Summary

Dr. Smith is the John G. Wagner Collegiate Professor of Pharmaceutical Sciences at the University of Michigan, College of Pharmacy, and a member of the Comprehensive Cancer Center and Michigan Gastrointestinal Peptide Research Center in the School of Medicine.  He served as Founding Chair, Department of Pharmaceutical Sciences, from 1999-2010.  Dr. Smith received his B.S. in Pharmacy (1975) from the State University of New York at Buffalo and his Ph.D. in Pharmaceutical Chemistry (1981) from the University of California San Francisco.  Upon completing his doctoral thesis, he joined the faculty at the University of Michigan as an Assistant Professor of Pharmacy.  Dr. Smith is a Fellow of the American Association of Pharmaceutical Scientists (1998) and the American Association for the Advancement of Science (2012), and served on the Pharmacology Study Section of the National Institutes of Health (1998-2002).  He received the James R. Gillette Drug Metabolism and Disposition Best Paper Award from the American Society for Pharmacology and Experimental Therapeutics on two separate occasions (2002 and 2008).  In 2003, he received both the College of Pharmacy Teaching Excellence Award and the Student Appreciation Award.  Dr. Smith is a member of several scientific and professional organizations (e.g., AAAS, AACP, AAPS, APhA, ASPET, ISSX) and is an Editor of Pharmaceutical Research.  During his career, he has made many important scientific contributions, including those on the kinetic-dynamic relationship of loop diuretics, the determinants of renal drug elimination, the regional pharmacokinetics of anticancer drugs, and the cellular and molecular biology, physiology and pharmacology of proton-coupled oligopeptide transporters.  

Research Interests

  • Pharmacokinetics and biopharmaceutics

  • Drug transport mechanisms and transporters

  • Cellular and molecular biology, physiology, and pharmacology of proton-coupled oligopeptide transporters

  • Role of PepT1 in the intestinal absorption, disposition, and dynamics of peptides, mimetics, and peptide-like drugs

  • Role of PepT2 in peptide/mimetic disposition-dynamics in the brain and kidney

  • Role of PhT1 in peptide/mimetic and histidine disposition in brain

Awards

  • 1998 Fellow, American Association of Pharmaceutical Scientists
  • 2002 James R. Gillette Best Paper Award, American Society for Pharmacology and Experimental Therapeutics
  • 2008 James R. Gillette Best Paper Award, American Society for Pharmacology and Experimental Therapeutics
  • 2016 Invited Professorship Appointment (one month)
  • 2017 Fulbright U.S. Scholar Program*

Selected Publications

  • Smith DE, Clemençon B, Hediger MA. Proton-coupled oligopeptide transporter family SLC15: Physiological, pharmacological and pathological implications. Mol Aspects Med 34:323-336, 2013.

  • Posada MM, Smith DE. Relevance of PepT1 in the intestinal permeability and oral absorption of cefadroxil. Pharm Res 30:1017-1025, 2013.

  • Wu SP, Smith DE. Impact of intestinal PepT1 on the kinetics and dynamics of N-formyl-methionyl-leucyl-phenylalanine, a bacterially-produced chemotactic peptide. Mol Pharm 10:677-684, 2013.

  • Wu SP, Smith DE. Impact of intestinal PepT1 on the kinetics and dynamics of N-formyl-methionyl-leucyl-phenylalanine, a bacterially-produced chemotactic peptide. Mol Pharm 10:677-684, 2013.

  • Wu SP, Smith DE. Impact of intestinal PepT1 on the kinetics and dynamics of N-formyl-methionyl-leucyl-phenylalanine, a bacterially-produced chemotactic peptide. Mol Pharm 10:677-684, 2013.