00pm
2548 CC Little
Eric Lachacz
Medicinal Chemistry, Third Year PhD Student
University of Michigan

Profiled Kinase Inhibitors for Molecularly Targeting Sarcomas


February 3, 2015
4:00pm
2548 CC Little
Megan Stewart
Medicinal Chemistry, Third Year PhD Student
University of Michigan

Strategies for Green Fluorine-18 Radiochemistry & Dopamine D3 Receptor Radiotracer Discovery


February 12, 2015
4:00pm
2548 CC Little
Joe Madak
Medicinal Chemistry, Third Year PhD Student
University of Michigan

A Phenotypic Screen for the Development of New Therapeutics for Pancreatic Cancer


February 17, 2015
4:00pm
2548 CC Little
Max Stefan
Medicinal Chemistry, Third Year PhD Student
University of Michigan

Mycobacterium tuberculosis RNA polymerase: Compensatory Evolution and Therapeutic Development


February 19, 2015
4:00pm
2548 CC Little
Isaac Krauss, PhD
Assistant Professor of Chemistry
Brandeis University

Combining Organic Synthesis and Directed Evolution to Design HIV Carbohydrate Vaccine Candidates

Faculty Host: Hank Mosberg ( him@umich.edu ) 764-8117
Speaker Website
February 23, 2015
3:00pm
2548 CC Little
Douglas A. Hansen
Medicinal Chemistry, Ph.D. Candidate
University of Michigan

PhD dissertation Defense: Type I Polyketide Synthases: Methodology, Biocatalysis, and Evaluation of Substrate Promiscuity

Faculty Host: David Sherman ( davidhs@umich.edu ) 615-9907
February 24, 2015
4:00pm
2548 CC Little
Shasha Li
Medicinal Chemistry, Third Year PhD Student
University of Michigan

Hapalindole-type Alkaloids from Cyanobacteria: Characterization of Biosynthetic Pathway for Drug Discovery


February 26, 2015
10:00am
Rackham Graduate School, East Conference Room
Kyle Heslip
Medicinal Chemistry, Ph.D. Candidate
University of Michigan

PhD dissertation Defense: Inhibiting the Actions of Essential Biomolecule Phosphopantetheine

Faculty Host: Ronald W. Woodard ( rww@umich.edu ) 764-7366
March 12, 2015
4:00pm
2548 CC Little
Craig Townsend, PhD
Alsoph H. Corwin Professor of Chemistry
Johns Hopkins University

Biosynthesis of -Lactam Antibiotics and the Force of Convergent Evolution

Faculty Host: Ron Woodard ( rww@umich.edu ) 764-7366
Speaker Website Speaker Abstract
March 17, 2015
4:00pm
2548 CC Little
Jennifer Schmidt
Medicinal Chemistry, Third Year PhD Student
University of Michigan

Formation and evaluation of novel unit A cryptophycin analogues through the use of a thioesterase biocatalyst


March 19, 2015
4:00pm
2548 CC Little
Michael Barbachyn, PhD
Brummel Professor of Chemistry
Calvin College

Challenges in the Discovery of New Antibacterial Agents

Faculty Host: Hollis Showalter ( showalh@umich.edu )
Speaker Website Speaker Abstract
March 24, 2015
4:00pm
2548 CC Little
Will Kaplan
Medicinal Chemistry, Third Year PhD Student
University of Michigan

Simple, Stereoselective, and Drug-oriented Synthesis of Steroids and their Polyoxygenated Derivatives


March 26, 2015
4:00pm
2548 CC Little
Julie Boerner, PhD
Assistant Professor, and Director of Chemical Biology Graduate Admissions
Karmanos Cancer Institute/Department of Pharmacology, Wayne State University School of Medicine

Src Family Kinases in Triple-Negative Breast Cancer

Faculty Host: Matt Soellner ( soellner@umich.edu ) 615-2767
Speaker Website
April 2, 2015
4:00pm
2548 CC Little
Alex Tropsha, PhD
K.H. Lee Distinguished Professor and Associate Dean for Research
University of North Carolina at Chapel Hill, Eshelman School of Pharmacy

On the Importance of Data Curation in Molecular Modeling

Faculty Host: Heather Carlson ( carlsonh@umich.edu ) 615-6841
Speaker Website
April 9, 2015
4:00pm
2548 CC Little
Bryan Smith, PhD
Senior Director of Biology
Deciphera Pharmaceuticals; Lawrence, Kansas

Kinase inhibitors targeting the tumor and tumor microenvironment

Faculty Host: Matt Soellner ( soellner@umich.edu ) 615-2767
Speaker Website
April 22, 2015
9:00am
2548 CC Little
Hao Xu
Medicinal Chemistry, Ph.D. Candidate
University of Michigan

PhD Dissertation Defense: Profiling Ester Prodrugs Activation: an Activity Based Protein Profiling (ABPP) Approach

Faculty Host: Gordon Amidon ( glamidon@umich.edy ) 764-2464
April 23, 2015
4:00pm
2548 CC Little
Leyte Winfield, PhD
Associate Professor of Organic Chemistry and Chair, Department of Chemistry and Biochemistry
Spelman College; Atlanta, Georgia

Treatment Outcomes of LLW-3-6 in Prostate and Brain Cancer Cells

Faculty Host: Ronald W. Woodard ( rww@umich.edu ) 764-7366
Speaker Website
May 14, 2015
11:00am
2548 CC Little
Anthony R. Porcari, PhD
Director in Clinical Sciences
Pfizer

Tenth Annual Leroy B. Townsend Symposium: Recent advances in the treatment of venous thromboembolism: the role of new oral anticoagulants (NOACs)

Faculty Host: Ronald W. Woodard 764-7366
May 20, 2015
10:00am
2548 CC Little
Phani Ghanakota
Medicinal Chemistry, Ph.D. Candidate
University of Michigan

PhD Dissertation Defense: Incorporating Hotspot Mapping and Allostery in Structure Based Drug Design

Faculty Host: Heather Carlson ( carlsonh@umich.edu ) 615-6841
June 11, 2015
4:00pm
1544 CC Little
Frederick T. Chin, Ph.D.
Assistant Professor (Research) of Radiology (General Radiology); Stanford University Member, Molecular Imaging Program at Stanford Head, Cyclotron Radiochemistry
Stanford University School of Medicine

New Strategies for PET Imaging in Oncology and Neurology

Faculty Host: Peter Scott ( pjhscott@umich.edu ) 615-1756 Student Host: Jason Miller ( jaymil@umich.edu )
Speaker Website Speaker Abstract
September 17, 2015
4:00pm
2548 CC Little
Shaomeng Wang, PhD
Professor of Internal Medicine, Pharmacology, and Medicinal Chemistry
University of Michigan

Building a successful drug discovery program in Academia

Faculty Host: Amanda Garner ( algarner@umich.edu )
Speaker Website
October 15, 2015
4:00pm
2548 CC Little
Peter J. Scott, PhD
Research Assistant Professor, Radiology
University of Michigan

New Strategies for Late-stage Fluorination and PET Imaging of Neurodegenerative Disorders

Faculty Host: Amanda Garner ( algarner@umich.edu )
Speaker Website Speaker Abstract
October 29, 2015
4:00pm
Forum Hall, Fourth Floor, Palmer Commons
Christine Humblet, PhD
Research Fellow
Lilly Research Laboratories, Indianapolis, IN

John G. Topliss Award Lecture: “Transforming drug discovery through predictive sciences. Computational Chemistry & Cheminformatics at Lilly”

Faculty Host: Hollis Showalter ( showalh@umich.edu )
November 5, 2015
4:00pm
2548 CC Little
Bill Wuest, PhD
Assistant Professor
Department of Chemistry, Temple University

Draining the Moat: A Natural Product-Inspired Approach to Combat Bacterial Biofilms

Faculty Host: David Sherman ( davidhs@umich.edu ) 615-6907
Speaker Website Speaker Abstract
November 12, 2015
4:00pm
2548 CC Little
Donna Huryn, PhD
Research Professor, University of Pittsburgh, School of Pharmacy
Adjunct Professor of Chemistry, University of Pennsylvania

New Approaches to Modulating Protein Homeostasis in Cancer: Discovery and Optimization of Allosteric Inhibitors of p97

