Pharmaceutical Sciences 101
Intro to Drug Development
(Credits: 2)

This is an introductory course for undergraduates, primarily freshman and sophomore level students, who are interested in various aspects of the science behind the drug development process.  This course will cover the process of drug discovery and development, introduction to different aspects of basic and applied sciences involved in drug candidate identifications, and how candidate molecules are made into drugs and drug products in the clinic and market.

Prerequisites: College level introductory Chemistry, Physics, or Biology
Instructor: Staff
Terms: Winter
Pharmaceutical Sciences 211
Molecules to Drugs to Drug Products II
(Credits: 1)

This course provides in depth content covering many aspects of the science and engineering of pharmaceutical durg discovery, development, and manufacturing.  Pharmaceutical sciences 101 must have been taken previously or concurrently. 

Prerequisites: PharmSci 101 or concurrent enrollment
Instructor: Staff
Terms: Winter
Pharmaceutical Sciences 300
Biopharmaceutics and Biology of Drug Delivery
(Credits: 3)

This course serves as an introduction to pharmaceutical sciences.  It will cover biological and physico-chemical components related to pharmaceutical sciences, drug delivery, drug molecule movement in the body, and drug product performance and development, including biopharmaceutics and pharmacokinetics.  


Instructor: Staff
Terms: Fall
Pharmaceutical Sciences 400
Physical Chemistry of Drug Products
(Credits: 3)

Students will be taught basic concepts of Physcial Chemistry including solubility, stability, mass transfer, chemical kinetics and their application to the design of pharmaceutical dosage forms like tablets, injectable solutions, emulsions, cream and adhesive patches.  Application of basic pharmaceutics principles to the design of nanoparticle products, recombinant proteins and drug delivery approaches will be covered.  

Prerequisites: General Chemistry and Calculus I
Instructor: Staff
Terms: Fall
Pharmaceutical Sciences 402
Undergraduate Seminar PharmSci
(Credits: 1)

Students will be exposed to the wide range of contemporary research in pharmaceutical sciences, medicinal chemistry and clinical pharmacy.  Presenters will be University of Michigan or invited scientists and graduate students primarily from the College of Pharmacy.  Students are permitted to attend seminars from any of the three seminar programs offered by the College of Pharmacy.  

Prerequisites: This course is open to students entering their final year in the BSPS program
Instructor: Staff
Terms: Fall
Pharmaceutical Sciences 420
Medicinal Cannabis
(Credits: 2)

This course will cover all aspects related to the medicinal use of Cannabis, focusing on different perspectives offered by lecturers with highly relevant, related expertise.  Lecturers will include local scientists and physicians, Medical Cannabis doctors, dispensary owners, Cannabis lawyers, politicians, and students who are pursuing Cannabis-related careers.   

Prerequisites: Junior & Senior students or with permission. Successful completion of General Chemistry, Organic Chemistry (Chem 210/211) and Biology (Biology 172) required.
Instructor: Staff
Terms: Winter
Pharmaceutical Sciences 470
Undergraduate Research
(Credits: 1-6)

Research


Instructor: Staff
Terms: Fall/Winter
Pharmaceutical Sciences 499
BSPS Selected Topics
(Credits: 1-4)

Selected topics course in the undergraduate Pharmaceutical Sciences program. 

Prerequisites: BSPS students or permission to enroll
Instructor: Staff
Terms: Winter
Pharmaceutical Sciences 508
Drug Delivery and Solutions
(Credits: 3)

Basic principles of drug delivery are developed with respect to identifying and characterizing biological and physical-chemical barriers to the bioavailability of drugs.  Routes of drug delivery and related dosage forms are also introduced.  Specific emphasis is placed on building principles and solving problems in equilibria, transport, and chemical kinetics of drug solutions as they relate to liquid dosage form performance.

