Appendix
University of Michigan Location
Ann Arbor
The vibrant and active city of Ann Arbor is consistently rated as one of the nation’s top college towns. In addition to its world-class university, Ann Arbor is home to high-tech research companies and charming neighborhoods with a rich mix of cultures. Downtown Detroit—with its eclectic mix of entertainment and professional sports—is less than an hour’s drive away, and Detroit Metro Airport (DTW) offers a nearby gateway to the globe.
University of Michigan Leadership
Mark Schlissel, M.D., PhD, is the 14th president of the University of Michigan and the first physician-scientist to lead the institution. Since beginning as president in July 2014, he has launched initiatives including Academic Innovation; Biosciences; Diversity, Equity, and Inclusion; Poverty Solutions; and Precision Health. As part of his commitment to college affordability, President Schlissel announced the Go Blue Guarantee in June 2017, a financial aid program that provides up to four years of free undergraduate tuition to in-state students from families in Michigan making $65,000 or less.
Susan Collins, PhD, is provost and executive vice president for academic affairs at the University of Michigan. She joined the Michigan faculty in 2007, serving as the Joan and Sanford Weill Dean of the Gerald R. Ford School of Public Policy until 2017 and becoming the provost in 2020. Currently, she is the Edward M. Gramlich Collegiate Professor of Public Policy as well as professor of economics in the College of Literature, Science, and the Arts. As an international macroeconomist, Dr. Collins has a lifelong interest in understanding and fostering policies to improve living standards in countries at all levels of development. Her research has examined determinants of economic growth, the roles of China and India in the global economy, cross-border financial integration, and linkages between trade and labor markets, among other topics.
The university is governed by the Board of Regents, which consists of eight members elected at large in biennial statewide elections. The president of the university serves as an ex officio member of the board. The Regents serve without compensation for overlapping terms of eight years. According to the Michigan Constitution of 1963, the university has constitutional autonomy from the state of Michigan; under such terms, the Regents have “general supervision” of the institution and “the control and direction of all expenditures from the institution’s funds.”
College of Pharmacy
Core Values
Respect · Excellence · Leadership · Diversity · Community · Integrity · Professionalism · Innovation
Research Cores and Services
- Biochemical Nuclear Magnetic Resonance Laboratory
Biochemical Nuclear Magnetic Resonance Laboratory
(https://cores.research.umich.edu/core/biochemical-nmr-core/ )The Biochemical Nuclear Magnetic Resonance (BNMR) Laboratory provides research support for graduate students, postdocs, and faculty. Hands-on experiences are encouraged following a straightforward training and services of running samples are also offered. Staff assists with structure elucidation, experiments design, data processing, and more. Quantitative metabolomics NMR services are offered for different biological fluids including whole blood, serum, plasma, urine, cell media.
- Clinical Pharmacogenomics Laboratory
Clinical Pharmacogenomics Laboratory
(https://pharmacy.umich.edu/cpl)The CoP houses the Clinical Pharmacogenomics Laboratory, which primarily serves a research mission. Expansion of this core lab is currently underway in collaboration with the University of Michigan Health Systems for the purpose of introducing personalized medicine within the U-M hospital and clinics. This advancement in pharmacy practice is still in its beginning stages; it will incorporate not only existing care models, but also emerging pharmacy practice models through the use of collaborative practice agreements.
- Nuclear Magnetic Resonance (NMR) Metabolomics Laboratory
Nuclear Magnetic Resonance (NMR) Metabolomics Laboratory
(https://pharmacy.umich.edu/nmr/nmr-metabolomics)The CoP houses the NMR Metabolomics Laboratory which serves as a vantage point for metabolomics research. The laboratory routinely utilizes the Biochemical NMR Laboratory to run quantitative metabolomics on numerous biofluids including whole blood, serum, plasma, urine, cell media. The laboratory also liaisons between NMR and LC-MS analytical platforms in close collaboration with the university’s metabolomics core facility (https://brcf.medicine.umich.edu/cores/metabolomics/).