Faculty Host: George A. Garcia ( gagarcia@umich.edu ) 764-2202 Student Host: Andrea Shergalis ( ashergal@umich.edu )
Speaker Website
November 20, 2015
10:00am
4th Floor West Conference Room, Rackham
Anthony Emanuele
Medicinal Chemistry, Ph.D. Candidate, PSTP Trainee
University of Michigan

PhD Dissertation Defense: Antibiotic Discovery Campaign Targeting VirF, the Main Transcriptional Regulator of Virulence in Shigella flexneri

Faculty Host: George Garcia ( gagarcia@umich.edu ) 764-2202
December 2, 2015
12:00pm
1706 Chemistry Building
Frank Kwarcinski
Medicinal Chemistry Ph.D. Candidate
University of Michigan

PhD Dissertation Defense: Developing Kinase Inhibitors as Chemical Tools and Potential Drugs

Faculty Host: Matt Soellner ( soellner@umich.edu ) 615-2767
December 3, 2015
4:00pm
2548 CC Little
Kathleen A. Stringer, PhD
Professor
Clinical Pharmacy Department, College of Pharmacy, University of Michigan

The Metabolomics of Drug Bioaccumulation in Macrophages: The Story of Clofazimine

Faculty Host: Amanda Garner ( algarner@umich.edu )
Speaker Website Speaker Abstract
January 7, 2016
10:00am
Rackham Graduate School, West Conference Room (Fourth Floor)
Aubrie Harland
Medicinal Chemistry, Ph.D. Candidate
University of Michigan

PhD Dissertation Defense, Design, Synthesis, and Optimization of Opioid Receptor Peptidomimetics

Faculty Host: Henry I. Mosberg ( him@umich.edu ) 764-8117
January 12, 2016
1:00pm
2548 CC Little
Aaron Bender
Medicinal Chemistry, Ph.D. Candidate
University of Michigan

Ph.D. Dissertation Defense: Synthesis and Evaluation of Mixed Efficacy Mu Opioid Receptor (MOR), Delta Opioid Receptor (DOR) Small Molecule Ligands

Faculty Host: Henry I. Mosberg ( him@umich.edu ) 764-8117
January 19, 2016
4:00pm
2548 CC Little
Erin Gallagher
Medicinal Chemistry, Ph.D. Candidate
University of Michigan

Third Year Student Seminar: Modulating the eIF4E-4E-BP Protein-Protein Interaction

Faculty Host: Amanda Garner ( algarner@umich.edu ) 763-2654
Speaker Abstract
February 4, 2016
4:00pm
2548 CC Little
Yangbing Li
Medicinal Chemistry, Ph.D. Candidate
University of Michigan

Third Year Student Seminar: Design of Selective BRM Bromodomain Inhibitors and Bivalent Small-Molecule Degraders of BRM for the Treatment of BRG1-Deficient Cancer

Faculty Host: Amanda Garner ( algarner@umich.edu ) 763-2654
Speaker Abstract
February 9, 2016
4:00pm
2548 CC Little
Brandt Huddle
Medicinal Chemistry, Ph.D. Candidate
University of Michigan

Third Year Student Seminar: Development of Ovarian Cancer Stem Cell Depleting ALDH Inhibitors

Faculty Host: Amanda Garner ( algarner@umich.edu ) 763-2654
Speaker Abstract
February 11, 2016
4:00pm
2548 CC Little
Tony Nastase
Medicinal Chemistry, Ph.D. Candidate
University of Michigan

Third Year Student Seminar: Design and Synthesis of Bifunctional Opioid Receptor Peptidomimetics

Faculty Host: Amanda Garner ( algarner@umich.edu ) 763-2654
Speaker Abstract
February 18, 2016
4:00pm
2548 CC Little
Ting-Rong Chern
Medicinal Chemistry, Ph.D. Candidate
University of Michigan

Third Year Student Seminar: Design, Synthesis and Characterization of Small Molecules Targeting MLL1 Methyltransferase in Mixed-Lineage Leukemia

Faculty Host: Amanda Garner ( algarner@umich.edu ) 763-2654
Speaker Abstract
March 8, 2016
4:00pm
2548 CC Little
Allie Sowa
Medicinal Chemistry, Ph.D. Candidate
University of Michigan

Third Year Student Seminar: Syntheses and Evaluation of GAT-1 Specific PET Probes

Faculty Host: Amanda Garner ( algarner@umich.edu ) 763-2654
Speaker Abstract
March 10, 2016
4:00pm
2548 CC Little
Jeff Zwicker
Medicinal Chemistry, Ph.D. Candidate
University of Michigan

Third Year Student Seminar: DEVELOPMENT OF SELECTIVE AND BRAIN PENETRANT INHIBITORS OF T. GONDII CATHEPSIN L

Faculty Host: Amanda Garner ( algarner@umich.edu ) 763-2654
Speaker Abstract
March 17, 2016
4:00pm
2548 CC Little
Indraneel, Ghosh, PhD
Associate Professor, Department of Chemistry and Biochemistry
University of Arizona

Split-Protein Engineering and Design: From Biosensors to Kinomics

Faculty Host: Matt Soellner ( soellner@umich.edu ) 615-2767
Speaker Website Speaker Abstract
March 24, 2016
4:00pm
2548 CC Little
Peter L. Toogood, PhD
Senior Vice President, Chemistry and Chemical Biology
Lycera Corporation Pharmaceutical Company

Restoring Immune Balance Through Modulation of Metabolism and Cytokine Networks

Faculty Host: Scott Larsen ( sdlarsen@umich.edu ) 615-0454
Speaker Website
April 8, 2016
9:00am
Palmer Commons, Forum Hall, (fourth floor)
Denton Hoyer, PhD
Director of Chemistry, Yale Center for Molecular Discovery
Yale University

Properties Matter: Pitfalls and Opportunities in Chemical Space

Faculty Host: Amanda Garner ( algarner@umich.edu ) 763-2654
Speaker Website
May 19, 2016
2:00pm; Reception preceding lecture at 1:30 pm in room 2544 CC Little Building
2548 CC Little
Leah Makley, PhD; Eleventh Annual Leroy B. Townsend Symposium
Chief Scientific Officer, Director;
Viewpoint Therapeutics, San Francisco, California

Development of a Medical Treatment for Cataract Based on a Pharmacological Chaperone of alpha-Crystallin

Faculty Host: George A. Garcia ( gagarcia@umich.edu ) 734-764-2202
Speaker Website Speaker Abstract
August 29, 2016
9:00am
Life Sciences Institute Library, Room 3040
Michael F. Rafferty, Ph.D.
Vice President of Preclinical Development
Deciphera Pharmaceuticals, LLC.

Medicinal Chemistry Education: Issues and Opportunities

Faculty Host: Vincent E. Groppi, Ph.D. ( vegroppi@umich.edu )
Speaker Abstract
September 14, 2016
10:00am
Rackham Building, East Conference Room-Fourth Floor
Ahmed S. A. Mady
Medcinal Chemistry, PhD Candidate
University of Michigan

Dissertation Defense: Development and characterization of novel Mcl-1 inhibitors for treatment of cancer

Faculty Host: Zaneta Nikolvska-Coleska ( zanetan@umich.edu ) 615-9202
Speaker Abstract
September 15, 2016
4:00pm
2548 CC Little
Julio Camarero, PhD
Associate Professor, Programs in Biomedical and Biological Sciences
University of Southern California (USC)

Cyclotides, a New Molecular Scaffold to Target Protein-Protein Interactions

Faculty Host: Nouri Neamati ( neamati@umich.edu ) 647-2732
Speaker Website Speaker Abstract
September 23, 2016
9:00am
Rackham Amphitheater and Assembly Hall (Fourth Floor)
Amanda Garner, PhD
Assistant Professor of Medicinal Chemistry
University of Michigan

Inaugural ACS MedChemSymposium: Chemical Approaches for Targeting Translational Control

Student Host: Lindsey Drake ( lrdrake@umich.edu )
Speaker Website
September 23, 2016
10:30am
Rackham Amphitheater and Assembly Hall (Fourth Floor)
Emily Scott, PhD
Associate Professor of Medicinal Chemistry and Associate Professor of Pharmacology
University of Michigan

Inaugural ACS MedChem Symposium: Cytochrome P450 17A1: Prostate Cancer Drug Target