Prerequisites: Chemistry 216 and Physics 216
Instructor: Staff
Terms: Fall
Pharmaceutical Sciences 518
Drug Delivery and Drugs in Dispersed Systems and Solid Forms
(Credits: 3)

Course content includes the formulation, development and approval process of dosage forms comprised of disperesed phases (suspensions and emusions) and solid phases (amorphous and crystalline).  The course integrates physicochemical and concepts with quality and performance of topical, oral and inhalation dosage forms. 

Prerequisites: Pharmaceutical Sciences 508
Instructor: Staff
Terms: Winter
Pharmaceutical Sciences 519
Pharmaceutical Engineering [Cross-listed with Chemical Engineering 519]
(Credits: 3)

Offered in conjunction with the interdisciplinary Masters of Engineering in Pharmaceutical Engineering (M.Eng.) program, this course covers the concepts necessary to adapt engineering principles to pharmaceutical and life sciences related industries. Topics include process engineering in the drug discovery, high throughput characterization and optimization of new chemical entities, solid-state engineering, and intelligent pharmaceutical manufacturing systems. Lectures, problems, and Internet and library study will be used to develop the ideas presented.

Prerequisites: Senior or graduate standing, permission of instructor.
Instructor: Amidon
Terms: Winter
Pharmaceutical Sciences 568
Investigations in Pharmaceutics
(Credits: 1-6)

Original investigation of a laboratory or library problem to be selected after consultation with the instructor. A paper is required.

Prerequisites: Permission of instructor
Instructor: Staff
Terms: Fall/Winter
Pharmaceutical Sciences 570
Research
(Credits: 1-6)

The experiences will vary depending on the specific faculty member's project but may include: conducting clinical or basic science research, performing an extensive review of the literature and preparing a summary report/manuscript, analyzing data that has previously been collected. Students may work on a single project or be exposed to several types of projects during the course. For specific details of the course, students should contact individual faculty.

Prerequisites: PharmD students. Permission of instructor.
Instructor: Staff
Terms: Fall/Winter
Pharmaceutical Sciences 608
Pharmacokinetic Concepts and Applications
(Credits: 4)

This course is the third of four required courses in the pharmaceutical sciences curriculum.  Course content includes the absorption, distribution, metabolism, and excretion of drugs and drug-related species by the body.  Emphasis is placed on the use (not the derivation) of pharmacokinetic/dynamic models and equations.  Additional emphasis is placed on designing suitable dosage regimens for the treatment and prevention of disease in humans. Three lecture hours and one discussion hour a week.

Prerequisites: Pharmaceutical Sciences 518
Instructor: Staff
Terms: Fall
Pharmaceutical Sciences 700
Biopharmaceutics and Drug Disposition
(Credits: 2)

Offered alternate Fall Terms. This entry level course is designed for 1st or 2nd year graduate students in the pharmaceutical or related biomedical sciences.  The course focuses on the ADME concepts of absorption, distribution, metabolism, excretion, and basic pharmacokinetic/dynamic modeling, along with  transport, transporters, drug metabolism, and pharmacogenomics.   


Instructor: Smith
Terms: Fall
Pharmaceutical Sciences 701
Equilibria and Dosage Forms
(Credits: 2)

Offered alternate Fall Terms. This course focuses on the physical chemistry of drugs and drug delivery systems.  Thermodynamic principles, solution and interfacial phenomena, solubility, and solid state properties will be emphasized with a focus primarily on small molecules.  These physicochemical principles will be applied to the design, characterization, and performance of a variety of drug delivery systems.      

Prerequisites: Graduate student standing or permission of instructor
Instructor: Amidon
Terms: Fall
Pharmaceutical Sciences 702
Pharmaceutical Design, Delivery and Targeting – Biomolecular Concepts
(Credits: 2)

Offered alternate Fall Terms. This course focuses on the biological and molecular concepts of drug design, delivery and targeting.  The fundamental principles of cell biology and molecular biology will be applied to drug design, targeted drug delivery, and cellular drug delivery.