- Pharmacokinetics and Mass Spectrometry Core
Pharmacokinetics and Mass Spectrometry Core
(https://cores.research.umich.edu/core/pharmacokinetic-and-mass-spectrometry-core/)The Pharmacokinetics and Mass Spectrometry (PKMS) Core aims to facilitate researchers' efforts to discover new medicines, obtain research funding, file patent applications, and publish academic research findings. The pharmacokinetics and mass spectrometry (PKMS) core plays a pivotal role in advancing the drug discovery, clinical translation, and optimization of novel and existing therapeutics. PKMS core has eight LC-MS instruments that include three MS with high resolution MS capability and two MS with mass spectrometry imaging capability. The PKMS core has a thirteen-year track record of supporting: (1) quantitative LC-MS analysis of molecules and mass spectrometry imaging of spatial localization biomarkers in tissue section; (2) preclinical ADME and pharmacokinetics for lead compound optimization in drug discovery and development; (3) clinical pharmacokinetics and dosage regimen design for clinical trials. In the core's short history, we have supported LC-MS analysis, pre-clinical ADME and PK of more than 6500 compounds; supported clinical pharmacokinetics of more than 55 compounds in clinical trials. We have contributed to more than 310 grant applications, in which 101 grants were funded with total funding of $260 million to the University of Michigan.
- Vahlteich Medicinal Chemistry Core
Vahlteich Medicinal Chemistry Core
(https://cores.research.umich.edu/core/vahlteich-medicinal-chemistry-core-vmcc/)The VMCC is an on-campus facility that designs and synthesizes drug-like molecules and diagnostic probes for biomedical investigations. The center is staffed with individuals with over 100 years of collective experience in the pharmaceutical industry. VMCC´s capabilities include organic synthesis, design of molecular probes and drug-like molecules, analysis of structure-activity relationships (SAR), triage of high throughput screening (HTS) data for the selection and follow-up of promising leads, improvement of ADMET (Absorption, Distribution, Metabolism, Excretion, Toxicity) properties of lead compounds, structure and ligand-based computational methods, and patentability of chemical matter.
Centers
- Center for Chemical Genomics
Center for Chemical Genomics
(https://www.lsi.umich.edu/science/centers-technologies/center-chemical-genomics )The CCG provides assistance with assay development for implementation into high throughput screening. Resources include a small molecule compound collection, liquid handling robotics, detection equipment, relational database, and chemistry software for follow-up development.
- Michigan Center for Interprofessional Education
Michigan Center for Interprofessional Education
(https://interprofessional.umich.edu/)The Center for Interprofessional Education seeks to foster a growing menu of IPE of learning opportunities for University of Michigan students that includes not only traditional semester-based courses, but also clinical and field experiences, service learning, simulations, online learning modules, and more.
- Michigan Drug Discovery
Michigan Drug Discovery
(https://drugdiscovery.umich.edu/about/ )Michigan Drug Discovery is a university-spanning collaboration to find, fund, and mentor drug discovery projects originating from faculty research across a sweeping range of disease areas. U-M investigators’ vast experience in areas of unmet medical needs is supported with complementary expertise and technology in every step of the drug discovery process. Staff provide guidance, strategy, and coordination of the university’s full drug discovery resources. Support is given by an executive committee and an external advisory board representing scientific, medical, and commercialization experts in the field of drug discovery.
- Natural Products Discovery Core
Natural Products Discovery Core
(Natural Products Discovery Core | Life Sciences Institute (umich.edu)Roughly half of the drugs in clinical use today started as natural products — molecules that evolved inside microorganisms and plants that form the backbone of antibiotics, anti-cancer agents and other medicines. Over the past decade, the University of Michigan has become a leader in natural product sciences. The LSI's Natural Products Discovery Core has developed a 45,000-sample (and growing) library of natural product extracts derived from a unique collection of diverse marine and terrestrial actinomycetes, fungi and cyanobacteria. The core provides researchers at U-M and external partners with the technology and expertise to develop candidates identified through high-throughput screening into unique, bioactive, patentable, small molecules.
Rapid genomic and metabolomic profiling allows users to identify high value molecules as probes and drug leads. Recent investments by the U-M Biosciences Initiative will add state-of-the-art mass spectrometry and NMR resources for structure elucidation, as well as the recruitment of new faculty and specialists.
