2019 Publications

  1. Kahl DJ, Hutchings KM, Lisabeth EM, Haak AJ, Leipprandt JR, Dexheimer T, Khanna D, Tsou PS, Campbell PL, Fox DA, Wen B, Sun D, Bailie M, Neubig RR, Larsen SD. 5-Aryl-1,3,4-oxadiazol-2-ylthioalkanoic Acids: A Highly Potent New Class of Inhibitors of Rho/Myocardin-Related Transcription Factor (MRTF)/Serum Response Factor (SRF)-Mediated Gene Transcription as Potential Antifibrotic Agents for Scleroderma. J Med Chem. 2019 Apr 18. [Epub ahead of print] PMID:30951312.
  2. Dai W, Samanta S, Xue D, Petrunak EM, Stuckey JA, Han Y, Sun D, Wu Y, Neamati N. Structure-Based Design of N-(5-Phenylthiazol-2-yl) acrylamides as Novel and Potent Glutathione S-Transferase Omega 1 Inhibitors. 2019 Mar 28;62(6):30688-3087. PMID: 30735370.
  3. Seekatz AM, Schnizlein MK, Koenigsknecht MJ, Baker JR, Hasler WL, Bleske BE, Young VB, Sun D. Spatial and Temporal Analysis of the Stomach and Small-Intestinal Microbiota in Fasted Healthy Humans. mSphere. 2019 Mar 13;4(2). PMID: 30867328.
  4. Baker JR, Dickens JR, Koenigsknecht M, Frances A, Lee AA, Shedden KA, Brasseur JG, Amidon GL, Sun D, Hasler WL. Propagation Characteristics of Fasting Duodeno-Jejunal Contractions in Healthy Controls Measured by Clustered Closely-spaced Manometric Sensors. Journal Neurogastroenterol Motility. 2019 Jan 31;25(1):100-112. PMID: 30646481.
  5. Sun L, Yuan H, Burnett J, Gasparyan M, Zhang Y, Zhang F, Yang Z, Ran Y, Sun D. MEOX1 Promotes Tumor Progression and Predicts Poor Prognosis in Human Non-Small-Cell Lung Cancer. International Journal of Medical Sciences. 2019 Jan 1;16(1):68-74. PMID: 30662330.

2018 Publications

  1. Paixao P, Bermejo M, Hens B, Tsume Y, Dickens J, Shedden K, Salehi N, Koenigsknecht MJ, Baker JR, Hasler WL, Lionberger R, Fan J, Wysocki J, Wen B, Lee A, Frances A, Amidon GE, Yu A, Benninghoff G, Lobenberg R, Talattof A, Sun D, Amidon GL. Linking the Gastrointestinal Behavior of Ibuprofen with the Systemic Exposure between and within Humans-Part 2: Fed State. Molecular Pharmceutics. 2018 Dec 3;15(12):5468-5478. PMID: 30417648.
  2. Bermejo M, Paixao P, Hens B, Tsume Y, Koenigsknecht MJ, Baker JR, Hasler WL, Lionberger R, Fan J, Dickens J, Shedden K, Wen B, Wysocki J, Lobenberg R, Lee A, Frances A, Amidon GE, Yu A, Salehi N, Talattof A, Benninghoff G, Sun D, Kuminek G, Cavanagh KL, Rodriguez-Hornedo N, Amidon GL. Linking the Gastrointestinal Behavior of Iburprofen with the Systemic Exposure between and within Humans-Part 1: Fasted State Conditions. Molecular Pharmaceutics. 2018 Dec 3;15(12):5454-5467. PMID: 30372084.
  3. Li YF, Zhang C, Zhou S, He M, Zhang H, Chen N, Li F, Luan X, Pai M, Yuan H, Sun D, Li Y. Species difference in paclitaxel disposition correlated with poor pharmacological efficacy translation from mice to humans. Clinical Pharmacology. 2018 Nov 8;10:165-174. PMID: 30519122.
  4. Yu J, Chen J, Zhao H, Gao J, Li Y, Li Y, Xue J, Dahan A, Sun D, Zhang G, Zhang H. Integrative proteomics and metabolomics analysis reveals the toxicity of cationic liposomes to human normal hepatocyte cell line L02. Mol Omics. 2018 Oct 8;14(5):362-272. PMID: 30247494.
  5. Li F, Zhang H, He M, Liao J, Chen N, Li Y, Zhou S, Palmisano M, Yu A, Pai MP, Sun D. Different nanoformulations alter the tissue distribution of paclitaxel, which aligns with reported distinct efficacy and safety profiles. Molecular Pharmaceutics. 2018 Oct 1;15(10):4505-4516 [Epub ahead of print] PMID: 30180593.
  6. Huddle BC, Grimley E, Buchman CD, Chtcherbinine M, Debnath B, Mehta P, Yang K, Morgan CA, Li S, Felton J, Sun D, Mehta G, Neamati N, Buchanovich RJ, Hurley TD, Larsen SD. Structure-based optimization of a novel class of aldehyde dehydrogenase 1A (ALDH1A) subfamily-selective inhibitors as potential adjuncts to ovarian cancer chemotherapy. J Med Chem. 2018 Sep 28. [Epub ahead of print] PMID: 30221940.
  7. Lin CC, Lo MC, Moody R, Jiang H, Harouaka R, Stevers N, Tinsley S, Gasparyan M, Wicha M, Sun D. Targeting LRP8 inhibits breast cancer stem cells in triple-negative breast cancer. Cancer Lett. 2018 Sep 15;438:165-173. [Epub ahead of print] PMID: 30227220.
  8. Tsume Y, Patel S, Fotaki N, Bergstrom C, Amidon GL, Brasseur JG, Mudie DM, Sun D, Bermejo M, Gao P, Zhu W, Sperry DC, Vertzoni M, Parrott N, Lionberger R, Kambayashi A, Hermans A, Lu X, Amidon GE. In vivo predictive dissolution and simulation workshop report: facilitating the development of oral drug formulation and the prediction of oral bioperformance. AAPS Journal. 2018 Sep 6;20(6):100. PMID: 30191341.
  9. Luan X, Guan YY, Liu HJ, Lu Q, Zhao M, Sun D, Lovell JF, Sun P, Chen HZ, Fang C. A tumor vascular-targeted interlocking trimodal nanosystem that induces and exploits hypoxia. Advanced Science. 2018 May 28;5(8):1800034. PMID: 30128230.
  10. Paixao P, Bermejo M, Hens B, Tsume Y, Dickens J, Shedden K, Salehi N, Koenigsknecht MJ, Baker JR, Hasler WL, Lionberger R, Fan J, Wysocki J, Wen B, Lee A, Frances A, Amidon GE, Yu A, Benninghoff G, Lobenberg R, Talattof A, Sun D, Amidon GL.  Gastric Emptying and intestinal appearance of nonabsorbable drugs phenol red and paromomycin in human subjects: A multi-compartment stomach approach. Eur J Pharm Biopharm. 2018 Aug;129:162-174. PMID:29857136.
  11. Zhao Y, Zhou B, Bai L, Liu L, Yang CY, Meagher JL, Stuckey JA, McEachern D, Przybranowski S, Wang M, Ran X, Aguilar A, Hu Y, Kampf JW, Li X, Zhao T, Li S, Wen B, Sun D, Wang S. Structure-Based Discover of CF53 as a Potent and Orally Bioavailable Bromodomain and extra-Terminal (BET) Bromodomain Inhibitor. J Med Chem. 2018 Jul 26;61(14):6110-6120.  PMID: 30015487.
