We help you make informed decisions about the discovery, development, and refinement of therapeutics.
 
Explore the ways we can work together:

 

mass spectrometer

 

Bioanalysis and Liquid Chromatography Mass Spectrometry

 

Mass spectrometry (LC-MS) analysis of drug/compound concentration in biological specimens. We developed assays to measure over 2300 compounds, including several commercially available drugs. We work closely with the

Center for Discovery of New Medicines to accelerate drug discovery.

 

Lead Optimization image

 

Lead Optimization

 

Microsomal Stability, Metabolite ID, Protein Binding, Blood/Plasma Ratio.  Drug Metabolism studies, including Enzyme Identification, Inhibition, and Induction. We work closely with the Vahlteich Medicinal Chemistry Core to support lead optimization projects.

 

 

Mouse

Pre-Clinical Studies

 

We perform oral bioavailability, pharmacokinetic, and biodistribution studies in animal models. We access state-of-the-art facilities at UM In Vivo Animal Core to facilitate healthy and disease models for a range of drug discovery and development efforts.

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Clinical Studies

 

We assist with design of early phase clinical trials that involve assessment of exposure-response relationships. We collaborate with investigators who access resources offered through UM Institute for Clinical and Health Research

 

 

 

The PK Core gratefully acknowledges support from the College of Pharmacy and the U-M Comprehensive Cancer Center.

 

Our team

 

 

 

 

Enhance your funding, publication, and intellectual property potential:

 

27

Supported Grants

54

Supported Publications

7

Supported Patents

 

 

 

 

                      

Listing Row

Tuesday, September 3, 2013
Tuesday, September 3, 2013