Postdoctoral Fellow, Quantitative Systems Pharmacology

We seek a highly motivated individual with a Ph.D. in systems biology/pharmacology modeling, biochemical engineering or other related field. The postdoctoral fellow will be located at the University of Michigan, North Campus Research Complex in Ann Arbor (MI), a world-class center of pharmaceutical and biotech research. The position is within the Pharmacokinetics Core laboratory ( and includes collaborations with personnel across the cancer targeted research programs under the directorship of Dr. Duxin Sun (  The individual will build quantitative systems pharmacology model(s) to yield an understanding of how structural modifications alter biodistribution of novel chemical entities. The individual will work in a highly stimulating and multi-disciplinary environment and will have interactions with biologists, precision medicine scientists, clinical pharmacologists, and clinicians. In addition to computational model development, the individual will also have an opportunity to influence experimental designs towards data generation.



  • Create a multi-scale systems model describing biodistribution of novel chemical entities based on in-house data
  • Develop linkage between biodistribution and resulting in vivo tumor response
  • Apply data mining tools to obtain information on intracellular pathways relevant to cancer biology
  • Identify relevant data (in-vitro, in-vivo preclinical and clinical trial data) for model identification, optimization, and validation
  • Design experiments aimed towards generating data for model validation and testing of relevant hypotheses
  • Effectively communicate model results and outcomes to scientists in non-quantitative disciplines
  • Write scientific publications and present at internal and external scientific meetings

Requirements: Hands-on experience with modeling software like Simcyp, GastroPlus, MatLab/Simbiology, or NONMEM etc. is required


Interested applicants should apply online at, and submit a letter of intent, names of three referees and curriculum vitae to:

Manjunath (Amit) P. Pai, PharmD

Associate Professor of Clinical Pharmacy

Deputy Director of the PK Core

College of Pharmacy

North Campus Research Complex | B520-3352, 1600 Huron Parkway, Ann Arbor, MI 48109

Tel 734-647-0750 (PK Core)


Listing Row

Thursday, December 4, 2014
Thursday, December 4, 2014