Development of fragment screening platform for efficient targeting of challenging proteins

Development of Fragment Screening Platform for Efficient Targeting ofChallenging Proteins
Tomasz Cierpicki, Medicine; Matt Soellner, Pharmacy; Jolanta Grembecka, Medicine

Fragment-based drug discovery (FBDD) has been recognized as a powerful, alternative approach to hit identification in drug discovery. Efforts in FBDD field have already resulted in compounds that represent clinical candidates for difficult protein targets. Fragment screening has a great potential to rapidly identify very promising hits and is particularly promising for development of small molecule ligands for challenging proteins where the standard biochemical assays have limited applications.