  12. Chong Q, Hu Y, Zhou B, Fernandez-Salas E, Yang C, Liu L, McEachern D, Przybranowski S, Wang M, Stuckey J, Meagher J, Bai L, Chen Z, Lin M, Yang J, Ziazadeh D, Xu F, Hu J, Huang L, Siwei L, Wen B, Sun D, Wang S. Discovery of QCA570 as an Exceptionally Potent and Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of the Bromodomain and Extra-Terminal (BET) Proteins Capable of Inducing Complete and Durable Tumor Regression. Journal of Medicinal Chemistry. 2018, July 18. [Epub ahead of print] PMID: 30019901
  13. Hens B, Sinko P, Job N, Dean M, Al-Gousous J, Salehi N, Ziff RM, Tsume Y, Bermejo M, Paixao P, Brasseur JG, Yu A, Talattof A, Benninghoff G, Langguth P, Lennernas H, Hasler WL, Marciani L, Dickens J, Shedden K, Sun D, Amidon GE, Amidon GL. Formulation predictive dissolution (fPD) testing to advance oral drug product development: An introduction to the US FDA funded ‘21st century BA/BE’ project. Int J Pharm. 2018 Sep 5;548(1):120-127. PMID: 29944899
  14. Li W, Tanikawa T, Kryczek I, Xia H, Li G, Wu K, Wei S, Zhao L, Vatan L, Wen B, Sun D, Kleer C, Wicha M, Sabel M, Tao K, Wang G, Zou W. Aerobic glycolysis controls myeloid-derived suppressor cells and tumor immunity via a specific CEPBP isoform in triple-negative breast cancer. Cell Metabolism. 2018 Jul 3;28(1):87-103.e6. PMID: 29805099
  15. Luan X, Guan Y, Liu Q, Zhao M, Sun D, Lovell JF, Sun P, Chen H, Fang C. A Tumor Vascular-Targeted Interlocking Trimodal Nanosystem That Induces and Exploits Hypoxia. 2018 May28;5(8):1800034. PMID: 30128230
  16. Tan YS, Sansanaphongpricha K, Xie Y, Donnelly CR, Luo X, Heath BR, Zhao X, Bellile EL, Hu H, Chen H, Polverini PJ, Chen Q, Young S, Carey TE, Nör JE, Ferris RL, Wolf G, Sun D, Lei YL. Mitigating SOX2-potentiated immune escape of head and neck squamous cell carcinoma with a STING-inducing nanosatellite vaccine. Clin Cancer Res. 2018 May 16. [Epub ahead of print] PMID: 29769207
  17. Borkin D, Klossowski S, Pollock J, Miao H, Linhares BM, Kempinska K, Jin Z, Purohit T, Wen B, He M, Sun D, Cierpicki T, Grembecka J. Complexity of blocking bivalent protein-protein interactions: Development of a highly potent inhibitor of the menin-mixed-lineage leukemia interaction. J Med Chem. 2018 May 23. [Epub ahead of print] PMID: 29738674
  18. Madak JT, Cuthbertson CR, Miyata Y, Tamura S, Petrunak EM, Stuckey JA, Han Y, He M, Sun D, Showalter HD, Neamati N. Design, synthesis, and biological evaluation of 4-quinoline carboxylic acids as inhibitors of dihydroorotate dehydrogenase. J Med Chem. 2018 May 14. [Epub ahead of print] PMID: 29727569
  19. Lin C-C, Lo M-C, Moody RR, Stevers NO, Tinsley SL, Sun D. Doxycycline targets aldehyde dehydrogenase-positive breast cancer stem cells. Oncology Reports. 2018 Jun;39(6):3041-3047. PMID: 29620216
  20. Tan YS, Sansanaphongpricha, K, Prince MEP, Sun D, Wolf GT, Lei YL. Engineering vaccines to reprogram immunity against head and neck cancer. J Dent Res. 2018 Jun;97(6):627-634. PMCID: PMC5960883
  21. Zwicker JD, Diaz NA, Guerra AJ, Kirchhoff PD, Wen B, Sun D, Carruthers VB, Larsen SD. Optimization of dipeptidic inhibitors of cathepsin L for improved Tosoplasma gondii selectivity and CNS permeability. Bioorg Med Chem Lett. 2018 Jun 1;28(10):1972-1980. PMCID: PMC5938124
  22. Moody RR, Lo MC, Meagher JL, Lin CC, Stevers NO, Tinsley SL, Jung I, Matvekas A, Stuckey JA, Sun D. Probing the interaction between the histone methyltransferase/deacetylase subunit RBBP4/7 and the transcription factor BCL11A in epeigenetic complexes. J Biol Chem. 2018 Feb 9;293(6):2125-2136. PMID: 29263092.
  23. Ye G, Jiang Y, Yang X, Hu H, Wang B, Sun L, Yang VC, Sun D, Gao W. Smart nanoparticles undergo phase transition for enhanced cellular uptake and subsequent intracellular drug release in a tumor microenvironment. ACS Appl Mater Interfaces. 2018 Jan 10;10(1):278-289. PMID: 29260563
  24. Conner TM, Nikolian VC, Georgoff PE, Pai MP, Alam HB, Sun D, Reed RC, Zhang T. Physiologically based pharmacokinetic modeling of disposition and drug-drug interactions for valproic acid and divalproex. Eur J Pharm Sci. 2018 Jan 1;111:465-481. PMID: 29030176
  25. Georgoff PE, Nikolian VC, Bonham T, Pai MP, Tafatia C, Halaweish I, To K, Watcharotone K, Parameswaran A, Luo R, Sun D, Alam HB. Safety and tolerability of intravenous valproic acid in healthy subjects: A phase I dose-escalation trial. Clin Pharmacokinet. 2018 Feb;57(2):209-219. PMID: 28497259.

2017 Publications

  1. Koenigsknecht MJ, Baker JR, Wen B, Frances A, Zhang H, Yu A, Zhao T, Tsume Y, Pai MP, Bleske BE, Zhang X, Lionberger R, Lee A, Amidon GL, Hasler WL, Sun D. In vivo dissolution and systemic absorption of immediate release ibuprofen in human gastrointestinal tract under fed and fasted conditions. Mol Pharm. 2017 Dec 4;14(12):4295-4304. PMID: 28937221
  2. Hens B, Tsume Y, Bermejo M, Paixao P, Koenigsknecht MJ, Baker JR, Hasler WL, Lionberger R, Fan J, Dickens J, Shedden K, Wen B, Wysocki J, Loebenberg R, Lee A, Frances A, Amidon G, Yu A, Benninghoff G, Salehi N, Talattof A, Sun D, Amidon GL. Low buffer capacity and alternating motility along the human gastrointestinal tract: Implications for in vivo dissolution and absorption of ionizable drugs. Mol Pharm. 2017 Dec 4;14(12):4281-4294. PMID: 28737409
  3. Yu A, Jackson T, Tsume Y, Koenigsknecht M, Wysocki J, Marciani L, Amidon GL, Frances A, Baker JR, Hasler W, Wen B, Pai A, Sun D. Mechanistic fluid transport model to estimate gastrointestinal fluid volume and its dynamic change over time. AAPS J. 2017 Nov;19(6):1682-1690. PMID:28980204
  4. Connarn JN, Flowers S, Kelly M, Luo R, Ward KM, Harrington G, Moncion I, Kamali M, McInnis M, Feng MR, Ellingrod V, Babiskin A, Zhang X, Sun D. Pharmacokinetics and pharmacogenomics of bupropion in three different formulations with difference release kinetics in healthy human volunteers. AAPS J. 2017 Sep;19(5):1513-1522. PMID: 28685396
  5. Kick BL, Shu P, Wen B, Sun D, Taylor DK. Pharmcokinetic profiles of nalbuphine after intraperitoneal and subcutaneous administration to C57BL/6 mice. J Am Assoc Lab Anim Sci. 2017 Sep 1;56(5):534-538. PMCID: PMC5605177
  6. Yu J, Zhang H, Li Y, Sun S, Gao J, Zhong Y, Sun D, Zhang G. Metabolomics revealed the toxicity of cationic liposomes in HepG2 cells using UHPLC-Q-TOF/MS and multivariate data analysis. Biomed Chromotogr. 2017 Dec;31(12). PMID: 28664536
  7. Zhou B, Hu J, Xu F, Chen Z, Bai L, Fernandez-Salas E, Lin M, Liu L, Yang CY, Zhao Y, McEachern D, Przybranowski S, Wen B, Sun D, Wang S. Discovery of a small-molecule degrader of Bromodomain and Extra-Terminal (BET) proteins with picomolar cellular potencies and capable of achieving tumor regression. J Med Chem. 2018 Jan 25;61(2):462-481. PMCID: PMC5788414
  8. Luan X, Sansanaphongpricha K, Myers I, Chen H, Yuan H, Sun D. Engineering exosomes as refined biological nanoplatforms for drug delivery. Acta Pharmacol Sin. 2017 Jun;38(6)754-763. PMCID: PMC5520184
