Open Positions
1. Postdoctoral Research Fellows for LC-MS Analysis and Mass Spectrometry Imaging
Please send your application to Dr. Bo Wen ([email protected]), Assistant Director of Pharmacokinetics and Mass Spectrometry (PKMS) Core
The University Of Michigan College Of Pharmacy has 2-3 full-time opening for a research fellow in its Pharmacokinetics and Mass Spectrometry Core Facility (PKMS, www.pkcore.org). In this position, the candidates will learn strategies and techniques for LC-MS analysis, drug optimization and lead drug candidate selection, pharmacokinetics and drug metabolism, clinical sample analysis and clinical pharmacokinetics, and mass spectrometry imaging of small molecules, endogenous metabolites, lipids, proteins on tissue sections.
The successful candidate will independently perform the following research studies:
• LC-MS bioanalysis method development, validation, and samples analysis to clinical studies;
• metabolite identification using LC-MS/MS in microsomal incubation and in vivo biological matrix;
• mass spectrometry imaging of small molecules from tissue samples;
• quantitative LC-MS analysis of compounds in biological matrix of preclinical samples;
• preclinical and clinical pharmacokinetic analysis;
• in vivo animal PK study sampels analysis by working with animal team;
• targeted metabolomics studies for routine quantitation of well characterized metabolite, or untargeted metabolomics to discover biomarkers;
• independent preparation of study reports.
Required Qualifications
• PhD degree (with 0-3 years experience) in analytical chemistry, chemistry, pharmaceutical sciences, pharmacology and related field.
• LC-MS skill, knowledge, and experience for small or large molecules are required.
• The candidate should be a good team player with strong oral and written communication skills.
Desired Qualifications
• Knowledge and experience in metabolite identification and pharmacokinetics are preferred.
• Knowledge and experience in high resolution mass spectrometry, metabolomics, lipidomics and proteomics are preferred.
• Knowledge and experience in mass spectrometry imaging with MALDI, DESI and high resolution mass spectrometry is a plus.
• Ability to work closely with others in a small team setting.
2. Lab Technician for LC-MS Analysis and Mass Spectrometry Imaging
Please send your application to Dr. Bo Wen ([email protected]), Assistant Director of Pharmacokinetics and Mass Spectrometry (PKMS) Core
The University Of Michigan College Of Pharmacy has a full-time opening for for a laboratory technician in its Pharmacokinetics and Mass Spectrometry Core Facility (PKMS, www.pkcore.org). In this position, the candidates will learn strategies and techniques for LC-MS analysis, drug optimization and lead drug candidate selection, pharmacokinetics and drug metabolism, clinical sample analysis and clinical pharmacokinetics, and mass spectrometry imaging of small molecules, endogenous metabolites, lipids, proteins on tissue sections.
The successful candidate will independently perform the following routine studies and research studies:
Microsomal stability testing using LC-MS: Will develop, design and conduct liver microsomal stability experiments in line with the overall research plan, review progress and evaluate results (with supervision from the PI and senior members of the laboratory).
Quantitative LC-MS analysis of compounds in biological matrix of preclinical and clinical samples: Will be a contributor to multi- disciplinary project teams supporting early discovery programs or clinical trial through establishing LCMS-based assays to enable the discovery and development of high-quality small molecule therapeutics.
Preclinical and clinical pharmacokinetic analysis: Will review and study the data from preclinical and clinical quantitative analysis and interpretation of multi-source data to better characterize and differentiate compounds, thus adding value and enhancing the research.
Clinical biological sample preparation including plasma and biological fluids: Will entail establishing robust sample preparation protocols and developing targeted and untargeted MS acquisition methods suited for quantitative analysis of small molecular analytes within complex mixtures derived from biological matrices.
Independent preparation of study reports: Will make a data analysis for experiment results in final report.
Analyze samples sent to the lab using a variety of techniques, such as Electrospray, MALDI an LCMS; perform mass spectrometer maintenance. This includes calibration, keeping solvents and reference solutions filled, running performance checks on a daily basis
Required Qualifications
BS or MS in Analytical Chemistry, Chemistry, Pharmaceutical sciences, Chemical Biology, or related field
Desired Qualifications
LC-MS skill, knowledge, and experience for small molecules.
Strong oral and written communication skills.
Ability to work closely with others in a small team setting.
