Summary

Dr. David E. Smith is the John G. Wagner Collegiate Professor of Pharmaceutical Sciences at the University of Michigan, College of Pharmacy, and a member of the Comprehensive Cancer Center and Michigan Gastrointestinal Peptide Research Center in the School of Medicine. He served as Founding Chair of the Department of Pharmaceutical Sciences from 1999-2010. Dr. Smith received his B.S. in Pharmacy from the State University of New York at Buffalo (1975) and his Ph.D. in Pharmaceutical Chemistry from the University of California San Francisco (1981).  Upon completing his doctoral thesis, he joined the faculty at the University of Michigan as an Assistant Professor of Pharmacy. Dr. Smith is a Fellow of both the American Association of Pharmaceutical Scientists (1998) and the American Association for the Advancement of Science (2012). He served on the Pharmacology Study Section of the National Institutes of Health from 1998-2002. Dr. Smith received the James R. Gillette Drug Metabolism and Disposition Best Paper Award from the American Society for Pharmacology and Experimental Therapeutics on two separate occasions (2002 and 2008), and served as Editor of the journal Pharmaceutical Research (2001-2017). In 2003, he received both the College of Pharmacy Teaching Excellence Award and the Student Appreciation Award. Dr. Smith has 156 publications in prominent journals and books, and over 140 invited presentations to academic institutions, pharmaceutical and biotechnology industries, and regulatory agencies. During his career, Dr. Smith made many important scientific contributions, including those on the kinetic-dynamic relationship of loop diuretics, the determinants of renal drug elimination, the regional pharmacokinetics of anticancer drugs, and the cellular and molecular biology, physiology and pharmacology of proton-coupled oligopeptide transporters. Dr. Smith is most proud of the 33 doctoral students, 11 postdoctoral fellows and visiting scholars, and 17 professional pharmacy students he has mentored over the years, and who continue to add scholarship, understanding and insight to the pharmaceutical, biomedical and clinical sciences.  

Research Interests

  • Biopharmaceutics, pharmacokinetics and pharmacodynamics

  • Drug transport mechanisms and transporters

  • Cell and molecular biology, physiology and pharmacology of proton-coupled oligopeptide transporters

Awards

  • 2016 Invited Professorship Appointment (one month), University of Paris Descartes, France
  • 2012 Fellow, American Association for the Advancement of Science
  • 2008 James R. Gillette Drug Metabolism and Disposition Best Paper Award, American Society for Pharmacology and Experimental Therapeutics
  • 2003 Teaching Excellence Award, College of Pharmacy, University of Michigan
  • 2003 Student Appreciation Award, College of Pharmacy, University of Michigan
  • 2002 James R. Gillette Drug Metabolism and Disposition Best Paper Award, American Society for Pharmacology and Experimental Therapeutics
  • 1998 Fellow, American Association of Pharmaceutical Scientists

Selected Publications

  • Thompson BR, Hu Y, Smith DE. Mechanisms of gemcitabine oral absorption as determined by in situ intestinal perfusions in mice. Biochem Pharmacol 168:57-64, 2019.

  • Hu Y, Song F, Jiang H, Nuñez G, Smith DE. SLC15A2 and SLC15A4 mediate the transport of bacterially-derived di/tripeptides to enhance the NOD-dependent immune response in mouse bone marrow-derived macrophages. J Immunol 201:652-662, 2018.

  • Hu Y, Xie Y, Wang Y, Chen X, Smith DE. Development and characterization of a novel mouse line humanized for the intestinal peptide transporter PEPT1. Mol Pharm 11:3737-3746, 2014.

  • Hu Y, Smith DE, Ma K, Jappar D, Thomas W, Hillgren KM. Targeted disruption of peptide transporter Pept1 gene in mice significantly reduces dipeptide absorption in intestine. Mol Pharm 5:1122-1130, 2008.

  • Shen H, Smith DE, Keep RF, Xiang J, Brosius III FC. Targeted disruption of the PEPT2 gene markedly reduces dipeptide uptake in choroid plexus. J Biol Chem 278:4786-4791, 2003.