Summary

Gregory Amidon received his BS in medicinal chemistry and his PhD in pharmaceutical chemistry from the University of Michigan. After 28 years in the pharmaceutical industry, he returned to the College of Pharmacy in 2007 as a research professor of pharmaceutical sciences. He currently directs the Pharmaceutical Engineering program, jointly sponsored by the College of Engineering and the College of Pharmacy. 

He has held various research positions in R&D and is recognized for his expertise in the physical, chemical, and mechanical property characterization of active pharmaceutical ingredients, excipients, and products as well as the development of scientific strategies for oral solid dosage form development. 

Professor Amidon has served on the USP Council of Experts since 1990 and currently chairs the General Chapters – Physical Analysis Expert Committee. He is a member and Fellow of the American Association of Pharmaceutical Scientists (AAPS).  He is currently President-Elect of AAPS (2014-2015).  Dr. Amidon is also a recipient of the Ebert Prize from the American Pharmaceutical Association and the 2014 AAPS Research Achievement Award in Physical Pharmacy and Biopharmaceutics.

Research Interests

  • Oral bioperformance assessment

  • The utilization of cocrystals to enhance oral drug delivery

  • Characterizing the physical, chemical, and mechanical properties of pharmaceutical solids

Selected Publications

  • DM Mudie, Y Shi, H Ping, P Gao, GL Amidon, GE Amidon, “Mechanistic Analysis of Solute Transport in an In Vitro Physiological Two-Phase Dissolution Apparatus”, Biopharm Drug Dispos, 33(7):378-402 (2012).

  • J Miller, A Beiq, BJ Krieg, R Carr, GE Amidon, GL Amidon, A Dahan, “The Solubility-Permeability Interplay: Mechanistic Modeling and Predictive Application of the Impact of Micellar Solubilization on Intestinal Permeation”, Molecular Pharmaceutics, 8:1848-56 (2011).

  • DM Mudie, GL Amidon, GE Amidon, “Physiological Parameters for Oral Delivery and In Vitro Testing”, Molecular Pharmaceutics, 7(5):1388-1405 (2010).

  • RM Iyer, GE Amidon, “The Impact of Hot Melt Extrusion and Spray Drying on Mechanical Properties and Tableting Indices of Materials Used in Pharmaceutical Development”, Journal of Pharmaceutical Sciences 102(10) 3604-3613. (2013).

  • C Maheshwari, A Jayasankar, N AKhan, GE Amidon, N Rodríguez-Hornedo,” Factors that Influence the Spontaneous Formation of Pharmaceutical Cocrystals by Simply Mixing Solid Reactants”, Cryst. Eng Comm 11(3) 493-500. (2009).

Recent Publications

  • Lawrence X. Yu; Ilgaz Akseli; Barbara Allen; Gregory Amidon; Tara Gooen Bizjak; Ashley Boam; Margaret Caulk; David Doleski; Joseph Famulare; Adam C. Fisher; Scott Furness; Brian Hasselbalch; Henry Havel; Stephen W. Hoag; Robert Iser; Bruce D. Johnson; Robert Ju; Paula Katz; Emanuela Lacana; Sau L. Lee; Richard Lostritto; Grace McNally; Mehul Mehta; Ganapathy Mohan; Moheb Nasr; Roger Nosal; Mary Oates; Thomas O’Connor; Jim Polli; G. K. Raju; Mahesh Ramanadham; Giuseppe Randazzo; Susan Rosencrance; Anna Schwendeman; Arzu Selen; Paul Seo; Vinod Shah; Ramesh Sood; Michael P. Thien; Tony Tong; Bernhardt L. Trout; Katherine Tyner; Siva Vaithiyalingam; Martin VanTrieste; Fionnuala Walsh; Russell Wesdyk; Janet Woodcock; Geoffrey Wu; Larisa Wu; Louis Yu; Diane Zezza Advancing Product Quality. AAPS Journal. 2016;18(2):528-543
  • Lawrence X. Yu; Ilgaz Akseli; Barbara Allen; Gregory Amidon; Tara Gooen Bizjak; Ashley Boam; Margaret Caulk; David Doleski; Joseph Famulare; Adam C. Fisher; Scott Furness; Brian Hasselbalch; Henry Havel; Stephen W. Hoag; Robert Iser; Bruce D. Johnson; Robert Ju; Paula Katz; Emanuela Lacana; Sau L. Lee; Richard Lostritto; Grace McNally; Mehul Mehta; Ganapathy Mohan; Moheb Nasr; Roger Nosal; Mary Oates; Thomas O’Connor; Jim Polli; G. K. Raju; Mahesh Ramanadham; Giuseppe Randazzo; Susan Rosencrance; Anna Schwendeman; Arzu Selen; Paul Seo; Vinod Shah; Ramesh Sood; Michael P. Thien; Tony Tong; Bernhardt L. Trout; Katherine Tyner; Siva Vaithiyalingam; Martin VanTrieste; Fionnuala Walsh; Russell Wesdyk; Janet Woodcock; Geoffrey Wu; Larisa Wu; Louis Yu; Diane Zezza Advancing Product Quality. AAPS Journal. 2016;18(2):528-543
  • Kazuki Matsui; Yasuhiro Tsume; Gregory E. Amidon; Gordon L. Amidon The Evaluation of In Vitro Drug Dissolution of Commercially Available Oral Dosage Forms for Itraconazole in Gastrointestinal Simulator With Biorelevant Media. Journal of Pharmaceutical Sciences. 2016;105(9):2804-2814
  • Gregory E. Amidon; Ilgaz Akseli; David Goldfarb; Xiaorong He; Changquan C. Sun; Hong Wang USP responses to comments on stimuli article proposed new usp general information chapter "Tablet Compression Characterization <1062>". Pharmacopeial Forum. 2016;42(5):
  • Fengjuan Cao; Gordon L. Amidon; Nair Rodriguez-Hornedo; Gregory E. Amidon Mechanistic Analysis of Cocrystal Dissolution as a Function of pH and Micellar Solubilization. Molecular Pharmaceutics. 2016;13(3):1030-1046