  9. Sun L, Cao J, Guo C, Burnett J, Yang Z, Ran Y, Sun D. Associations of carboxypeptidase 4 with ALDH1A1 expression and their prognostic value in esophageal squamous cell carcinoma. Dis Esophagus. 2017 Jun 1; 30(6):1-5. PMID: 28475748
  10. Sun L, Guo C, Cao J, Burnett J, Yang Z, Ran Y, Sun D. Over-expression of alpha-enolase as a prognostic biomarker in patients with pancreatic cancer. Int J Med Sci. 2017 Jun 22;14(7):655-661. PMCID: 28824297
  11. Karatas H, Li Y, Liu L, Ji J, Lee S, Chen Y, Yang J, Huang L, Bernard D, Xu J, Townsend EC, Cao F, Ran X, Li X, Wen B, Sun D, Stuckey JA, Lei M, Dou Y, Wang S. Discovery of a highly potent, cell-permeable macrocyclic peptidomimetic (MM-589) targeting the WD repeat domain 5 protein (WDR5)–mixed lineage leukemia (MLL) protein-protein interaction. J Med Chem. 2017 Jun 22;60(12):4818-4839. PMID: 28603984
  12. Zhao Y, Bai L, Liu L, McEachern D, Stuckety JA, Meagher JL, Yang CY, Ran X, Zhou B, Hu Y, Li X, Wen B, Zhao T, Li S, Sun D, Wang S. Structure-based discovery of 4-(6-methoxy-2-methyl-4-(quinolin-4-yl)-9H-pyrimido[4,5-b]indol-7-yl)-3,5-dimethylisoxazole (CD161) as a potent and orally bioavailable BET bromodomain inhibitor. J Med Chem. 2017 May 11;60(9):3887-3901. PMID: 28463487
  13. Wang M, Xie F, Wen X, Chen H, Zhang H, Liu J, Zhang H, Zou H, Yu Y, Chen Y, Sun Z, Wang X, Zhang G, Yin C, Sun D, Gao J, Jiang B, Zhong Y, Lu Y. Therapeutic PEG-ceramide nanomicelles synergize with salinomycin to target both liver cancer cells and cancer stem cells. Nanomedicine (Lond). 2017 May;12(9):1025-1042. PMID: 28440698
  14. Tsume Y, Matsui K, Searls AL, Takeuchi S, Amidon GE, Sun D, Amidon GL. The impact of supersaturation level for oral absorption of BCS class IIb drugs, dipyridamole and ketoconazole, using in vivo predictive dissolution system: Gastrointestinal Simulator (GIS). Eur J Pharm Sci. 2017 May 1; 102:126-139. PMID: 28263914
  15. Hutchings KM, Lisabeth EM, Rajeswaran W, Wilson MW, Sorenson RJ, Campbell PL, Ruth JH, Amin A, Tsou PS, Leipprandt JP, Olson SR, Wen B, Zhao T, Sun D, Khanna D, Fox DA, Neubig RR, Larsen SD. Pharmacokinetic optimitzation of CCG-203971: Novel inhibitors of the Rho/MRTF/SRF transcriptional pathway as potential antifibrotic therapeutics for systemic scleroderma. Bioorg Med Chem Lett. 2017 Apr 15;27(8):1744-1749. PMCID: PMC5395305
  16. Aguilar A, Lu J, Liu L, Du D, Bernard D, McEachern D, Przybranowski S, Li X, Luo R, Wen B, Sun D, Wang H, Wen J, Wang G, Zhai Y, Guo M, Yang D, Wang S. Discovery of 4-((3'R,4'S,5'R)-6″-Chloro-4'-(3-chloro-2-fluorophenyl)-1'-ethyl-2″-oxodispiro[cyclohexane-1,2'-pyrrolidine-3',3″-indoline]-5'-carboxamido)bicyclo[2.2.2]octane-1-carboxylic Acid (AA-115/APG-115): A Potent and Orally Active Murine Double Minute 2 (MDM2) Inhibitor in Clinical Development. J Med Chem. 2017 Apr 13;60(7):2819-2839. PMCID: PMC5394527
  17. Patel TS, Cinti S, Sun D, Li S, Luo R, Wen B, Gallagher BA, Stevenson JG. Oseltamivir for pandemic influenza preparation: Maximizing the use of an existing stockpile. Am J Infect Control. 2017 Mar 1;45(3):303-305. PMID: 27816215
  18. Burnett JP, Lim G, Shah RB, Lim R, Paholak HJ, McDermott SP, Sun L, Tsume Y, Bai S, Wicha MS, Sun D, Zhang T. Sulforaphane enhances the anticancer activity of taxanes against triple negative breast cancer by killing cancer stem cells. Cancer Lett. 2017 May 28;394:52-64. PMID: 28254410
  19. Bai L, Zhou B, Yang CY, Ji J, McEachern D, Przybranowski S, Jiang H, Hu J, Xu F, Zhao Y, Liu L, Fernandez-Salas E, Xu J, Dou Y, Wen B, Sun D, Meagher JL, Stuckey J, Hayes DF, Li S, Ellis MJ, Wang S. Targeted degradation of BET proteins in triple-negative breast cancer. Cancer Res. 2017 May 1; 77(9):2476-2487. PMCID: PMC5413378
  20. Sansanaphongpricha K, DeSantis MC, Chen H, Cheng W, Sun K, Wen B, Sun D. Multibuilding block Janus synthesized by seed-mediated self-assembly for enhanced photothermal effects and colored Brownian motion in an optical trap. Small. 2017 Feb;13(6):1603569. PMID: 27873448
  21. Guo H, Luo H, Yuan H, Xia Y, Shu P, Huang X, Lu Y, Liu X, Keller ET, Sun D, Deng J, Zhang J. Litchi seed extracts diminish prostate cancer progression via induction of apoptosis and attenuation of EMT through Akt/GSK-3β signaling. Sci Rep. 2017 Jan 30;7:41656. PMCID: PMC5278538.
  22. Dahl JU, Gray MJ, Bazopoulou D, Beaufay D, Beaufay F, Lempart J, Koenigsknecht MJ, Wang Y, Baker JR, Hasler WL, Young VB, Sun D, Jakob U. The anti-inflammatory drug mesalamine targets bacterial polyphosphate accumulation. Nat Microbiol. 2017 Jan 23;2:16267. PMCID: PMC5514548
  23. Luo R, LI Y, He M, Zhang H, Yuan H, Johnson M, Palmisano M, Zhou S, Sun D. Distinct biodistribution of doxorubicin and the altered dispositions mediated by different liposomal formulations. Int J Pharm. 2017 Jan 4;519(1-2):1-10. PMID: 28063903
  24. Chen D, Xie F, Sun D, Yin C, Gao J, Zhong Y. Nanomedicine-mediated combination drug therapy in tumor. Open Pharmaceutical Science Journal. 2017 Jan;4:1-10. DOI:10.2174/1874844901704010001
  25. Mahran RI, Hagras MM, Sun D, Brenner DE. Bringing curcumin to the clinic in cancer prevention: A review of strategies to enhance bioavailability and efficacy. AAPS J. 2017 Jan;19(1):54-81. PMID: 27783266
  26. Sun L, Guo C, Burnett JP, Pan J, Yang Z, Ran Y, Sun D. Association between expression of Carboxypeptidase 4 and stem cell markers and their clinical significance in liver cancer development. Journal of Cancer. 2017 Jan 1;8(1):111-116. PMCID: PMC5264046

2016 Publications

  1. Connarn JN, Luo R, Windak J, Zhang X, Babiskin A, Kelly M, Harrington G, Ellingrod VL, Kamali M, McInnis M, and Sun D. Identification of non-reported bupropion metabolites in human plasma. Biopharm Drug Disposition. 2016 Dec;37(9):550-560. PMCID: PMC5132048.
  2. Wagner D, Caraballo M, Waldvogel J, Peterson Y, Sun D. In vitro effects of an extracorporeal membrane oxygenation circuit on the sequestration of ϵ-aminocaproic acid. Perfusion. 2017 Apr;32(3):226-229. PMID: 27815558
  3. Sun L, Guo C, Burnett JP, Yang Z, Ran Y, Sun D. Serum carboxypeptidaseA4 levels predict liver metastasis in colorectal carcinoma. Oncotarget. 2016 Nov 29;7(48):78688-78697. PMCID: PMC5346670
  4. Sun L, Guo C, Yuan H, Burnett JP, Pan J, Yang Z, Ran Y, Myers I, Sun D. Overexpression of carboxypeptidase A4 (CPA4) is associated with poor prognosis in patients with gastric cancer. American Journal of Translational Research. 2016 Nov 15;8(11):5071-5075. eCollection 2016. PMCID: PMC5126350
  5. Zhang H, Lauver DA, Wang H, Sun D, Hollenberg PF, Chen YE, Osawa Y, Eitzman DT. Significant improvement of antithrombotic responses to clopidogrel by use of a novel conjugate as revealed in an arterial model of thrombosis. J Pharmacol Exp Ther. 2016 Oct;359(1):11-7. PMCID: PMC5034710
  6. Sun L, Burnett JP, Zou H, Sun D. Overexpression of ALDH1A1 is associated with poor prognosis and therapeutic effects of sulforaphane in esophageal cancer. Int J Clin Exp Pathol. 2016;9(11):11670-11675.