Student Host: Lindsey Drake ( lrdrake@umich.edu )
Speaker Website
September 30, 2016
2:00pm
2548 CC Little
Zapporah Young
Medicinal Chemistry, Ph.D. Candidate
University of Michigan

Dissertation Defense: Chemical Modulators of Heat Shock Protein 70 (Hsp70) Validate this Molecular Chaperone as a Target for Tauopathy

Faculty Host: Scott Larsen ( sdlarsen@umich.edu ) 615-0454
October 20, 2016
4:00pm
2548 CC Little
Markos Koutmos
Assistant Professor of Biochemistry and Molecular Biology
Uniformed Services University of the Health Sciences

RNA processing by mitochondrial RNase Ps; a new class of ribonucleases and their role in mitochondrial function


Speaker Website
October 21, 2016
10:00 am
North Campus Research Complex (NCRC) Building 10, Research Auditorium
Parag Aggarwal, Ph.D. (UM-Medicinal Chemistry Alumni)
Senior Program Officer, Addressing Disparities team
Patient-Centered Outcomes Research Institute (PCORI)

Research Funding at the Patient-Centered Outcomes Research Institute: Addressing Disparities Program

Faculty Host: Stacey Trosell ( strosell@umich.edu )
Speaker Website
October 27, 2016
4:00pm
2548 CC Little
Michelle Arkin, PhD
Associate Professor, Department of Pharmaceutical Chemistry
University of California, San Francisco (UCSF)

Drug Discovery Challenges, Large and Small

Faculty Host: Amanda Garner ( algarner@umich.edu ) 763-2654
Speaker Website
November 17, 2016
4:00pm
Palmer Commons Forum Hall
Ruth Wexler, PhD
Executive Director, Discovery Chemistry
Bristol-Myers Squibb

John G. Topliss Award Lecture- Adventures in Cardiovascular Drug Discovery: New Frontiers and Lessons Learned

Faculty Host: Scott Larsen ( sdlarsen@umich.edu ) 734-615-0454
Speaker Website Speaker Abstract
November 24, 2016
n/a
n/a
No Seminar-Thanksgiving Holiday

N/A


December 2, 2016
11:00am
1040 Dana Natural Resources Building
Taylor Johnson
Medicinal Chemistry, Ph.D. Candidate
University of Michigan

Combining Active Site and Allosteric Inhibitors to Study Protein Tyrosine Kinases

Faculty Host: Matt Soellner ( soellner@umich.edu ) 615-2767
December 15, 2016
1:00pm
Rackham Graduate School, West Conference Room (Fourth Floor)
Andrew C. Pratt
Medicinal Chemistry PhD Candidate
University of Michigan

Oral Dissertation Defense: Functional analysis of early core region modification in the lipopolysaccharide of Gram-negative bacteria

Faculty Host: Ronald Woodard ( rww@umich.edu ) 764-7366
January 12, 2017
4:00pm
2548 CC Little
Tim Cernak, PhD
Associate Principal Scientist
Merck and Co., Boston, MA

Enabling Technologies in the Quest for New Medicines

Faculty Host: Nouri Neamati ( neamati@umich.edu )
January 17, 2017
4:00pm
2548 CC Little
Nathalie Busschaert, PhD
Post-Doctoral Researcher
New York University

Supramolecular solutions to biomedical problems: From transmembrane anion transporters to protein-protein interaction inhibitors

Faculty Host: Nouri Neamati ( neamati@umich.edu )
January 17, 2017
4:00pm
2548 CC Little
Dennis Buckley, PhD
Damon Runyan Postdoctoral Fellow
Dana Farber Cancer Institute, Harvard Medical School

Design of small molecule inducers of protein degradation, and their use as chemical probes

Faculty Host: Nouri Neamati ( neamati@umich.edu )
January 24, 2017
4:00pm
2548 CC Little
Megan Matthews, PhD
Helen Hay Whitney Postdoctoral Fellow
Department of Chemical Physiology, Scripps Research Institute

Chemoproteomic profiling and discovery of protein electrophiles in human cells

Faculty Host: Nouri Neamati ( neamati@umich.edu )
January 31, 2017
4:00pm
2548 CC Little
Hubert Yin, PhD
Associate Professor of Chemistry and Biochemistry
University of Colorado at Boulder

Drugging the Undruggable: Targeting Membrane Protein Interactions

Faculty Host: Nouri Neamati ( neamati@umich.edu )
February 7, 2017
4:00pm
2548 CC Little
Sumit Bandekar
MedChem PhD Candidate, Third Year Student Seminar
University of Michigan

Structure, Function, and Inhibition of the Oncogenic RhoGEF TrioC


Speaker Abstract
February 14, 2017
4:00pm
2548 CC Little
Lindsey Drake
MedChem PhD Candidate, Third Year Student Seminar
University of Michigan

Development of PET Probes for Biomarkers of Neuroinflammation


Speaker Abstract
February 16, 2017
4:00pm
2548 CC Little
Amy Fraley
MedChem PhD Candidate, Third Year Student Seminar
University of Michigan

MalA: an iterative halogenase for late-stage C-H functionalization of indole alkaloids


Speaker Abstract
February 21, 2017
4:00pm
2548 CC Little
Ashootosh Tripathi, PhD
Research Investigator
Life Sciences Institute, University of Michigan

Microbes to Medicine: Development of a Millennial Drug Discovery Platform

Faculty Host: David Sherman ( davidhs@umich.edu ) 615-9907
Speaker Abstract
February 23, 2017
4:00pm
2548 CC Little
Shuai Hu
MedChem PhD Candidate, Third Year Student Seminar
University of Michigan

Discovery of Novel Small-Molecule Reactive Oxygen Species (ROS) Inducers for Treating Pancreatic Cancer


Speaker Abstract
March 7, 2017
4:00pm
2548 CC Little
Christine Cuthbertson
MedChem PhD Candidate, Third Year Student Seminar
University of Michigan

Discovery of First-in-Class SHMT2 and MTHFD2 Inhibitors for Non-Small Cell Lung Cancer


Speaker Abstract
March 9, 2017
4:00pm
2548 CC Little
Jeonghyo Lee
MedChem PhD Candidate, Third Year Student Seminar
University of Michigan

Chiral phosphoric acids catalyzed regioselective and desymmetrizative glycosylation leading to the synthesis of aminoglycoside derivatives


Speaker Abstract
March 14, 2017
4:00pm
2548 CC Little
Nick Ragazzone
MedChem PhD Candidate, Third Year Student Seminar
University of Michigan

Development of Novel Inhibitors Targeting VirF, the Key Virulence Regulator of Shigella flexneri


Speaker Abstract
March 16, 2017
4:00pm
2548 CC Little
Vikram Shenoy
MedChem PhD Candidate, Third Year Student Seminar
University of Michigan

A novel fluorophosphonate probe for the identification of new valacyclovir-activating enzymes


Speaker Abstract
March 21, 2017
4:00pm
2548 CC Little
Andrea Shergalis
MedChem Ph.D.Candidate, Third Year Student Seminar
University of Michigan

Preclinical evaluation of protein disulfide isomerase inhibitors for the treatment of glioblastoma


Speaker Abstract
March 23, 2017
4:00pm
2548 CC Little
Dylan Kahl
MedChem PhD Candidate, Third Year Student Seminar
University of Michigan

Target Identification Studies for Two Novel Series of Rho-mediated Gene Transcription Inhibitors


March 28, 2017
4:00pm
2548 CC Little
Sean Henry
MedChem PhD Candidate, Third Year Student Seminar
University of Michigan

Development of Bifunctional Peptidomimetic Ligands as Novel Opioid Analgesics


Speaker Abstract
April 6, 2017
4:00pm
2548 CC Little
John K. Buolamwini, PhD
Professor and Chair, Pharmaceutical Sciences Department, College of Pharmacy
Rosalind Franklin University of Medicine and Science

Design and Discovery of Potential Therapeutic Leads Targeted to Cancer, Heart and Viral Diseases


May 1, 2017
10:00am
Earl Lewis Room, Third Floor, Rackham Graduate School
David Cech
PhD Candidate, Dissertation Defense Seminar
University of Michigan, Department of Medicinal Chemistry

Insights into the Mechanistic and Regulatory Properties of D-arabinose-5-phosphate Isomerases

