Medicinal Chemistry 532
Bioorganic Principles of Medicinal Chemistry
(Credits: 2)

A mechanistic organic chemistry/biochemistry approach to medicinal chemistry, emphasizing macromolecular targets of drug action. The first of six sections focuses on receptors and ligand-receptor interactions, stressing energetics and stereochemical considerations. Section two deals with enzymes as drug targets, with emphasis on inhibitors of enzyme action. Section three explores metabolic pathways and mechanisms for xenobiotic transformation. Section four discusses DNA as a target for drug action and includes agents that interact with DNA directly and those that inhibit its synthesis. Section five covers the rationale behind pro-drug approaches as well as design strategies based on routes of bioactivation. Section six is a brief overview of biotechnology approaches with important benefits for drug discovery.

Prerequisites: Chemistry 540, Biochemistry 550, or permission of instructor
Instructor: Larsen
Terms: Fall
Medicinal Chemistry 533
Survey of Therapeutics
(Credits: 2)

Offered alternate Winter Terms. Survey of major drug classes with emphasis on molecular mechanisms of action.  Target identification with chemical probes.  

Prerequisites: Medicinal Chemistry 532 or permission of instructor
Instructor: Staff
Terms: Winter
Medicinal Chemistry 534
Drug Discovery
(Credits: 3)

Offered alternate Winter Terms. Survey of methods used in contemporary pharmaceutical research including computational and combinatorial approaches, and high-throughput analysis of drug efficacy and metabolism.

Prerequisites: Medicinal Chemistry 532, or permission of instructor
Instructor: Carlson
Terms: Winter
Medicinal Chemistry 535
Principles of Drug Design
(Credits: 2)

Sources of leads.  Lead selection from HTS and virtual screening.  General design principles.  Drug design with defined target structure.  Drug design without defined target structure.  ADMET Optimization.  Case Histories.  

Prerequisites: MedChem 532 or Permission of Instructor
Instructor: Larsen
Terms: Winter
Medicinal Chemistry 550
Ethics & Research [Cross-listed with Pharmacology 504]
(Credits: .5)

Ethics & Research 

Prerequisites: Permission of instructor
Instructor: Staff
Terms: Fall/Winter
Medicinal Chemistry 573
Investigations in Medicinal Chemistry
(Credits: 1-6)

Original investigation of a laboratory or library problem to be selected after consultation with the instructor. A paper is required.

Prerequisites: Permission of instructor
Instructor: Staff
Terms: Fall/Winter
Medicinal Chemistry 635
Advanced Topics
(Credits: 2)

Advanced Topics in Medicinal Chemistry 

Prerequisites: Medicinal Chemistry 532 and 533 or permission of instructor
Instructor: Staff
Terms: Fall/Winter
Medicinal Chemistry 660
Responsible Conduct of Research and Scholarship in Pharmaceutical Sciences at the University of Michigan
(Credits: 1 (half credit each term))

This course teaches students about ethics and integrity in science.  It takes advantage of case studies that link basic principles with specific examples, providing students with opportunities to discuss and develop concepts related to ethics and scientific integrity.  A major teaching tool will be the use of case studies where students discuss model cases and are challenged to apply their own knowledge as well as their personal experiences and insights in order to derive appropriate solutions to the problems posed.  This course is aimed at the predoctoral students at the College of Pharmacy. 

Prerequisites: Graduate students at the College of Pharmacy, with permission of instructor
Instructor: Woodard
Terms: Fall/Winter
Medicinal Chemistry 740
Preparing a Research Grant Proposal
(Credits: 1)

The course consists of several interactive lectures and workshops about the process of grant writing.  The students select a research topic for an NIH R21-type grant propsal, complete a draft, and present it to the class for peer feedback.  


Instructor: Soellner
Terms: Fall
Medicinal Chemistry 741
Defending an Original Research Proposal
(Credits: 1)

The students finalize the research proposal drafted in MedChem 740 and make an oral presentation to their committee.  

Prerequisites: MedChem 740
Instructor: Staff
Terms: Winter
Medicinal Chemistry 840
Medicinal Chemistry Seminar
(Credits: 1)

Weekly or Bi-weekly Medicinal Chemistry Seminar Series featuring lecturers from University of Michigan, or other outside institutions.  


Instructor: Staff
Terms: Fall/Winter
Medicinal Chemistry 990
Dissertation/Precandidacy
(Credits: 2-8)

Election for dissertation work by doctoral students not yet admitted to candidacy.

Prerequisites: Advanced doctoral student status
Instructor: Staff
Terms: Fall/Winter
Medicinal Chemistry 995
Dissertation/Candidacy
(Credits: 4-8)

Election for dissertation work by doctoral student admitted to candidacy.

Prerequisites: Doctoral candidacy
Instructor: Staff
Terms: Fall/Winter