Prerequisites: Graduate student standing
Instructor: Lee
Terms: Fall
Pharmaceutical Sciences 703
Mass Transport and Chemical Kinetics
(Credits: 2)

Offered alternate fall terms.  This course focuses on the fundamentals of rate processes pertaining to drug delivery.  Rate processes will include both physical (i.e., mass transport processes) and chemical (i.e., degredation of drugs) rates.  An introduction to these concepts will be provided including both qualitative and quantitative treatment.  Regular problem sets will be assigned to re-inforce concepts discussed in class and in the assigned reading.  Mass transfer will be applied to drugs moving in solution, dissolving from solid dosage forms, and traversing polymer and biological membranes.  Decomposition of drugs will be examined in solution, in the solid state, and within dosage forms.       

Prerequisites: Math 216 Differential Equations completed or taken concurrently. Graduate student standing or permission of instructor.
Instructor: Schwendeman
Terms: Fall
Pharmaceutical Sciences 704
Analytical Methods in Drug Delivery
(Credits: 2)

The aim of this course is to present students with a broad range of topics and also in-depth treatment on selected analytical methods and techniques that have been used in the design and characterization of various pharmaceutical products: from small molecules to biologics. 

Prerequisites: Graduate student standing or permission of instructor
Instructor: Cheng
Terms: Fall
Pharmaceutical Sciences 705
Nanotechnology for Drug Delivery
(Credits: 2)

This course will detail recent advances made in the interdisciplinary field of nanomedicine for students with physical, chemical, or biological sciences background.  This course will focus on emerging nanotechnologies, and their biomedical applications, including nanomaterials, nanoparticle-based drug delivery systems, nano-based thranostics, and translation of nanomedicine into clinical trials and commercialization.  

Prerequisites: Graduate students or permission of instructor
Instructor: Staff
Terms: Winter
Pharmaceutical Sciences 706
Biologic Products: Recombinant Proteins, Cell Therapies and Biosimilars
(Credits: 2)

In 2016 the top selling drugs are monoclonal antibodies, and half of the new drugs approved are biopharmaceuticals and numerous biosimilars are being developed.  This class is about how biologic drugs are discovered, manufactured, formulated, analyzed, developed and regulated - now essential information for scientists seeking careers in the pharmaceutical industry.  

Prerequisites: Graduate students
Instructor: Schwendeman
Terms: Fall
Pharmaceutical Sciences 707
Pharmaceutical Solids
(Credits: 2)

Formation and properties of pharmaceutical solids. 

Prerequisites: Graduate student standing or senior undergraduate student standing. Completion of PharmSci 701, Chem 463, or equivalent.
Instructor: Staff
Terms: Winter
Pharmaceutical Sciences 709
PharmD Investigations - Research Proposal
(Credits: 1)

The first in a sequence of courses needed to complete the PharmD Investigations requirement.  This component of the series includes the written research proposal.  A grade will be submitted upon the successful submison and final approval of the proposal by the PharmD Investigations Committee.

Prerequisites: Third Year PharmD Students
Instructor: Staff
Terms: Fall
Pharmaceutical Sciences 710
Micropharmacokinetics: Cellular Drug Transport
(Credits: 2)

This course will teach students how to immerse themselves in the environment of cells: picoliter volumes with nanograms of materials containing a few femtomols of drug with hundreds of transporters pumping thousands of molecules per second.  

Prerequisites: Graduate student standing
Instructor: Staff
Terms: Winter
Pharmaceutical Sciences 717
Biopharmaceutical Engineering [Cross-listed with CHE 517 and MFG 517]
(Credits: 3)

This course covers fundamental concepts essential for the discovery, development, manufacturing, formulation and characterization of biopharmaceuticals.  Topics inlcude basic immunology, antibody discovery and engineering, emerging therapeutic modalities, vaccines, product quality and analytics, biosimilars, cell culture, purification and formulation.  

