DUXIN SUN is the J.G. Searle Endowed Professor of Pharmaceutical Sciences at the College of Pharmacy, as well as Director of the Pharmacokinetics Core. Dr. Sun received his Ph.D. in Pharmaceutical Sciences from the University of Michigan College of Pharmacy. He then worked as a researcher at Bristol-Myers Squibb, and as an assistant professor at the Ohio State University College of Pharmacy, before returning to the U-M College of Pharmacy in 2008. His research is supported by the National Institutes of Health, the Food and Drug Administration, and other grant agencies. Dr. Sun is also a member of the U-M Comprehensive Cancer Center.
RESEARCH The Sun Lab's research focuses on drug discovery and nanomedicine for cancer therapeutics. Specifically, they are currently working on: (A) Drug discovery targeting epigenetics and cancer stem cell targets, (B) Nanomedicine for targeted drug delivery and cancer therapy; (C) ADME and pharmacokinetics for lead compound optimization, and (D) Drug release in GI tract for modified release (MR) drug products.
Dr. Sun's research has made significant contributions to develop small molecules to inhibit novel cancer stem cell targets and protein-protein interactions in cancer stem cells. These small molecules can eliminate cancer stem cells to prevent tumor formation and metastasis. He also developed a nanotheranostics, which incorporates therapeutic agent and imaging probe into one nanoparticle, for cancer therapy and tumor imaging. More information on the lab's research programs can be found here.
PEOPLE The Sun Lab research team is made up of about thirty individuals, including graduate students, postdoctoral research fellows, research scientists, and PK Core staff, as well as visiting research scientists. We have students from the Pharmaceutical Sciences department at the College of Pharmacy, from the Program in Chemical Biology, and from the Cellular and Molecular Biology department at LS&A. Our lab includes researchers with degrees in chemistry, biology, mathematics, and engineering.
Each research program is led by a senior scientist—Dr. Hongwei Chen, Dr. Hebao Yuan, Dr. Joseph Burnett—and Dr. Bo Wen serves as the manager for the PK Core. You can learn more about our lab members here, and check for open positions in the lab here.
The Sun Lab is located at the North Campus Research Complex, Building 520, 1600 Huron Parkway, Ann Arbor, Michigan. Lab meetings are held weekly; the lab calendar is available here. For administrative concerns, please contact Marisa Gies, the lab's administrative assistant, at firstname.lastname@example.org.