Small-molecule NMR

To schedule a training please email Larisa Yeomans at [email protected]. 

Make sure you set aside 2 hours of your time for training.  In the basic training you will learn to run 1D experiments 1H, 13C, and one of the most useful 2D experiments, HSQC. Following the data acquisition you will be trained on data processing using Mestrenova.  The NMR laboratory has 2 perpetual licenses installed in the lab computers, and the university also has a site license.

Make sure that you have a decent quality NMR tube and that your deuterated solvents from an open bottle are not too old.  Deuterated solvents tend to absorb water with time after opening. Common deuterated NMR solvents include CDCl₃, methanol-d₄, acetone-d₆,  DMSO-d₆, D₂O, etc...  

DMSO-d₆ is a great solvent for NMR but you won´t be able to recover your sample, that is why I recommend you try to run your sample in a solvent that is easy to remove once you are done.

Great results will be obtained if you use 5-25mg of your compound and dissolve it in ~600 uL of deuterated solvent.   Lower volumes require longer shimming.  

NMR Tube care:

You should contact scientific glassblower Roy Wentz  [email protected]  (734)763-6357 at the Glass Shop 3416 in Chemistry, and purchase an NMR cleaning apparatus with your shortcode (~$100).  It really speeds up the cleaning process.   

Once they are clean, lay them flat on a piece of aluminum foil and let them dry in the oven (the oven should be set around 80-100 celsius)  for a couple hours.

Make sure you don´t leave the clean tubes in the oven for extended periods of time since that can compromise their shape.   A warped tube will give you deficient looking spectra.   

The instruments can be reserved by scheduling equipment time after you have logged into micores for the NMR lab.

Once you are trained you will be granted access to reserve instrument time for the 400MHz and the 500MHz. 

COLLEGE OF PHARMACY GRADUATE STUDENTS  AND RESEARCH STAFF HAVE RESERVATION PRIORITY

The 400MHz can be reserved up to an hour from 8:00am-7:00pm during the week and after that you can reserve freely for overnight runs.  You can reserve for as long as you need to over the weekend.

The 500MHz can be reserved freely.

We also offer sample service, in that case you can bring your sample prepared or we can prepare it for you. At the end you will get your raw data send to you via email or dropbox.  If you want to submit a service request please log into micores and submit your request.

Hands on:

400 MHz
University of Michigan Investigators - $16 per hour (billed in 15 minutes increments)
External Users - $60 per hour

500 MHz
University of Michigan Investigators - $22 per hour (billed in 15 minutes increments)
External Users - $70 per hour

Consulting rate

Internal- $80 per hour

External- $100 per hour

If Spectroscopist Performs the Experiments:

Internal: $39 (sample service fee per sample) in addition to hourly fee for machine usage

External: $50 (sample service fee per sample) in addition to hourly fee for machine usage