Prerequisites: Biology 172 or equivalent AND Che 330 or Biomede 221 or Chem 230, or graduate standing or enrollment in PharmD program
Instructor: Staff
Terms: Fall/Winter
Pharmaceutical Sciences 718
Modern Biopharmaceutics and Pharmacogenomics
(Credits: 2)

A course in Modern Biopharmaceutics and the recent advances in Pharmacogenetics and Genomics. The course will cover the oral absorption and metabolism of drugs from a classical and modern molecular perspective including discussion of current FDA Bioequivalence (BE) regulatory standards. It will also cover the most recent advances in pharmacogenomic and genetic test methods particularly as they relate to the selectivity and variability, in patients, of drug toxicity and efficacy.

Prerequisites: Third Year PharmD Students
Instructor: Staff
Terms: Winter
Pharmaceutical Sciences 719
PharmD Investigations - Research Data
(Credits: 2)

The second in a sequence of three courses needed for the PharmD Investigations requirement.  This semester of the series is designed for students to obtain hands on experience in conducting their research and collecting and analyzing all research data. Students work under the supervision of their faculty mentor to develop data collection forms and methods to archive data in a way that facilitates their analysis.

Prerequisites: Pharmaceutical Sciences PharmD Investigations - Research Proposal
Instructor: Staff
Terms: Winter
Pharmaceutical Sciences 737
Entrepreneurship in Pharmacy
(Credits: 1.5)

This team-based course will engage graduate and professional students in understanding and applying the basics of starting or operating a business in any pharmacy discipline, including ventures based on new drugs, new delivery systems, community pharmacy, or pharmacy healthcare.  Topics include business fundamentals, intellectual property, marketing, regulatory issues and more.  

Prerequisites: Graduate or Graduate Professional standing only
Instructor: Staff
Terms: Winter
Pharmaceutical Sciences 739 (formerly 585 )
PharmD Investigations - Research Report
(Credits: 1)

The third in a sequence of courses needed to complete the PharmD Investigations requirement.  This course in the series is designed for students to gain experience writing a research report, after completing data collection and analysis.  Students work under the supervision of their faculty mentor and submit the final report to the Investigations Committee.

Prerequisites: Pharmaceutical Sciences PharmD Investigations - Research Data
Instructor: Staff
Terms: Fall
Pharmaceutical Sciences 755
Advanced Topics
(Credits: 2)

Advanced Topics in Pharmaceutics


Instructor: Staff
Terms: Fall/Winter
Pharmaceutical Sciences 760
Advanced Pharmacokinetics and Biopharmaceutics
(Credits: 3)

Offered alternate Winter Terms. A continuation of the basic concepts introduced in PharmSci 518 (formerly 464) or PharmSci 700.  The course emphasizes the derivation and use of pharmacokinetic and pharmacodynamic equations, methods of data analysis, and computer applications including the use of WinNonlin and NONMEM.  One and one-half hour lectures are held twice a week.

Prerequisites: Math 216 (Differential Equations) and PharmSci 518 or 700 (Basic Pharmacokinetics); or permission of instructor. A course in statistics would be helpful.
Instructor: Smith
Terms: Winter
Pharmaceutical Sciences 838
Seminar in Pharmaceutics
(Credits: 1)

Reports on current studies in the field of Pharmaceutical Sciences.


Instructor: Staff
Terms: Fall/Winter
Pharmaceutical Sciences 990
Dissertation/Precandidacy
(Credits: 2-8)

Election for dissertation work by doctoral students not yet admitted to candidacy.

Prerequisites: Advanced doctoral student status
Instructor: Staff
Terms: Fall/Winter
Pharmaceutical Sciences 995
Dissertation/Candidacy
(Credits: 4-8)

Election for dissertation work by doctoral students admitted to candidacy.

Prerequisites: Doctoral candidacy
Instructor: Staff
Terms: Fall/Winter