  7. Costa MD, Ashraf NS, Fischer S, Yang Y, Schapka E, Joshi G, McQuade TJ, Dharia RM, Dulchavsky M, Ouyang M, Cook D, Sun D, Larsen MJ, Gestwicki JE, Todi SV, Ivanova MI, Paulson HL. Unbiased screen identifies aripiprazole as a modulator of abundance of the polyglutamine disease protein, ataxin-3. Brain. 2016 Nov 1;139(11):2891-2908. PMCID: PMC5840879
  8. Jia T, Sun Z, Lu Y, Gao J, Zou H, Xie F, Zhang G, Xu H, Sun D, Yu Y, Zhong Y. A dual brain-targeting curcumin-loaded polymersomes ameliorated cognitive dysfunction in intrahippocampal amyloid- β1-42-injected mice. Int J Nanomedicine. 2016 Aug 5;11:3765-75. eCollection 2016. PMCID: PMC4981163
  9. Paholak HJ, Stevers NO, Chen H, Burnett JP, He M, Korkaya H, McDermott SP, Deol Y, Clouthier SG, Luther T, Li Q, Wicha MS, Sun D. Elimination of epithelial-like and mesenchymal-like breast cancer stem cells to inhibit metastasis following nanoparticle-mediated photothermal therapy. Biomaterials. 2016 Oct;104:145-57. PMID: 27450902
  10. Sun L, Wang Y, Yuan H, Burnett JP, Pan J, Yang Z, Ran Y, Myers I, Sun D. CPA4 is a novel diagnostic and prognostic marker for human non-small-cell lung cancer. J Cancer. 2016;7(10):1197-1204. PMCID: PMC4934027
  11. Sun L, Burnett JP, Gasparyan M., Xu F, Jiang H, Lin C-C, Myers I, Korkaya H, Liu Yajing, Connarn J, He H, Zhang N, Wicha MS, Sun D. Novel cancer stem cell targets during epithelial to mesenchymal transition in PTEN-deficient trastuzumab-resistant breast cancer. Oncotarget. 2016 Aug 9;7(32):51408-51422. PMCID: PMC5239484
  12. Passalacqua KD, Charbonneau ME, Donato N, Showalter H, Sun D, Wen B, He M, Sun H, O'Riordan M, Wobu C. Anti-infective activity of 2-cyano-3-acrylamide inhibitors with improved drug-like properties against two intracellular pathogens. American Society for Microbiology. 2016 Jul;60(7):4183-96. PMCID: PMC4914689
  13. Huang J, Tao C, Yu Y, Yu F, Zhang H, Gao J, Wang D, Chen Y, Gao J, Zhang G, Zhou G, Liu J, Sun Z, Sun D, Zou H, Xu H, Lu Y, Zhong Y. Simultaneous targeting of differentiated breast cancer cells and breast cancer stem cells by combination of docetaxel- and sulforaphane-loaded self-assembled poly(D,L-lactide-co-glycolide)/hyaluronic acid block copolymer-based nanoparticles. J Biomed Nanotechnol. 2016 Jul;12(7):1463-77. PMID: 29337484
  14. Ren Y, Wang R, Gao L, Li K, Zhou X, Guo H, Liu C, Han D, Tian J, Ye Q, Hu YT, Sun D, Yuan X, Zhang N. Sequential co-delivery of miR-21 inhibitor followed by burst release doxorubicin using NIR-responsive hollow gold nanoparticle to enhance anticancer efficacy. J Controlled Release. 2016 Apr 28; 228:74-86. PMID: 26956593
  15. Hsu E, Kulp SK, Huang H, Tu H, Chao M, Tseng Y, Yang M, Salunke SB, Sullivan NJ, Chen W, Zhang J, Teng C, Fu W, Sun D, Wicha MS, Shapiro CL, and Chen C. Integrin-linked kinase as a novel molecular switch of the IL-6-NF-κB signaling loop in breast cancer. Carcinogenesis. 2016 Apr;37(4):430-42. PMCID: PMC5006214
  16. Yu F, Huang J, Yu Y, Lu Y, Chen Y, Zhang H, Zhou G, Sun Z, Liu J, Sun D, Zhang G, Zhong Y. Glutathione-Responsive Multilayer Coated Gold Nanoparticles for Targeted Gene Delivery. Journal of Biomedical Nanotechnology. 2016 Mar;12(3):503-15. PMID: 27280248
  17. Borkin D, Pollock JW, Kempinska K, Purohit T, Li X, Wen B, Zhao T, Miao H, Shukla S, He M, Sun D, Cierpicki T, Grembecka J. Property focused structure-based optimization of small molecule inhibitors of the protein-protein interaction between Menin and Mixed Lineage Leukemia (MLL). J Med Chem. 2016 Feb 11;59(3):892-913. PMCID: PMC5092235
  18. Ya-di Yang, Xue-mei Cheng, Wei Liu, Zh-zhen Han, Gui-xin Chou, Ying Wang, Duxin Sun, Zheng-tao Wang, and Chang-hong Wang. Peganumine B-I and two enantiomers: New alkaloids form the seeds of Peganum harmala Linn. and their potential cytotoxicity and cholinesterase inhibitory activities. RSC Advances. 2016;6:15976. DOI:  
  19. Yan Li, Duxin Sun, Maria Palmisano, and Simon Zhou. Slow drug delivery decreased total body clearance and altered bioavailability of immediate- and controlled-release oxycodone formulations. Pharmacology Research and Perspectives. 2016 Jan 22;4(1):e00210. PMCID: PMC4777261

Previous Publications

  1. Lichao Sun, Joseph P. Burnett, ChunGuang Guo, Yibin Xie, Jian Pan, Zhihua Yang, Yuliang Ran, Duxin Sun. CPA4 is a promising diagnostic serum biomarker for pancreatic cancer. Am J Cancer Res. 2015 Dec 15;6(1):91-96. PMCID: PMC4759400
  2. Burnett JP, Korkaya H, Ouzounova MD, Jiang H, Conley SJ, Newman BW, Sun L, Connarn JN, Chen CS, Zhang N, Wicha MS, Sun D. Trastuzumab resistance induces EMT to transform HER2(+) PTEN(-) to a triple negative breast cancer that requires unique treatment options. Sci Rep. 2015;5:15821. PMCID: PMC4629137
  3. Zhang H, Sun S, Chen Q, Zhang G, Zhang Z, Sun D, Zhang W. A screening method for potential anti-pancreatic cancer candidate compounds based on Hsp90-Cdc37 interaction model in vitro. Letters in Drug Design and Discovery. 2015;12(1):66-71.
  4. Hsu E, Kulp SK, Huang H, Tu H, Salunke SB, Sullivan NJ, Sun D., Wicha MS, Shapiro CL, Chen C-S. Function of Integrin-Linked Kinase in Modulating the Stemness of IL-6–Abundant Breast Cancer Cells by Regulating γ-Secretase–Mediated Notch1 Activation in Caveolae. Neoplasia. 2015:17(6):497-508.
  5. Friese, CR, Mendelsohn-Victor K, Wen B, Sun D, Sutcliffe K, Yang JJ, Ronis DL, McCullagh MC, DEFENS Study investigators. DEFENS - Drug Exposure Feedback and Education for Nurses' Safety: study protocol for a randomized controlled trial. Trials. 2015 Apr 17;16:171. PMCID: PMC4411718
  6. Chen H, Ren X, Paholak HJ, Burnett J, Ni F, Fang X, Sun D. Facile fabrication of near-infrared-resonant and magnetic resonance imaging-capable nanomediators for photothermal therapy. ACS Appl Mater Interfaces. 2015 Jun 17;7(23):12814-23. PMID: 26010660
  7. Connarn JN, Zhang X, Babiskin A, Sun D. Metabolism of bupropion by carbonyl reductases in liver and intestine. Drug Metabolism and Disposition. 2015 Jul;43(7):1019-27. PMID: 25904761.
  8. Peterson LF, Sun H, Liu Y, Potu H, Kandarpa M, Ermann M, Courtney SM, Young M, Showalter HD, Sun D, Jakubowiak A, Malek SN, Talpaz M, Donato NJ. Targeting deubiquitinase activity with a novel small molecule inhibitor as therapy for B-cell malignancies. Blood. 2015 Jun 4;125(23):3588-97. PMID: 25814533.
  9. Borkin D, He S, Miao H, Kempinska K, Pollock J, Chase J, Purohit T, Malik B, Zhao T, Wang J, Wen B, Zong H, Jones M, Danet-Desnoyers G, Guzman ML, Talpaz M, Bixby DL, Sun D, Hess JL, Muntean AG, Maillard I, Cierpicki T, Grembecka J. Pharmacologic inhibition of the menin-MLL interaction blocks progression of MLL leukemia in vivo. Cancer Cell. 2015 Apr 13;27(4):589-602. PMCID: PMC4415852
  10. Wang Y, Liu Y, Liu Y, Zhou W, Wang H, Wan G, Sun D, Zhang N, Wang Y. A polymeric prodrug of cisplatin based on pullulan for the targeted therapy against hepatocellular carcinoma. International journal of pharmaceutics. 2015 Apr 10;483(1-2):89-100. PubMed PMID: 25681730.
  11. Wang Y, Yue D, Xiao M, Qi C, Chen Y, Sun D, Zhang N, Chen R. C1QBP Negatively Regulates the Activation of Oncoprotein YBX1 in the Renal Cell Carcinoma as Revealed by Interactomics Analysis. J Proteome Res. 2015 Feb 6;14(2):804-13. PubMed PMID: 25497084.
  12. Friese CR, McArdle C, Zhao T, Sun D, Spasojevic I, Polovich M, McCullagh MC. Antineoplastic Drug Exposure in an Ambulatory Setting: A Pilot Study. Cancer Nurs. 2015;38(2):111-7. PMCID: PMC4232489
  13. Kintzel PE, Zhao T, Wen B, Sun D. Stability of I.V. admixture containing metoclopramide, diphenhydramine hydrochloride, and dexamethasone sodium phosphate in 0.9% sodium chloride injection. Am J Health Syst Pharm. 2014 Dec, 71(23):2061-5.
  14. Chen J, Jiang C, Levant B, Li X, Zhao T, Wen B, Luo R, Sun D, Wang S. Pramipexole derivatives as potent and selective dopamine D3 receptor agonists with improved human microsomal stability. ChemMedChem. 2014 Dec, 9(12):2653-2660.
  15. Liu Y, Wang Y, Zhang C, Zhou P, Liu Y, An T, Sun D, Zhang N, Wang Y. Core-shell nanoparticles based on pullulan and poly(β-amino) ester for hepatoma-targeted codelivery of gene and chemotherapy agent. ACS Applied Materials & Interfaces. 2014 Nov, 6(21): 18712-18720.
  16. Ren X, Chen H, Yang, V, Sun D. Iron oxide nanoparticle-based theranostics for cancer imaging and therapy. Frontiers of Chemical Science and Engineering. 2014 Sept, 8(3): 253-264.
  17. Chen H, Zou H, Paholak HJ, Ito M, Qian W, Che Y, Sun D. Thiol-reactive amphiphilic block copolymer for coating gold nanoparticles with neutral and functionable surfaces. Polym Chem. 2014 Apr 21;5(8):2768-2773. PMID: 24729795
  18. MJ Larsen, SD Larsen, A. Fribley, J. Grembecka, K. Homan, A. Mapp, Z. Nikolovska-Koleska, JA Stuckey, D. Sun, DH Sherman.  The Role of HTS in Drug Discovery at the University of Michigan.  Comb Chem High Throughput Screen. 2014 Mar, 17: 210
  19. Peng Zou, Duxin Sun, PLGA/liposome hybrid nanoparticles for short-chain ceramide delivery. Pharm Res, 2014 Mar, 31: 684.