Faculty Host: Ronald Woodard ( rww@umich.edu )
May 3, 2017
10:00am
1706 Chemistry Building
Will P. Kaplan
PhD Candidate, Dissertation Defense Seminar
University of Michigan, Department of Medicinal Chemistry

Drug-Oriented Synthesis of Cardiotonic Steroids

Faculty Host: Pavel Nagorny ( nagorny@umich.edu )
May 18, 2017
2:00pm
2548 CC Little
Leroy B. Townsend Lectureship; Ji-Wang Chern, PhD, University of Michigan Alumnus, Medicinal Chemistry PhD, 1985
Distinguished Professor, School of Pharmacy; and Director, Center for Innovative Therapeutics Discovery,
National Taiwan University

Development of HDAC6 inhibitor as anticancer agent via autophagy inhibition and PD-L1 blockade

Faculty Host: George A. Garcia ( gagarcia@umich.edu )
May 25, 2017
2:00pm
2548 CC Little
Helen Waldschmidt
PhD Candidate, Dissertation Defense Seminar
University of Michigan, Department of Medicinal Chemistry

Development, synthesis, and characterization of G protein-coupled receptor kinase inhibitors using structure based drug design for the advancement of heart failure therapeutics

Faculty Host: Scott Larsen ( sdlarsen@umich.edu )
August 3, 2017
10:00am
2548 CC Little
Nathan Scharf
PhD Candidate, Disseration Defense Seminar
University of Michigan, Department of Medicinal Chemistry

Identification and Evaluation of Bacterial RNA Polymerase Inhibitors Using a Novel Plasmid-based Transcription Assay

Faculty Host: George A. Garcia ( gagarcia@umich.edu )
August 17, 2017
10:00am
2548 CC Little Building
Michael Agius
PhD Candidate, Dissertation Defense Seminar
University of Michigan, Department of Medicinal Chemistry

Modulating the Global Conformations of c-Src Kinase

Faculty Host: Matt Soellner ( soellner@umich.edu )
August 24, 2017
10:00am
2548 CC Little
Eric Lachacz
PhD Candidate, Dissertation Defense Seminar
University of Michigan, Department of Medicinal Chemistry

Developing Target Identification Platforms Using Profiled Kinase Inhibitors

Faculty Host: Matt Soellner ( soellner@umich.edu )
September 21, 2017
4:00pm
Forum Hall, Palmer Commons
Arun K. Ghosh, Ph.D.
Ian P. Rothwell Distinguished Professor and Organic Division Chair
Department of Chemistry & Department of Medicinal Chemistry, Purdue University

John G. Topliss Award Lecture: Molecular Design Strategies to Combat HIV/AIDS Drug-resistance

Faculty Host: Andy White ( whitandd@umich.edu ) 647-7374
Speaker Website
October 5, 2017
4:00pm
2548 CC Little
Deanna Montgomery
MedChem Ph.D. Candidate
University of Michigan

Student Seminar: Design and Synthesis of Opioid Peptidomimetics for Treatment of Addiction

Faculty Host: Hank Mosberg
Speaker Abstract
October 12, 2017
4:00pm
2548 CC Little
Jonathan Z. Sexton, PhD
Associate Professor, Pharmaceutical Sciences; Director of Drug Discovery, BRITE
North Carolina Central University

Discovery and Development of Novel Activators of AMP-Activated Protein Kinase as Potential Therapeutics for Fatty Liver Disease and NASH


Speaker Website Speaker Abstract
November 2, 2017
4:00pm
2548 CC Little
Jason K. Sello, PhD
Associate Professor of Chemistry
Department of Chemistry, Brown University; Providence, Rhode Island

Novel Small Molecules, Targets, and Strategies in Anti-Infective Development

Faculty Host: George Garcia ( gagarcia@umich.edu ) 764-2022 Student Host: Nick Ragazzone ( nragazzo@umich.edu )
Speaker Website
November 6, 2017
10:00am
Rackham Graduate School, Earl Lewis Room, Third Floor
Shasha Li
PhD Candidate, Dissertation Defense Seminar
Department of Medicinal Chemistry, University of Michigan

Decoding the Bio-assembly of Hapalindole-type Alkaloids from Cyanobacteria for Drug Discovery

Faculty Host: David Sherman ( davidhs@umich.edu ) 615-9907
November 16, 2017
4:00pm
2548 CC Little
Roger D. Cone, PhD
Vice Provost and Director of the Biosciences Initiative; Asa Gray Collegiate Professor of the Life Sciences, Mary Sue Coleman Director of the Life Sciences Institute;
Professor of Molecular, Cellular and Developmental Biology, and Professor of Molecular and Integrative Physiology, University of Michigan

Allosteric Modulators of the Melanocortin-4 Receptor

Faculty Host: Emily Scott ( scottee@umich.edu ) 764-3530 Student Host: Sarah Burris
Speaker Website
November 30, 2017
4:00pm
2548 CC Little
John Montgomery, PhD
Margaret and Herman Sokol Professor in Medicinal or Synthetic Chemistry
Department of Chemistry, University of Michigan

Development of New Catalytic Reactions for Late-Stage Diversification

Faculty Host: David Sherman ( davidhs@umich.edu ) 615-9907
Speaker Website
December 7, 2017
4:00pm
2548 CC Little
Yoichi Osawa, Ph.D.
Warner-Lambert/Parke-Davis Professor in Medicine
Department of Pharmacology, University of Michigan

Surveillance of Protein Clefts by Chaperones in Protein Quality Control: Rationale for a New Approach in Treatment of Protein Folding Diseases

Faculty Host: Emily Scott ( scottee@umich.edu ) 764-3530
Speaker Website
December 7, 2017
1:00pm
Location To Be Announced
Megan Stewart
PhD Candidate, Dissertation Defense Seminar
Department of Medicinal Chemistry, University of Michigan

Positron Emission Tomography Radiochemistry: Improved Methodology and a Novel PET Imaging Agent for the Dopamine D3 Receptor

Faculty Host: Peter J. Scott ( pjhscott@umich.edu ) 615-1756
January 17, 2018
1:00pm
NCRC Building 10, Research Auditorium
Joseph Madak
PhD Candidate, Dissertation Defense Seminar
Department of Medicinal Chemistry, University of Michigan

Design and Synthesis of Novel Dihydroorotate Dehydrogenase Inhibitors

Faculty Host: Nouri Neamati ( neamati@umich.edu ) 647-2732
January 18, 2018
4:00pm
2548 CC Little
Melanie D. Ohi, PhD
Associate Professor; Research Associate Professor, Life Sciences Institute
Medical School, Cell and Developmental Biology; University of Michigan

Structural analysis of dynamic molecular machines using cryo-electron microscopy

Faculty Host: Amanda Garner
Speaker Website
January 23, 2018
4:00pm
2548 CC Little
Maria Fawaz
PhD Candidate, MedChem Student Seminar
Department of Medicinal Chemistry, University of Michigan

MedChem Student Seminar: Synthetic HDL Lipid Scavengers for the Treatment of Niemann-Pick Diseases

Faculty Host: Anna Schwendeman ( annaschw@umich.edu )
Speaker Abstract
January 25, 2018
4:00pm
2548 CC Little
Andrei Lomize, PhD
Research Scientist
Department of Medicinal Chemistry, University of Michigan

Developments of computational tools and databases to study proteins and drugs in membranes

Faculty Host: Henry I. Mosberg ( him@umich.edu )
Speaker Website
February 6, 2018
4:00pm
2548 CC Little
Shireen Ashkar
PhD Candidate, MedChem Student Seminar
Department of Medicinal Chemistry, University of Michigan

Development of Novel Inhibitors for Rifamycin-resistant RNA Polymerase of Mycobacterium tuberculosis

Faculty Host: George A. Garcia ( gagarcia@umich.edu )
Speaker Abstract
February 8, 2018
4:00pm
2548 CC Little
Brandon Ruotolo
Associate Professor
Department of Chemistry, University of Michigan

Gas-phase Structural Biology: New Technologies for Rapidly Assessing Protein Complex Sequence, Structure and Stability

Faculty Host: David Sherman ( davidhs@umich.edu ) 615-9907
Speaker Website Speaker Abstract
February 13, 2018
4:00pm
2548 CC Little
Katherine Guild
PhD Candidate, MedChem Student Seminar
Department of Medicinal Chemistry, University of Michigan