  20. Abulwerdi, F., Liao, C., Liu, M., Azmi, A.S., Aboukameel, A., Mady, A.S., Gulappa, T., Cierpicki, T., Owens, S., Zhang, T., Sun, D., Stuckey, J.A., Mohammad, R.M., Nikolovska-Coleska, Z. A novel small-molecule inhibitor of Mcl-1 blocks pancreatic cancer growth in vitro and in vivo. Mol Cancer Ther, 2014 Mar, 13: 565
  21. Mancang Gu, Yanke Yu, G. M. Kamal B. Gunaherath, A. A. Leslie Gunatilaka, Dapeng Li, Duxin Sun. Structure-activity relationship (SAR) of withanolides to inhibit Hsp90 for its activity in pancreatic cancer cells. Invest New Drugs, 2014 Feb, 7. DOI 10.1007/s10637-013-9987-y.
  22. Hongwei Chen, Joseph Burnett, Fuxiang Zhang, Jiaming Zhang, Hayley Paholak, and Duxin Sun. Highly crystallized iron oxide nanoparticles as effective and biodegradable mediators for photothermal cancer therapy. J. Mater. Chem. B, 2014, 2(7): 757-765.
  23. Jamie N. Connarn, Victoria A. Assimon, Rebecca A. Reed, Eric Tse, Daniel R. Southworth, Erik R. P. Zuiderweg, Jason E. Gestwicki, Duxin Sun. The Molecular Chaperone Hsp70 Activates Protein Phosphatase 5 (PP5) By Binding the Tetratricopeptide Repeat (TPR) Domain. J Biol Chem, 2014 Jan, 289: 2908
  24. Huang J, Zhang H, Yu Y, Chen Y, Wang D, Zhang G, Zhou G, Liu J, Sun Z, Sun D, Lu Y, Zhong Y. Biodegradable self-assembled nanoparticles of poly (D,L-lactide-co-glycolide)/hyaluronic acid block copolymers for target delivery of docetaxel to breast cancer. Biomaterials. 2014 Jan; 35(1):550-66. doi:10.1016/j.biomaterials.2013.09.089.
  25. L. Lin, B. Hutzen, HF Lee, Z. Peng, W. Wang, C. Zhao, HJ Lin, D. Sun, PK Li, C. Li, H. Korkaya, MS Wicha, J Lin, Evaluation of STAT3 Signaling in ALDH+ and ALDH+/CD44+/CD24-Subpopulations of Breast Cancer Cells, PLoS One, 2013, Dec. 23; 8 (12):e82821.
  26. Li X, Srinivasan SR, Connarn J, Ahmad A, Young ZT, Kabza AM, Zuiderweg ER, Sun D, Gestwicki JE. Analogs of the Allosteric Heat Shock Protein 70 (Hsp70) Inhibitor, MKT-077, as Anti-Cancer Agents. ACS Med Chem Lett. 2013 Nov 14;4(11). doi: 10.1021/ml400204n.
  27. Chen SL, Burnett J, Sun D, Wei X, Xie Z, Wang X. Photoacoustic microscopy: a potential new tool for evaluation of angiogenesis inhibitor. Biomed Opt Express. 2013 Oct 25;4(11):2657-66.
  28. Zou, P., Chen, H., Paholak, H.J., Sun, D., Noninvasive fluorescence resonance energy transfer imaging of in vivo premature drug release from polymeric nanoparticles, Mol Pharm, 2013 Nov, 10: 4185
  29. Zeller, J., Turbiak, A.J., Powelson, I.A., Lee, S., Sun, D., Showalter, H.D., Fearon, E.R., Investigation of 3-aryl-pyrimido[5,4-e][1,2,4]triazine-5,7-diones as small molecule antagonists of ᵦ-catenin/TCF transcription, Bioorg Med Chem Lett. 2013 Nov, 23: 5814
  30. Hongwei Chen, Hayley Paholak, Masayuki Ito,  Kanokwan Sansanaphongpricha, Wei Qian, Yong Che, Duxin Sun. Living PEGylation on gold nanoparticles to optimize cancer cell uptake by controlling targeting ligand and charge densities. Nanotechnology, 2013, 24(35):355101.
  31. Yanyan Li, Tao Zhang, Xiaoqin Li, Peng Zou, Katlyn M. Soriano, Steven J. Schwartz, Duxin Sun. Kinetics of Sulforaphane in Mice after Consumption of Sulforaphane-Enriched Broccoli Sprout Preparation. Molecular Nutrition & Food Research, 2013 Dec, 57(12):2128-36. PMCID: PMC3855579
  32. Wang D, Huang J, Wang X, Yu Y, Zhang H, Chen Y, Liu J, Sun Z, Zou H, Sun D, Zhou G, Zhang G, Lu Y, Zhong Y. The eradication of breast cancer cells and stem cells by 8-hydroxyquinoline-loaded hyaluronan modified mesoporous silica nanoparticle-supported lipid bilayers containing docetaxel. Biomaterials. 2013 Oct, 34(31):7662-73.
  33. Tao Zhang, Yanyan Li, Peng Zou, Jing-yu Yu, Donna McEachern, Shaomeng Wang, and Duxin Sun. Physiologically based pharmacokinetic and pharmacodynamics modeling of an antagonist (SM-406/AT-406) of multiple inhibitor of apoptosis proteins (IAPs) in a mouse xenograft model of human breast cancer. Biopharmaceutics & Drug Disposition, 2013, 34:348-59. PMID: 23813446
  34. Peng Zou, Hong-Wei Chen, Hayley J Paholak, Duxin Sun. Burst Release of Lipophilic Drugs from Poly (Ethylene Oxide)-B-Polystyrene Micelles is not Caused by Micelle Disassembly. J of Tumor, 2013, 1 (2): 7.
  35. Zhao Y, Yu S, Sun W, Liu L, Lu J, McEachern D, Shargary S, Bernard D, Li X, Zhao T, Zou P, Sun D, Wang S. A Potent Small-Molecule Inhibitor of the MDM2-p53 Interaction (MI-888) Achieved Complete and Durable Tumor Regression in Mice. J Med Chem. 2013, 56 (13):5553–61.
  36. Y Zhao, W Sun, J Lu, D McEachern, X Li, S Yu, D Bernard, P. Ochsenbein, P, V Ferey, JC Carry, JR Deschamps, D Sun, S. Wang, Diasteremoeric spirooxindoles as highly potent and efficacious MDM2, J Am Chem Soc, 2013, May 15; 135 (19):7223-34.
  37. Y. Miyata, X. Li, U.K. Jinwal, S.R. Srinivasan, S.P. Sequin, Z.T. Young, J.L. Bodsky, C.A. Dickey, D. Sun, J.E. Gestwicki, Synthesis and initial evaluation of YM-08, a blood-brain barrier permeable derivative of the heat shock protein 70 (Hsp70) inhibitor MKT-077, which reduces tau levels. ACS Chem Neurosci, 2013, 4(6):930–9 .(2012 IF: 3.676)
  38. G. Zhou, Y. Lu, H. Zhang, Y. Chen, Y. Yu, J. Gao, D. Sun, G. Zhang, H. Zou, Y. Zhong. A novel pulsed drug-delivery system: polyelectrolyte layer-by-layer coating of chitosan-alginate microgels., Int. J. Nanomedicine, 2013; 8:877-87.
  39. Bryan D. Yestrepskya, Yuanxi Xuc, 1, Meghan E. Breena, Xiaoqin Li, Walajapet G. Rajeswarana, Jenny G. Ryua, Roderick J. Sorensona, Yasuhiro Tsume, Michael W. Wilsona, Wenpeng Zhang, Duxin Sun, Hongmin Sunc, Scott D. Larsen. Novel Inhibitors of Bacterial Virulence: Development of 5,6-dihydrobenzo[h]quinazolin-4(3H)-ones for the Inhibition of Group A Streptococcal Streptokinase Expression. Bioorganic & Medicinal Chemistry, Biorg Med Chem, 2013 Apr 1; 21(7):1880-97.
  40. Hongwei Chen, Peng Zou, Jamie Connarn, Hayley Paholak, Duxin Sun. Intracellular dissociation of a polymer coating from nanoparticles. Nano Research, 2012, 5: 815-825
  41. Bryan Newman, Yan Liu, Hsiu-Fang Lee, Duxin Sun, Yin Wang. HSP90 inhibitor 17-AAG selectively eradicates lymphoma stem cells. Cancer Research, 2012: 72(17):4551-61 (*co-corresponding authors)
  42. Peng Zou, Nan Zheng, Yongsheng Yang, Lawrence X Yu, Duxin Sun. Prediction of Volume of Distribution at Steady-State in Humans: Comparison of Different Approaches. Expert Opinion on Drug Metabolism and Toxicology, 2012, 8: 855-72.
  43. Peng Zou, Nan Zheng, Yanke Yu, Shanghai Yu, Wei Sun, Donna McEachern, Yongsheng Yang, Lawrence X. Yu, Shaomeng Wang, Duxin Sun. Preclinical pharmacokinetics of MI-219, a novel human double minute 2 (HDM2) inhibitor and prediction of human pharmacokinetics. J Pharmacy Pharmaceutics Sciences, 2012, 15: 265-80
  44. Joseph Burnett, Bryan Newman, Duxin Sun. Targeting Cancer Stem Cells with Natural Products. Current Drug Targets, 2012, 13: 1054-64.
  45. Yu S, Zhang G, Zhang W, Luo H, Qiu L, Liu Q, Sun D, Wang PG, Wang F. Synthesis and biological activities of a 3'-azido analogue of Doxorubicin against drug-resistant cancer cells. Int J Mol Sci. 2012;13: 3671-84.
  46. Li Y, Karagöz GE, Seo YH, Zhang T, Jiang Y, Yu Y, Duarte AM, Schwartz SJ, Boelens R, Carroll K, Rüdiger SG, Sun D. Sulforaphane inhibits pancreatic cancer through disrupting Hsp90-p50(Cdc37) complex and direct interactions with amino acids residues of Hsp90. J Nutr Biochem. 2012, 23: 1617-26.
  47. Zou P, Yu Y, Zheng N, Yang Y, Paholak HJ, Yu LX, Sun D. Applications of Human Pharmacokinetic Prediction in First-in-Human Dose Estimation. AAPS J. 2012; 14: 262-81.
  48. Li Y, Zhang T, Schwartz SJ, Sun D. Sulforaphane potentiates the efficacy of 17-allylamino 17-demethoxygeldanamycin against pancreatic cancer through enhanced abrogation of Hsp90 chaperone function. Nutr Cancer. 2011, 63(7):1151-9.
  49.  Yu Y, Zick S, Li X, Zou P, Wright B, Sun D. Examination of the pharmacokinetics of active ingredients of ginger in humans. AAPS J. 2011, 13(3):417-26.
  50. Sun H, Liu L, Lu J, Bai L, Li X, Nikolovska-Coleska Z, McEachern D, Yang CY, Qiu S, Yi H, Sun D, Wang S. Potent Bivalent Smac Mimetics: Effect of the Linker on Binding to Inhibitor of Apoptosis Proteins (IAPs) and Anticancer Activity. J Med Chem. 2011, 54: 3306-18.
  51. Cai Q, Sun H, Peng Y, Lu J, Nikolovska-Coleska Z, McEachern D, Liu L, Qiu S, Yang CY, Miller R, Yi H, Zhang T, Sun D, Kang S, Guo M, Leopold L, Yang D, Wang S. A Potent and Orally Active Antagonist (SM-406/AT-406) of Multiple Inhibitor of Apoptosis Proteins (IAPs) in Clinical Development for Cancer Treatment. J Med Chem. 2011, 54:2714-26.
  52. Li Y, Wicha MS, Schwartz SJ, Sun D. Implications of cancer stem cell theory for cancer chemoprevention by natural dietary compounds. J Nutr Biochem. 2011, 22: 799-806.
  53. Zheng N, Zou P, Wang S, Sun D. In Vitro Metabolism of 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin (17-DMAG) in Human Liver Microsomes. Drug Metab Dispos. 2011, 39:627-35.
  54. Sun D. Nanotheranostics: integration of imaging and targeted drug delivery. Mol Pharm. 2010, 7:1879.
  55. Zou P, Yu Y, Wang YA, Zhong Y, Welton AR, Galbán C, Wang S, Sun D. Superparamagnetic iron oxide "nanotheranostics" for targeted cancer cell imaging and pH-dependent intracellular drug release. Mol Pharm. 20107: 1974-84.
  56. Zou P, Povoski SP, Hall NC, Carlton MM, Hinkle GH, Xu RX, Mojzisik CM, Johnson MA, Knopp MV, Martin EW Jr, Sun D. 124I-HuCC49deltaCH2 for TAG-72 antigen-directed positron emission tomography (PET) imaging of LS174T colon adenocarcinoma tumor implants in xenograft mice: preliminary results. World J Surg Oncol. 2010; 8:65.
  57. Zhang T, Li Y, Zhu Z, Gu M, Newman B, Sun D. MEK Inhibition Potentiates the Activity of Hsp90 Inhibitor 17-AAG against Pancreatic Cancer Cells. Mol Pharm. 2010, 7: 1576-84.
  58. Liu Q, Zhang H, Zhou G, Xie S, Zou H, Yu Y, Li G, Sun D, Zhang G, Lu Y, Zhong Y. In vitro and in vivo study of thymosin alpha1 biodegradable in situ forming poly(lactide-co-glycolide) implants. Int J Pharm. 2010397(1-2):122-9.
  59. Zhu Z, Xu X, Yu Y, Graham M, Liu G, Prince ME, Carey TE, Sun D. Silencing Heat Shock Protein 27 (Hsp27) decreases metastatic behavior of human head and neck squamous cell cancer cells in vitro. Mol Pharm, 2010, 7(4):1283-90.
  60. Yiqun Jiang, Denzil Bernard, Yanke Yu, Yehua Xie, Tao Zhang, Yanyan Li, Joseph Burnett, Xueqi Fu, Shaomeng Wang, and Duxin Sun. Split Renilla Luciferase Protein-Fragment-Assisted Complementation (SRL-PFAC) to Characterize Hsp90/Cdc37 Complex and Identify Critical Residues in Protein-Protein Interactions. J Biol Chem, 2010, 285:21023-36.
  61. Yanyan Li, Tao Zhang, Hasan Korkaya, Suling Liu, Yanke Yu, Hsiu-Fang Lee, Bryan Newman, Shawn G. Clouthier, Steven J. Schwartz, Max S. Wicha, and Duxin Sun. Sulforaphane, a Dietary Component of Broccoli/Broccoli Sprouts, Inhibits Breast Cancer Stem Cells. Clinical Cancer Research, 2010,16: 2580-90.
  62. Yanke Yu, Adel Hamza, Tao Zhang, Mancang Gu, Peng Zou, Bryan Newman, Yanyan Li, A. A. Leslie Gunatilaka, Chang-Guo Zhan, and Duxin Sun. Withaferin A Targets Heat Shock Protein 90 in Pancreatic Cancer Cells. Biochemical Pharmacol, 2010, 79: 542-51.
  63. Yanke Yu, Lanyan Fang, Duxin Sun. Biodistribution of HuCC49∆CH2-β-galactosidase in colorectal cancer xenograft model. International J Pharmaceutics, 2010, 386: 208-15.
  64. Yanke Yu and Duxin Sun. Superparamagnetic Iron Oxide nanoparticle (SPIO) “theranostics” for multimodality tumor imaging, gene delivery, targeted drug and prodrug delivery. Expert Review of Clinical Pharmacology, 2010, 3:117-30.
  65. Tao Zhang, Yanyan Li, Yiqun Jiang, Duxin Sun. Characterization of celastrol to inhibit Hsp90 and Cdc37 interaction. J Biol Chem, 2009, 284: 35381-9.
  66. Ho-Chul Shin, Hye-Ryoung Kim, Hee-Jung Cho, Hee Yi, Soo-Min Cho, Dong-Goo Lee, A. M. Abd El-Aty, Jin-Suk Kim, Duxin Sun and Gordon L . Amidon. Comparative Gene Expression of Intestinal Metabolizing Enzymes. Biopharm Drug Dispos, 2009, 30: 411-21.
  67. Yanyan Li, Tao Zhang, Yiqun Jiang, Hsiu-Fang Lee, Stephen J. Schwartz, Duxin Sun. Epigallocatechin-3-gallate Inhibits Hsp90 Function by Impairing Hsp90 Association with Co-chaperones in Pancreatic Cancer Cell Line Mia Paca-2. Molecular Pharmaceutics, 2009, 6, 1152-9.
  68. Yanyan Li, Tao Zhang, Stephen J. Schwartz, Duxin Sun. New developments in Hsp90 inhibitors as anti-cancer therapeutics: mechanisms, clinical perspective and more potential. Drug Resistance Updates, 2009, 12: 17-27.
  69. Peng Zou, Songbo Xu, Stephen P Povoski, Anna Wang, Morgan A. Johnson, Edward W. Martin,Jr. Vish Subramaniam, Ronald Xu, Duxin Sun. Near-Infrared Fluorescence Labeled Anti-TAG-72 Monoclonal Antibodies for Tumor Imaging in Colorectal Cancer Xenograft Mice. Molecular Pharmaceutics, 2009, 6, 428-40.
  70. Ronald X. Xu, Jiwei Huang, Jeff S. Xu, Duxin Sun, George H. Hinkle, Edward W. Martin, Jr., Stephen P. Povoski. Fabrication of indocyanine green encapsulated biodegradable microbubbles for structural and functional imaging of cancer. Journal of Biomedical Optics, 2009, 14, 034020.
  71. Jie Shen, Robert Woodward, James Patrick Kedenburg, Xianwei Liu, Min Chen, Lanyan Fang, Duxin Sun, Peng George Wang. Histone Deacetylase Inhibitors through Click Chemistry. Journal of Medicinal Chemistry, 2008, 51: 7417-27.
  72. Dongfeng Yin, Ying Lu, He Zhang, Guoqing Zhang, Hao Zou, Duxin Sun, Yanqiang Zhong. Preparation of glucagon-like peptide-1 loaded PLGA microspheres: characterizations, release studies and bioactivities in vitro/in vivo. Chemical & Pharmaceutical Bulletin, 2008, 56: 156-61.
  73. He Zhang, Ying Lu, Guoqing Zhang, Shen Gao, Duxin Sun, Yanqiang Zhong. Bupivacaine-loaded biodegradable poly(lactic-co-glycolic) acid microspheres: I. Optimization of the drug incorporation into the polymer matrix and modelling of drug release. International Journal of Pharmaceutics, 2008, 351, 244-9.
  74. Bei Wang, Stephen P Povoski, Xianhua Cao, Duxin Sun, Ronald X. Xu. Dynamic schema for near infrared detection of pressure-induced changes in solid tumors. Applied Optics, 2008, 47: 3053-63.