Investigation of Mycobacterium tuberculosis RNA Polymerase for the Development of Novel Drug Candidates

Faculty Host: George A. Garcia ( gagarcia@umich.edu )
Speaker Abstract
February 22, 2018
4:00pm
2548 CC Little
Rachel Rowlands
PhD Candidate, MedChem Student Seminar
Department of Medicinal Chemistry, University of Michigan

Development of Selective, Covalent Inhibitors of GRK5 for Treatment of Heart Failure

Faculty Host: Andy White ( whitandd@umich.edu )
Speaker Abstract
March 8, 2018
4:00pm
2548 CC Little
Yongcheng Song, PhD
Associate Professor, Pharmacology and Chemical Biology
Baylor University, Baylor College of Medicine; Houston, TX

Small Molecule Probes Targeting Histone Methylation for Cancer Therapy

Faculty Host: Shaomeng Wang ( shaomeng@umich.edu ) 615-0362
Speaker Website
March 22, 2018
4:00pm
2548 CC Little
Bob Kennedy, PhD
Interim President and CEO
Vestaron Corporation; Kalamazoo, MI

Venom Peptides in Drug Design and as Novel Insecticides

Faculty Host: Scott D. Larsen ( sdlarsen@umich.edu ) 615-0454
Speaker Website Speaker Abstract
April 5, 2018
4:00pm
2548 CC Little
Matt Bogyo, PhD
Professor of Pathology and of Microbiology and Immunology
Stanford University

Chemical probes for imaging and therapeutic applications in cancer and infectious disease

Faculty Host: Amanda Garner ( algarner@umich.edu ) 763-654
Speaker Website
April 12, 2018
4:00pm
2548 CC Little
Terry Moore, PhD
Medicinal Chemistry and Pharmacognosy
College of Pharmacy, University of Illinois

Development of Chemical Probes for Transcription Factor Interactions

Faculty Host: Amanda Garner ( algarner@umich.edu ) 763-2654
Speaker Website
May 17, 2018
2:00pm
1544 NUB
Leroy B. Townsend Award Lectureship; Yousong Ding, PhD, University of Michigan Alumnus, Medicinal Chemistry PhD, 2010
Assistant Professor of Medicinal Chemistry
University of Florida, Gainesville, FL

Exploiting Microbial Genomes to Access New Enzymology and Valuable Chemicals

Faculty Host: George A. Garcia ( gagarcia@umich.edu ) 764-2202
Speaker Website Speaker Abstract
May 17, 2018
2:00pm
1544 NUB
Leroy B. Townsend Award Lectureship; Yousong Ding, PhD, University of Michigan Alumnus, Medicinal Chemistry PhD, 2010
Assistant Professor of Medicinal Chemistry
University of Florida; Gainesville, FL

Exploiting Microbial Genomes to Access New Enzymology and Valuable Chemicals

Faculty Host: George Garcia ( gagarcia@umich.edu ) 764-2202
Speaker Website Speaker Abstract
May 18, 2018
8:30am
Rackham Amphitheater and Assembly Hall, Fourth Floor
ACS MedChem Student Chapter Career Forum with Keynote Speaker: Bruce Roth, PhD
Former Senior Vice President of Small Molecule Drug Discovery, and Co-Leader of Genentech Research
Genentech, Inc.

The Discovery and Development of Lipitor: Would Anyone Make This Molecule Today?

Faculty Host: ACS MedChem Student Chapter ( acsmediexec@umich.edu ) Student Host: Nicholas Ragazzone and Andrea Shergalis
Speaker Website Speaker Abstract
May 31, 2018
1:00pm
2548 NUB
Maxwell A. Stefan
PhD Candidate, Dissertation Defense Seminar
Department of Medicinal Chemistry, University of Michigan

Kinetic Characterization of Rifamycin-Resistant M. tuberculosis RNA polymerases and Novel Therapeutic Approach for Targeting Transcription

Faculty Host: Geogre A. Garcia ( gagarcia@umich.edu )
Speaker Abstract
June 8, 2018
9:30am
2548 NUB
Yangbing Li
PhD Candidate, Dissertation Defense Seminar
Department of Medicinal Chemistry, University of Michigan

Development of novel PROTAC Small-Molecule Degraders of MDM2 Protein and Peptidomimetic Inhibitors Targeting WDR5-MLL1 Protein-Protein Interaction

Faculty Host: Shaomeng Wang ( shaomeng@umich.edu ) 615-0362
Speaker Abstract
July 27, 2018
1:00pm
1544 NUB
Jordan Clark
PhD Candidate, Dissertation Defense Seminar
Department of Medicinal Chemistry, University of Michigan

Structural Investigation of Binding Events in Proteins

Faculty Host: Heather Carlson ( carlsonh@umich.edu ) 615-6841
August 16, 2018
2:00pm
1544 NUB
Brandt C. Huddle
PhD Candidate, Dissertation Defense Seminar
University of Michigan, Department of Medicinal Chemistry

Development of Cancer-Stem-Cell Targeting Pan-Aldehyde Dehydrogenase Inhibitors as an Adjunct to Chemotherapy in the Treatment of Ovarian Cancer

Faculty Host: Scott Larsen ( sdlarsen@umich.edu ) 615-0454
August 20, 2018
10:00am
2548 NUB
Jeffery Zwicker
PhD Candidate, Dissertation Defense Seminar
Department of Medicinal Chemistry, University of Michigan

Development of CNS Penetrant Inhibitors of Toxoplasma gondii Cathepsin L

Faculty Host: Scott Larsen
August 28, 2018
1:00pm
Palmer Commons, Forum Hall
Jennifer J. Schmidt
PhD Candidate, Dissertation Defense Seminar
Department of Medicinal Chemistry, University of Michigan

Chemoenzymatic Assembly of Macrolactones: Merging Synthetic Chemistry with Biocatalysis to Afford Diverse Compound Libraries

Faculty Host: David Sherman ( davidhs@umich.edu ) 615-9907
August 29, 2018
2:00pm
Rackham Graduate School, Earl Lewis Room
Alexandra Sowa
PhD Candidate, Dissertation Defense Seminar
University of Michigan, Department of Medicinal Chemistry

Synthesis and Evaluation of GAT-1 Selective Probes for Positron Emission Tomography

Faculty Host: Peter J H Scott ( pjhscott@med.umich.edu ) 615-1756
September 13, 2018
4:00pm
2548 NUB
James C. Barrow, Ph.D.
Associate Director, Drug Discovery and Associate Professor
Lieber Institute for Brain Development and Johns Hopkins School of Medicine

Discovery and evaluation of non-nitrocatechol COMT inhibitors for treatment of psychiatric conditions

Faculty Host: Shaomeng Wang ( shaomeng@umich.edu ) 615-0362
Speaker Website Speaker Abstract
September 20, 2018
4:00pm
2548 NUB
Amanda L. Garner, Ph.D.
Assistant Professor, Department of Medicinal Chemistry
University of Michigan

Chemical Probing of Translational Control and microRNA Biology

Faculty Host: George Garcia
Speaker Website
September 27, 2018
4:00pm
2548 NUB
Jason Kwan, PhD
Assistant Professor, Pharmaceutical Sciences Division
School of Pharmacy, University of Wisconsin, Madison

Exploring the biosynthetic potential of uncultured microbes

Faculty Host: David Sherman ( davidhs@umich.edu ) 615-9907
Speaker Website Speaker Abstract
October 4, 2018
4:00pm
Forum Hall, Palmer Commons
John G. Topliss Award Lecture, Ann E. Weber, Ph.D.
Senior Vice President - Drug Discovery
Kallyope Inc., New York, NY

From JANUVIA to MARIZEV (Omarigliptin), a Once Weekly DPP-4 Inhibitor for the Treatment of Diabetes

Faculty Host: Scott Larsen ( sdlarsen@umich.edu ) 615-0454
Speaker Abstract
October 5, 2018
2:30pm
Palmer Commons, Forum Hall
Anthony Nastase
PhD Candidate, Dissertation Defense Seminar
Department of Medicinal Chemistry, University of Michigan

The Design, Synthesis, and Pharmacological Evaluation of Bifunctional Mu-/Delta-Selective Opioid Receptor Ligands for the Treatment of Pain