  75. Lanyan Fang, Duxin Sun. Predictive physiologically based pharmacokinetic model for antibody-directed enzyme prodrug therapy. Drug Metabolism and Disposition, 2008, 36: 1153-65.
  76. Tao Zhang, Adel Hamza, Xianhua Cao, Bing Wang, Shuwen Yu, Chang-Guo Zhan, Duxin Sun. A Novel Hsp90 inhibitor disrupts Hsp90-Cdc37 complex for pancreatic cancer therapy. Molecular Cancer Therapeutics, 2008, 7: 162-70.
  77. Xianhua Cao, Mark Bloomston, Guang Jia, Wendy L. Frankel, Tao Zhang, Nathan Hall, Hao Cheng, Michael Knopp, and Duxin Sun. Simultaneously Targeting Hypoxic Cancer Cells by HSP90 Inhibitor and Glycolysis Inhibitor in Pancreatic Cancer Therapy. Clinical Cancer Research, 2008; 14: 1831-9.
  78. Xianhua Cao, Bing Wang, Guang Jia, Ming Yang, Michael V. Knopp and Duxin Sun. Non-invasive tumor MRI imaging and synergistic anti-tumor effect of HSP90 inhibitor and glycolysis inhibitor in RIP1-Tag2 transgenic pancreatic tumor model. Cancer Chemotherapy and Pharmacology, 200862: 985-94.
  79. Huifei Cui, Jie Shen, Dongning Lu, Tao Zhang, Wenpeng Zhang, Duxin Sun, Peng George Wang. 4-Aryl-1,3,2-oxathiazolylium-5-olate: A novel GST Inhibitor to release JNK and activate c-Jun for cancer therapy. Cancer Chemotherapy and Pharmacology, 2008, 62: 509-15.
  80. Polli JE, Abrahamsson BS, Yu LX, Amidon GL, Baldoni JM, Cook JA, Fackler P, Hartauer K, Johnston G, Krill SL, Lipper RA, Malick WA, Shah VP, Sun D, Winkle HN, Wu Y, Zhang H. Summary workshop report: bioequivalence, biopharmaceutics classification system, and beyond. AAPS J, 2008, 10:373-9.
  81. Ying Lu, Guoqing Zhang, Duxin Sun, Yanqiang Zhong. Preparation and evaluation of biodegradable flurbiprofen gelatin microspheres for intra-articular administration.  Journal of Microencapsulation, 2007, 24, 515
  82. Duxin Sun, Mark Bloomston, George Hinkle, Osama Habib Al-Saif, Nathan C. Hall, Stephen P. Povoski, Mark W. Arnold, Edward W. Martin Jr. Radioimmunoguided Surgery (RIGS), PET/CT Image-Guided Surgery, and Fluorescence Image-Guided Surgery: Past, Present, and Future. Journal Surgical Oncology, 200796: 297.
  83. Robert Battisti, Yanqiang Zhong, Lanyan Fang, Seth Gibbs, Jie Shen, Janos Nadas, Guisheng Zhang, Duxin Sun. Modifying the Sugar Moieties of Anthracyclines Overcomes P-gp-Mediated Multidrug Resistance. Mol Pharm 2007, 4: 140
  84. Lanyan Fang, Nicholas H. G. Holford, George Hinkle, Xianhua Cao, Mark P. Bloomston, Jim J Xiao, Seth Gibbs, Osama Habib Al Saif, James T. Dalton, Kenneth K. Chan, Jeffrey Schlom,  Edward Martin, and Duxin Sun. Population Pharmacokinetics of Humanized Monoclonal Antibody HuCC49∆CH2 and Murine Antibody CC49 in Colorectal Cancer Patients. J Clin Pharmacol 2007 47: 227
  85. Cao X, Fang L, Gibbs S, Huang Y, Dai Z, Wen P, Zheng X, Sadee W, Sun D. Glucose uptake inhibitor sensitizes cancer cells to daunorubicin and overcomes drug resistance in hypoxia. Cancer Chemotherapy and Pharmacology, 200759: 495-505
  86. Hye-Ryoung Kim, Sung-Won Park, Hee-Jung Choa, Kyung-Ae Chaea, Ji-Min Sunga, Jin-Suk Kima, Christopher P. Landowski, Duxin Sun, A.M. Abd El-Aty, Gordon L. Amidon, Ho-Chul Shin. Comparative gene expression profiles of intestinal transporters in mice, rats and humans. Pharmacological Research, 2007, 56: 224-236
  87. Lanyan Fang, Guisheng Zhang, Chenglong Li, Xincheng Zheng, Lizhi Zhu, Jim J. Xiao, Gergely Szakacs, Janos Nadas, Kenneth K. Chan, Peng George Wang, and Duxin Sun. Discovery of a Daunorubicin Analogue That Exhibits Potent Antitumor Activity and Overcomes P-gp-Mediated Drug Resistance. J Med Chem, 2006; 49: 932-941
  88. Sherif I. Farag Badawy, David B. Gray, Fang Zhao, Duxin Sun, Alan E. Schuster, Munir A. Hussain Formulation of Solid Dosage Forms to Overcome Gastric pH Interaction of the Factor Xa Inhibitor, BMS-561389. Pharm Res, 2006, 23, 989
  89. Guisheng Zhang, Lanyan Fang, Lizhi Zhu, Yanqiang Zhong, George P. Wang, Duxin Sun. Syntheses and Biological Activities of 3’-Azido Disaccharide Daunorubicins against drug-resistant leukemia, J Med Chem, 2006 49(5); 1792-1799
  90. Janos Nadas and Duxin Sun. Anthracyclines as effective anticancer drugs. Expert Opinion on Drug Discovery, 20061: 549
  91. Xianhua Cao, Seth T. Gibbs, Lanyan Fang, Heather A. Miller, Christopher P. Landowski, Ho-Chul Shin, Hans Lennernas, Yanqiang Zhong, Gordon L. Amidon, Lawrence X. Yu, and Duxin Sun. Why is it Challenging to Predict Intestinal Drug Absorption and Oral Bioavailability in Human Using Rat Model. Pharm Res, 2006, 23: 1675
  92. Guisheng Zhang, Lanyan Fang, Lizhi Zhu, Duxin Sun, and Peng George Wang. Syntheses and Biological activities of Bisdaunorubicins. Bioorganic and Medicinal Chemistry, 2006, 14: 426-434
  93. Lanyan Fang, Robert F. Battisti, Hao Cheng, Philip Reigan, Yan Xin, Jie Shen, David Ross, Kenneth K. Chan, Edward W. Martin Jr, Peng George Wang, and Duxin Sun. Enzyme Specific Activation of Benzoquinone Ansamycin Prodrugs Using Humanized HuCC49CH2-alpha-Galactosidase Conjugates. J Med Chem, 2006, 49: 6290. PMCID: PMC2596603
  94. Rong Zhou, Paul Moench, Christopher Heran, Xujin Lu, Neil Mathias, Teresa Faria, Doris A. Wall, Munir A. Hussain, Ronald L. Smith, and Duxin Sun. pH-Dependent Dissolution In Vitro and Absorption In Vivo of Weakly Basic Drugs: Development of a Canine Model. Pharmaceutical Research, 2005, 22: 188
  95. Jim Xiao, Sara Horst, George Hinkle, Xianhua Cao, Ergun Kocak, Jing Fang, Donn Young, M. Khazaeli, Doreen Agnese, Duxin Sun, and Edward Martin, Jr. Pharmacokinetics and Clinical Evaluation of 125I-Radiolabeled Humanized CC49 Monoclonal Antibody (HuCC49deltaCH2) in Recurrent and Metastatic Colorectal Cancer Patients. Cancer Biotherapy and Radiopharmaceuticals, 2005, 20; 16
  96. Hao Cheng, Xianhua Cao, Ming Xian, Lanyan Fang, Tingwei Bill Cai, Jacqueline Jia Ji, Josefino B. Tunac, Duxin Sun, and Peng George Wang. Synthesis and Enzyme-Specific Activation of Carbohydrate-Geldanamycin Conjugates with Potent Anticancer Activity. J Med Chem, 2005, 48: 645
  97. Guisheng Zhang, Jie Shen, Hao Cheng, Lizhi Zhu, Lanyan Fang, Sanzhong Luo, Mark T. Muller, Gun Eui Lee,| Lijun Wei, Yuguo Du, Duxin Sun, and Peng George Wang. Syntheses and Biological Activities of Rebeccamycin Analogues with Uncommon Sugars. Journal of Medicinal Chemistry, 2005, 48(7); 2600-261
  98. Guisheng Zhang, Lanyan Fang, Lizhi Zhu, Josephine E. Aimiuwu, Jie Shen, Hao Cheng, Mark T. Muller, Gun Eui Lee, Duxin Sun, and Peng George Wang. Syntheses and Biological Activities of Disaccharide Daunorubicins. Journal of Medicinal Chemistry, 2005, 48, 5269-78
  99. Xianhua Cao, Lawrence X. Yu, Catalin Barbaciru, Christopher P. Landowski, Ho-Chul Shin, Seth Gibbs, Heather A. Miller, Gordon L. Amidon, and Duxin Sun. Permeability Dominates in Vivo Intestinal Absorption of P-gp Substrate with High Solubility and High Permeability. Molecular Pharmaceutics, 2005, 2; 329-340
  100. Lizhi Zhu, Xianhua Cao, Wenlan Chen, Guisheng Zhang, Duxin Sun, Peng George Wang. Syntheses and Biological Activities of Daunomycin Analogs with Uncommon Sugars. Bioorganic and Medicinal Chemistry, 2005, 13: 6381-6387
  101. Sun D, Yu LX, M. Hussain, RL Smith, Amidon GL, and Smith RL. In vitro testing of drug absorption for drug “developability” assessment: Forming an interface between in vitro preclinical data and clinical outcome. Current Opinion in Drug Discovery and Development 2004, 7 (1); 75-85
  102. Landowski CP, Anderle P, Sun D, Sadee W, Amidon GL. Transporter and Ion Channel Gene Expression After Caco-2 Cell Differentiation Using 2 Different Microarray Technologies. AAPS Pharmasci. 2004; 6 (3): art 21.