Faculty Host: Henry Mosberg ( him@umich.edu ) 764.8117
October 11, 2018
4:00pm
2548 NUB
John A. Porco, Jr., Ph.D.
CMD Director and Professor of Chemistry
Department of Chemistry and Center for Molecular Discovery (BU-CMD),Boston University

Recent Studies Towards the Synthesis of Bioactive Natural Products

Faculty Host: Tim Cernak ( tcernak@umich.edu ) 647-6793
Speaker Website
October 25, 2018
4:00pm
2548 NUB
Stephen Husbands, Ph.D.
Professor, Department of Pharmacy and Pharmacology; Centre for Therapeutic Innovation
University of Bath, United Kingdom

Solving the Opioid Crisis - with Opioids

Faculty Host: John R. Traynor and Hank Mosberg ( jtraynor@umich.edu ) 647-7479
Speaker Website
November 1, 2018
4:00pm
2548 NUB
Jason M. Crawford, Ph.D.
Maxine F. Singer '57 Ph.D. Associate Professor of Chemistry and Associate Professor of Microbial Pathogenesis
Yale University; New Haven, CT

Chemistry at the Host-Bacteria Interface

Faculty Host: David Sherman ( davidhs@umich.edu ) 615-9907
Speaker Website
November 8, 2018
4:00pm
2548 NUB
Eugene Chen, PhD
Frederick G L Huetwell Professor of Cardiovascular Medicine, Professor of Internal Medicine, Professor of Surgery, Professor of Pharmacology, and Professor of Molecular and Integrative Physiology
Medical School, University of Michigan

Nitration of unsaturated fatty acids: from bench to bedside

Faculty Host: George Garcia ( gagarcia@umich.edu ) 764-2202
Speaker Website
November 13, 2018
10:30am
Fourth Floor, Palmer Commons
Third Annual ACS Medicinal Chemistry Symposium
Tom Poulos, Ph. D., University of California, Irvine; and Ann E. Weber, Kallyope Inc. New York, NY
Full Day Symposium

Full schedule to be announced

Faculty Host: ACS MEDI Graduate Student Chapter
Speaker Website Speaker Abstract
December 12, 2018
10:00am
1544 NUB
Dylan Kahl
PhD Candidate, Dissertation Defense Seminar
Department of Medicinal Chemistry, University of Michigan

Advancement of Two Novel Series of Rho-mediated Gene Transcription Inhibitors with Anti-Fibrotic Properties

Faculty Host: Scott Larsen ( sdlarsen@umich.edu ) 615-0454
December 13, 2018
2:00pm
1544 NUB
Erin Gallagher
PhD Candidate, Dissertation Defense Seminar
Department of Medicinal Chemistry, University of Michigan

Modulating the eIF4E-eIF4G Protein-Protein Interaction

Faculty Host: Amanda L. Garner ( algarner@umich.edu ) 763-2654
January 8, 2019
2:00pm
Forum Hall, Palmer Commons, Fourth Floor
Roland Kersten, PhD
Post-Doctoral Associate, Whitehead Institute for Biomedical Research
Massachusetts Institute of Technology (MIT), Cambridge, MA

Genomics-guided discovery of peptide natural products in microbes and plants

Faculty Host: TIm Cernak ( tcernak@umich.edu ) 647-6793
Speaker Website Speaker Abstract
January 24, 2019
4:00pm
2548 NUB
Sean Tanzey
PhD Candidate, MedChem Student Seminar
Department of Medicinal Chemistry, University of Michigan

Third Year Student Seminar: Synthesis and Evaluation of Metal-Specific Chelating Radioligands

Faculty Host: Peter Scott ( pjhscott@umich.edu ) 615-1756
Speaker Abstract
February 7, 2019
4:00pm
2548 NUB
Maha Zidan, M.Sc.
PhD Candidate, MedChem Student Seminar
Department of Medicinal Chemistry, University of Michigan

Third Year Student Seminar: Targeting STAT3 Signaling as a Therapeutic Approach for Cancer Treatment

Faculty Host: Nouri Neamati ( neamati@umich.edu )
Speaker Abstract
February 21, 2019
4:00pm
2548 NUB
Atsunori Kaneshige
PhD Candidate, MedChem Student Seminar
Department of Medicinal Chemistry, University of Michigan

Third Year Student Seminar: Development of Small-Molecule STAT6 Degraders

Faculty Host: Shaomeng Wang ( shaomeng@umich.edu ) 615-0362
Speaker Abstract
March 5, 2019
10:00am
Rackham West Conference Room, 4th Floor
Lindsey R. Drake
PhD Candidate, Dissertation Defense Seminar
Department of Medicinal Chemistry, University of Michigan

PET Imaging of Novel Biomarkers of Neuroinflammation

Faculty Host: Peter JH Scott ( pjhscott@umich.edu ) 615-1756
Speaker Abstract
March 14, 2019
4:00pm
2548 NUB
Tomi K. Sawyer, PhD
Distinguished Scientist, Discovery Chemistry Modalities & Peptide Drug Hunter
Merck Research Laboratories, Boston, MA

Macrocyclic Peptide Antagonists of MDM2 and MDMX: Drug Design and Cell Permeability

Faculty Host: Henry I. Mosberg ( him@umich.edu ) 764-8117
Speaker Website
March 21, 2019
4:00pm
2548 NUB
Alison Narayan, PhD
William R. Roush Assistant Professor, Research Assistant Professor, and Assistant Professor
Department of Chemistry, and Life Sciences Institute; University of Michigan

Biocatalysis and complex molecule synthesis

Faculty Host: Heather Carlson ( carlsonh@umich.edu ) 615-6841
Speaker Website
March 25, 2019
4:00pm
1544 NUB
Jeonghyo Lee
PhD Candidate, Dissertation Defense Seminar
Department of Medicinal Chemistry, University of Michigan

Chiral phosphoric acid catalyzed regioselective functionalization of carbohydrates

Faculty Host: Pavel Nagorny ( nagorny@umich.edu ) 615-2833
April 4, 2019
4:00pm
2548 NUB
Michelle James, PhD
Assistant Professor of Radiology and Neurology & Neurological Sciences
Molecular Imaging Program at Stanford (MIPS) University, School of Medicine

Developing Novel PET Tracers for Imaging Neuroimmune Interactions in CNS diseases


Speaker Website
April 11, 2019
4:00pm
2548 NUB
Bradley S. Moore, PhD
Professor, Skaggs School of Pharmacy and Pharmaceutical Sciences, and Scripps Institution of Oceanography
University of San Diego

Connecting genes to chemistry to empower small molecule discovery

Faculty Host: David H. Sherman ( davidhs@umich.edu ) 615-9907
Speaker Website
May 9, 2019
2:00pm
1544 NUB
Leroy B. Townsend Award Lectureship; Timothy C. Meredith, PhD
University of Michigan Alumnus, Medicinal Chemistry PhD, 2006
Assistant Professor of Biochemistry and Molecular Biology, Penn State University

Strategies for antimicrobial discovery....and why we need to keep looking

Faculty Host: George A. Garcia ( gagarcia@umich.edu ) 734-764-2202
Speaker Website
May 16, 2019
10:00am
1200 Chemistry Building
Reinventing Drug Discovery through Chemical Biology

Multiple Speakers

Faculty Host: Amanda Garner
Speaker Website
May 31, 2019
10:00am
Forum Hall, Palmer Commons
Amy E. Fraley
PhD Candidate, Dissertation Defense Seminar
Department of Medicinal Chemistry, University of Michigan

Molecular Basis for Selective Late-Stage Transformations in Fungal Indole Alkaloid Biosynthesis

Faculty Host: David Sherman ( davidhs@umich.edu ) 615-9907
July 19, 2019
2:00pm
Rackham Graduate School: East Conference Room, fourth floor
Deanna Montgomery
PhD Candidate, Dissertation Defense Seminar
Department of Medicinal Chemistry, University of Michigan

Design, Synthesis, and Evaluation of Novel, Multifunctional Dimethyltyrosine-Tetrahydroisoquinoline Opioid Peptidomimetics

Faculty Host: Henry I. Mosberg ( him@umich.edu ) 764-8117
September 9, 2019
3:00pm
1567 NUB
Ting-Rong Chern
PhD Candidate, Oral Dissertation Defense Seminar
Department of Medicinal Chemistry, University of Michigan

Design and Synthesis of Potent Small-Molecule Inhibitors of MLL-1 Methyltransferase and Selective Inhibitors of the DCN Protein Families

Faculty Host: Shaomeng Wang ( shaomeng@umich.edu ) 615-0362
September 26, 2019
4:00pm
2548 NUB
Edward Yu, PhD
Professor, Department of Pharmacology
Medical School, Case Western Reserve University

Fighting Superbugs

Faculty Host: Emily Scott ( scottee@umich.edu ) 764-3530 Student Host: Sarah Burris ( burriss@umich.edu )
Speaker Website Speaker Abstract
October 1, 2019
2:00pm
Palmer Commons, Forum Hall (Fourth Floor)
Sean Henry
PhD Candidate, Oral Dissertation Defense Seminar
Department of Medicinal Chemistry, University of Michigan

Structural Evolution of a Bifunctional Mu-Opioid Receptor (MOR)/Delta-Opioid Receptor (DOR) Peptidomimetic

Faculty Host: Henry I. Mosberg ( him@umich.edu ) 764-8117
October 3, 2019
4:00pm
2548 NUB
Patrick O'Brien, PhD
Associate Professor, Biological Chemistry
University of Michigan

Chemistry & Biology of Human DNA Ligases

Faculty Host: Amanda L. Garner ( algarner@umich.edu ) 763-2654
Speaker Website
October 24, 2019
4:00pm
2548 NUB
Angelo Aguilar, PhD
Assistant Research Scientist
Internal Medicine, Hematology and Oncology, University of Michigan

Discovery of APG-115 an MDM2 Inhibitor in Clinical Trials and AA-265 a PROTAC MDM2 Degrader Clinical Candidate

Faculty Host: Amanda Garner ( algarner@umich.edu ) 763-2654
October 29, 2019
2:30pm
2548 NUB
John Katzenellenbogen, PhD
Professor, Department of Chemistry
University of Illinois at Urbana-Champaign

Understanding—and Overcoming—Therapy Resistance in Breast and Prostate Cancerss

Faculty Host: Peter Scott ( pjhscott@umich.edu ) 615-1756
Speaker Website
October 31, 2019
4:00pm
2548 NUB
Laura M. Sanchez, PhD
Assistant Professor
Pharmaceutical Sciences, University of Illinois at Chicago

Visualizing Microbial and Cellular Chemistry in Situ

Faculty Host: Amanda Garner ( algarner@umich.edu ) 763-2654
Speaker Website
November 7, 2019
4:00pm
2548 NUB
Ryoma Ohi, PhD
Associate Professor of Cell & Developmental Biology, and Adjunct Research Associate Professor, Life Sciences Institute
University of Michigan

Trimming the C-Terminal Tail of Alpha-tubulin: What is it good for?

Faculty Host: Amanda Garner ( algarner@umich.edu ) 763-2654
Speaker Website
November 14, 2019
4:00pm
2548 NUB
Amanda E. Hargrove, PhD
Assistant Professor of Chemistry and Biochemistry
Duke University, Trinity College of Science and the Arts, Durham, NC

From Patterns to Function in Small Molecule: RNA Interactions

Faculty Host: Tim Cernak ( tcernak@umich.edu ) 647-6793
Speaker Website
December 6, 2019
11:00am
NCRC Building 300, Room 376
Andrea Shergalis
PhD Candidate, Oral Dissertation Defense Seminar
Department of Medicinal Chemistry, University of Michigan

Preclinical Evaluation of Protein Disulfide Isomerase Inhibitors for the Treatment of Glioblastoma

Faculty Host: Nouri Neamati ( neamati@umich.edu ) 647-2732
December 9, 2019
3:00pm
3040 Life Sciences Institute (Library)
Sumit J. Bandekar
PhD Candidate, Oral Dissertation Defense Seminar
Department of Medicinal Chemistry, University of Michigan

Structure and Function of the Oncogenic RhoGEF Trio

Faculty Host: Janet Smith ( janetsmi@umich.edu ) 615-9564
January 9, 2020
10:00am
2548 NUB
Vikram P. Shenoy
PhD Candidate, Oral Dissertation Defense Seminar
Department of Medicinal Chemistry, University of Michigan

A Proteomic Approach to Identification of Prodrug-Activating Serine Hydrolases: Activation of Valacyclovir

Faculty Host: Gordon Amidon
January 13, 2020
2:00pm
NCRC Building 10, Room G065
Maria V. Fawaz
PhD Candidate, Oral Dissertation Defense Seminar
Department of Medicinal Chemistry, University of Michigan

Apolipoprotein A-I Mimetics for the Treatment of Niemann-Pick Disease

Faculty Host: Anna Schwendeman ( annaschw@umich.edu ) 763-4056
January 16, 2020
4:00pm
2548 NUB
Jake Hitchens
PhD Candidate, MedChem Student Seminar
Department of Medicinal Chemistry, University of Michigan

Exploration of Novel, CNS Penetrant Inhibitors of T. Gondii Cathepsin L

Faculty Host: Andy White ( whitandd@umich.edu ) 647-7374
Speaker Abstract
January 28, 2020
4:00pm
2548 NUB
Rachel Torrez
PhD Candidate, MedChem Student Seminar
Department of Medicinal Chemistry

Structural and functional analysis of human DICER1

Faculty Host: Amanda Garner ( algarner@umich.edu ) 763-2654
Speaker Abstract
January 30, 2020
4:00pm
2548 NUB
Garrett Dow
PhD Candidate, MedChem Student Seminar
Department of Medicinal Chemistry, University of Michigan

Targeting VirF, the Master Transcriptional Activator of Virulence in Shigella flexneri, as a novel route to treat Shigellosis

Faculty Host: George A. Garcia ( gagarcia@umich.edu ) 764.2202
Speaker Abstract
February 11, 2020
10:00am
Rackham Graduate School, West Conference Room
Rachel Rowlands
PhD Candidate, Oral Dissertation Defense Seminar
Department of Medicinal Chemistry, University of Michigan

Expanding the Arsenal: Development of G Protein-Coupled Receptor Kinase 5 Inhibitors Utilizing a Covalent Strategy

Faculty Host: Andy White ( whitandd@umich.edu ) 647-7374
February 13, 2020
4:00pm
2548 NUB
Robbie Hohlman
PhD Candidate, MedChem Student Seminar
Department of Medicinal Chemistry, University of Michigan

Exploration of Stig Cyclases as Biocatalytic Tools for Unnatural Indole Alkaloid Production

Faculty Host: David Sherman ( davidhs@umich.edu ) 615-9907
Speaker Abstract
February 18, 2020
4:00pm
2548 NUB
Yuning Shen
PhD Candidate, MedChem Student Seminar
Department of Medicinal Chemistry, University of Michigan

Novel Transformation Development of Acid–Amine Coupling Facilitated by Ultra-high Throughput Experimentation

Faculty Host: Tim Cernak ( tcernak@umich.edu ) 647-6793
Speaker Abstract
February 25, 2020
4:00pm
2548 NUB
Peter L. Toogood, PhD
Michigan Drug Discovery (MDD) Director, Life Sciences Institute; and Adjunct Professor of Medicinal Chemistry College of Pharmacy, University of Michigan

Small Molecule Immuno-Oncology Therapeutic Agents: RORγ Agonists for Treating Cancer

Faculty Host: Scott Larsen ( sdlarsen@umich.edu )
February 27, 2020
4:00pm
2548 NUB
Glory Velazquez
PhD Candidate, MedChem Student Seminar
Department of Medicinal Chemistry, University of Michigan

Antibiotic Discovery of Inhibitors of the CarD-RNA Polymerase Protein-Protein Interaction in Mycobacterium tuberculosis

Faculty Host: George Garcia ( gagarcia@umich.edu ) 764-2202
Speaker Abstract
March 12, 2020
4:00pm
2548 NUB
Jeffrey Aube, PhD
Fred Eshelman Distinguished Professor, Division of Chemical Biology and Medicinal Chemistry
School of Pharmacy, University of North Carolina at Chapel Hill

Revisiting Old Problems in Infectious Disease and Organic Chemistry

Faculty Host: Tim Cernak ( tcernak@umich.edu ) 647-6793
Speaker Website
May 13, 2020
2:00pm
BLUEJEANS.COM/ 287068993
Shuai Hu
PhD Candidate, Oral Dissertation Defense Seminar
Department of Medicinal Chemistry, University of Michigan