  103. CP Landowski, D Sun, DR Foster, SS Menon, JL Barnett, LS Welage, C Ramachandra, GL Amidon. Gene expression in the human intestine and correlation with oral valacylovir pharmacokinetic parameters. J Pharmacol Exp Ther, 2003, 306: 778-86.
  104. Shin HC, Landowski CP, Sun D, Vig BS, Kim I, Mittal S, Lane M, Rosania G, Drach JC, and Amidon GL. Functional expression and characterization of a sodium-dependent nucleoside transporter hCNT2 cloned from human duodenum. Biochem Biophys Res Commun 2003, 307: 696-703.
  105. Walters CL, Wang BC, Godfrey M, Sun D, Funk CD, and Blendy JA. Augmented response to morphine and cocaine in mice with a mutation in the 12-lipoxygenase gene. Psychopharmacol 2003, 170:124-31
  106. Qi X, Ackermann C, Sun D, Sheng Minli, Hou H. Physichochemical characterization and percutaneous delivery of 2,3,5,6-tetramethylpyrazine. Int J Pharmaceutics 2003, 253: 177-183.
  107. Qi X, Liu R, Sun D, Ackermann C, Hou H. Convolution method to predict drug concentration profiles of 2,3,5,6-tetramethylpyrazine following transdermal application. Int J Pharmaceutics 2003, 259: 39-45
  108. Sun D, Lennernas H, Welage LS, Barnett JL, Landowski CP, Foster D, Fleisher D, Lee KD and Amidon GL. Comparison of human duodenum and Caco-2 gene expression profiles for 12,000 gene sequence tags and correlation with permeability of 26 drugs. Pharm. Res. 2002, 19: 1400-16.
  109. Qi X, Ackermann C, Sun D, Liu R, Sheng M, and Hou H. The prediction of plasma and brain levels of 2,3,5,6-tetramethylpyrazine following transdermal applications. AAPS Pharmasci 2002, 4(4): 46.
  110. Sun D, Landowski C, Chu X, Wallsten R, Komorowski TE, Fleisher D, and Amidon GL. Drug inhibition of Gly-Sar uptake and hPepT1 localization using hPepT1-GFP fusion protein. AAPS Pharmasci  2001, 3: E2.
  111. Bleich D, Chen S, Zipser B, Sun D, Funk CD, Nadler JL. Resistance to type 1 diabetes induction in 12-lipoxygenase knockout mice. J Clinical Investigation 1999, 103: 1431.
  112. Johnson EN, Sun D, Chen XS, and Funk CD. Lipoxygenase gene disruption studies. Status and applications. Advances in Experimental Medicine & Biology 1999, 447:63-73.
  113. Sun D, McDonnell M, Chen XS, Funk CD. Human 12(R)-lipoxygenase and the mouse ortholog: molecular cloning, expression, and gene chromosomal assignment. J Biol Chem 1998, 273: 33540.
  114. Sun D, Elsea SH, and Funk CD. Cloning of a human “epidermal-type” 12-lipoxygenase related gene and the chromosomal localization to 17p13. Cytogenetics and Cell Genetics 1998, 81:79.
  115. Sun D, Funk CD. Disruption of 12/15‑lipoxygenase expression in peritoneal macrophage: Enhanced utilization of 5‑lipoxygenase pathway and diminished oxidation of low-density lipoprotein.  J Biol Chem 1996, 271:24055-24062.
  116. Hu JH, Sun D, Zeng GQ, Lin AY, Rui YC.  Platelet adhesion to cultured bovine cerebral microvascular endothelial cells by stimulation of platelet activating factor and antagonism of drugs. Acta Pharmacol Sin, 1995, 16:318-321.
  117. Hu JH, Sun D, Zeng GQ, Lin AY, Rui YC. Effects of calcimycin on platelet adhesion to cultured bovine cerebral microvascular endothelial cells and its antagonism by drugs. Acta Pharmaceutica Sin, 1994, 29:335-339.
  118. Ji Y, Zeng GQ, Sun D. Drug antagonism of TNF induced proliferation of bovine cerebral microvascular smooth cells.  Acta Pharmaceutica Sin 1994, 29:86-89.
  119. Sun D, Huang TG, Zeng GQ, Rui YC. PAF production in bovine cerebral microvascular endothelial cells and its drug inhibition. Acta Pharmcol Sin 1993, 14:26-30.
  120. Sun D, Zeng GQ, Rui YC. Platelet activating factor and cerebrovascular disorders. Chin Pharmacol Bullet, 1993, 9:90.
  121. Zeng GQ, Ju DW, Sun D, Rui, YC.  Dauricine and Anisodamine inhibited leukotrines- and platelet activating factor induced DNA synthesis and proliferation of bovine cerebral microvascular smooth muscle cells in culture.  Acta Pharmacol Sin, 1993: 14:329-331.
  122. Zeng GQ, Rui YC, Sun D.  Effects of imperatorin and isoimperatorin on rabbit platelet aggregation and TXB2, cAMP production.  Acad J Sec Mil Med Univ, 1993, 14:369‑70.
  123. Zeng GQ, Wang XS, Sun D, Lin AY, Ji Y, Chu JX, Rui YC. Effects of 6‑(a‑a‑‑diphenyl acetylpiperazinyl) on rabbit platelet aggregation and TXB2, cAMP production. Acta Pharmaceutica Sinica 1993,28:256-259.
  124. Zeng GQ, Ju DW, Sun D, Huang TG, Rui YC. Effects of dauricine and tetrandrine on 3H‑WEB 2086 specific binding to bovine cerebral anterior arterial smooth muscle cells. Acta Pharmaceutica Sin 1993, 28:499-503.
  125. Sun D, Rui YC, Zeng GQ. Cultivation of bovine cerebral micro-vascular smooth muscle cells and the production of platelet activating factor. Chin J Anatomy 1992, 15:27.
  126. Sun D, Rui YC, Zeng GQ, Zhu J, Shen YA. Specific binding sites of platelet activating factor on intact bovine cerebral microvascular endothelial cells and antagonism of drugs. Acta Pharmacol Sin 1992, 13:326-329.
  127. Sun D, Rui YC, Zeng GQ. Cultivation and characterization of bovine cerebral microvascular endothelial cells. Acad J Sec Mil Med Univ 1992,13: 178.
  128. Sun D, Huang TG, Zeng GQ, Zhu J, Ju DW, Rui YC. Effects of platelet activating factor on the cerebrovascular permeability in rats and the protection by drug. Acta Pharmaceutica Sin 1992, 27(9): 651-655.
  129. Sun D, Rui YC, Zeng GQ, Zhu J. Effect of SZ‑1 on PAF induced arachidonic acid releases in cerebrovascular endothelial and smooth muscle cells. Acad J Sec Mil Med Univ 1992,13(4): 3.
  130. Zeng GQ, Ju DW, Sun D, Rui YC. Effects of Dauricine and anisodamine on LTS and PAF induced DNA synthesis of bovine anterior arteries smooth muscle cells. Acta Pharmaceutica Sin 1992, 27:561-565.
  131. Zeng GQ, Rui YC, Sun D. LTS and cerebrovascular disorders.  Pharmaceutical Information Bulletin, 1992, 10:5.
  132. Zeng GQ, Ju DW, Sun D, Rui YC.  Inhibition of 3H‑WEB 2086 specific binding to cultured bovine cerebromicrovascular smooth muscle cells by tetrandrine. Chin J Physiol Sci 1992, 8:375‑79.
  133. Zeng GQ, Rui YC, Sun D, Rui Y. Specific 3H‑LTC4 receptor on intact smooth muscle cells derived from bovine cerebral microvasculatures.  Acad J Sec Mil Med Univ, 1992,13: 318.
  134. Zeng GQ, Rui YC, Sun D, Shen YA. Leukotriene C4 receptors in cultured smooth muscle cells from bovine anterior cerebral arteries and microcerebrovasculatures.  Acta Pharmacol Sin, 1992, 13(6): 490-493.
  135. Rui YC, Sun D, Lin AY. Effect of dazoxiben on the metabolism of arachidonic acid in isolated basilar arteries. Acta Pharmacol Sin. 1990, 11:261-264.
  136. Rui YC, Zhang DZ, Sun D, Zeng GQ. Effect of silybin on production of oxygen free radical, lipoperoxide and leukotrienes in brain following ischemia and reperfusion. Acta Pharmacol Sin, 1990, 11:418-421.
  137. Rui YC, Sun D, Long K. Effect of dazoxiben on cerebrovascular resistance in rabbit.  Acta Pharmacol Sin, 1989, 10:342-345.
  138. Rui YC, Sun D. Effect of silybin on histamine release in mast cells. Commun Pharmacol Sin, 1989, 5:33.

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