Discovery and Mechanistic Studies of Novel Redox Modulators for Treatment of Pancreatic Cancer

Faculty Host: Nouri Neamati, PhD ( neamati@med.umich.edu )
Speaker Abstract
October 8, 2020
4:00pm
Zoom Remote
Darci J. Trader, PhD
Assistant Professor of Medicinal Chemistry and Molecular Pharmacology
Purdue University; West Lafayette, IN

Methods to Evaluate and Perturb the Activity of the Human Proteasome with Small Molecules

Faculty Host: Prof. Amanda L. Garner, PhD ( algarner@umich.edu ) Student Host: Rachel Torrez ( torrezrm@umich.edu )
Speaker Website Speaker Abstract
October 15, 2020
4:00pm
Zoom Remote
Hosein Mohimani, PhD
Assistant Professor, Computational Biology Department, School of Computer Science
Carnegie Mellon University; Pittsburgh, PA

Computational methods for small molecule natural product discovery

Faculty Host: Prof. Roland Kersten ( rkersten@umich.edu )
Speaker Website Speaker Abstract
October 22, 2020
4:00pm
Zoom Remote
Jennifer C. Petter, PhD
Founder and Chief Scientific Officer
Arrakis Therapeutics; Waltham MA

Drugging RNA Structures with Small Molecules

Faculty Host: Prof. Amanda L. Garner, PhD ( algarner@umich.edu )
Speaker Website Speaker Abstract
November 5, 2020
4:00pm
Zoom Remote
Simone Brixius-Anderko, PhD
Research Fellow, Department of Medicinal Chemistry
College of Pharmacy, University of Michigan; Ann Arbor, MI

Understanding Aldosterone Biosynthesis for Enhanced Treatment of Hypertension

Faculty Host: Prof. Amanda L. Garner, PhD ( algarner@umich.edu )
Speaker Website Speaker Abstract
November 12, 2020
4:00pm
Zoom Remote
Alessandra S. Eustaquio, PhD
Assistant Professor, Department of Medicinal Chemistry and Pharmacognosy and Center for Pharmaceutical Biotechnology
College of Pharmacy, University of Illinois, Chicago (UIC)

From DNA to natural products through genetics

Faculty Host: Prof. Amanda L. Garner, PhD ( algarner@umich.edu )
Speaker Website Speaker Abstract
December 4, 2020
3:00pm
Zoom
Christine Cuthbertson
PhD Candidate, Oral Dissertation Defense Seminar
Department of Medicinal Chemistry, University of Michigan

Inhibition of Nucleotide and One-Carbon Metabolism for the Treatment of Cancer

Faculty Host: Nouri Neamati ( neamati@umich.edu )
Speaker Abstract
December 14, 2020
12:00pm
Zoom
Sean Tanzey
PhD Candidate, Oral Dissertation Defense Seminar
Department of Medicinal Chemistry, University of Michigan

Novel Approaches to PET Imaging Neurodegeneration

Faculty Host: Peter JH Scott ( pjhscott@med.umich.edu )
Speaker Abstract
January 26, 2021
4:00pm
Zoom Virtual
Luis Cervantes
Medicinal Chemistry Candidate, Third-Year Student Seminar
College of Pharmacy, Univeristy of Michigan

Large Scale Prediction of Relative Free Energies of Ligand Binding Using Multi-Site Lambda Dynamics (MSLD)

Faculty Host: Charles L. Brooks, III ( brookscl@umich.edu )
Speaker Abstract
January 28, 2021
4:00pm
Zoom Virtual
Troy Halseth
Medicinal Chemistry PhD Candidate; Third-Year Student Seminar
College of Pharmacy, University of Michigan

Apolipoprotein-Mimetics for the Treatment of Niemann-Pick Diseases

Faculty Host: Anna Schwendeman ( annschw@umich.edu )
Speaker Abstract
February 2, 2021
4:00pm
Zoom Virtual
Jinghan Liu
Medicinal Chemistry PhD Candidate; Third-Year Student Seminar
College of Pharmacy, University of Michigan

Structure and Function of Human Cytochrome P450 8B1

Faculty Host: Emily Scott ( scottee@umich.edu )
Speaker Abstract
February 9, 2021
4:00pm
Zoom virtual
Sean McCarty
Medicinal Chemistry PhD Candidate; Third-Year Student Seminar
College of Pharmacy, University of Michigan

Identification and Development of Novel Scaffolds for ꞵ-Cell Proliferation

Faculty Host: Jonathan Sexton ( jzsexton@umich.edu )
Speaker Abstract
February 11, 2021
4:00pm
Zoom Virtual
Andrew McGrath
Medicinal Chemistry PhD Candidate; Third-Year Student Seminar
College of Pharmacy, University of Michigan

Nontraditional Amine-Acid Coupling Reactions to Explore Structure-Function Relationships

Faculty Host: Tim Cernak ( tcernak@umich.edu )
Speaker Abstract
February 16, 2021
4:00pm
Zoom Virtual
Ryan Rutkoski
Medicinal Chemistry PhD Candidate; Third-Year Student Seminar
College of Pharmacy, University of Michigan

Development of Solid Supported Glycosyl Donors for the Glycosylation of Natural Products

Faculty Host: Pavel Nagorny ( nagorny@umich.edu )
Speaker Abstract
February 25, 2021
4:00pm
Zoom Virtual
Jesse Wotring
Medicinal Chemistry PhD Candidate, Third-Year Student Seminar
College of Pharmacy, University of Michigan

Accelerated Compound Repurposing Using High Content Imaging: Application to Non-Alcoholic Fatty Liver Disease

Faculty Host: Jonathan Sexton ( jzsexton@umich.edu )
Speaker Abstract
March 4, 2021
4:00pm
Zoom Virtual
Sherrice Zhang
Medicinal Chemistry PhD Candidate; Third-Year Student Seminar
College of Pharmacy, University of Michigan

Development of δ-Opioid Receptor (DOR) Positive Allosteric Modulators (PAMs) for the Treatment of Depression

Faculty Host: Andy White ( whitandd@umich.edu )
Speaker Abstract
March 9, 2021
4:00pm
Zoom Virtual
Yihao Zhuang
Medicinal Chemistry PhD Candidate, Third-Year Student Seminar
College of Pharmacy, University of Michigan

Discovery of Novel Natural Products that Inhibit eIF4E Protein-Protein Interactions

Faculty Host: Amanda Garner ( algarner@umich.edu )
Speaker Abstract
March 18, 2021
4:00pm
Zoom Virtual
Wenbin Tu
Medicinal Chemistry PhD Candidate, Third-Year Student Seminar
College of Pharmacy, University of Michigan

Development of PROTAC degraders of SMARCA proteins for the treatment of cancer

Faculty Host: Shaomeng Wang shaomeng@umich.edu
Speaker Abstract
March 19, 2021
1:00pm
Zoom Remote
Maha Hanafi
PhD Candidate, Department of Medicinal Chemistry
University of Michigan, Oral Dissertation Defense

Targeting Sigma-2 Receptor and ZFP91 in Pancreatic Cancer

Faculty Host: Nouri Neamati ( neamati@umich.edu )
Speaker Abstract
March 25, 2021
4:00pm
Zoom Virtual
Charles Zhang
Medicinal Chemistry PhD Candidate, Third-Year Student Seminar
College of Pharmacy, University of Michigan

Human Liver Organoids to Assess Idiosyncratic Drug-Induced Liver Injury

Faculty Host: Jonathan Sexton ( jzsexton@umich.edu )
Speaker Abstract
April 8, 2021
4:00pm
Zoom Remote
Rebecca T. Ruck, PhD
Executive Director of Enabling Technologies, Small Molecule PR&D
Merck Research Laboratories, Process Research & Development

Enabling Technologies for the green synthesis of Pharmaceutical Agents at Merck


Speaker Website Speaker Abstract
April 15, 2021
4:00pm
Zoom Remote:
Maud Reiter, PhD
Director of New & Renewable Ingredients, Research & Development Division
Firmenich S.A. in Geneva (Switzerland)

Firmenich’s quest towards sustainable muguet molecules

Faculty Host: Tim Cernak ( tcernak@umich.edu )
Speaker Website Speaker Abstract