Summary

Dr. Duxin Sun is a Professor in the Department of Pharmaceutical Sciences and J G Searle Endowed Professor in the College of Pharmacy at the University of Michigan. Dr. Sun serves as the Director of Pharmacokinetics (PK) Core. Dr. Sun also has joint appointment in the Chemical Biology program, the Interdisciplinary Medicinal Chemistry program, and University of Michigan’s Comprehensive Cancer Center.

Dr. Sun has published more than 220 papers, 120 meeting abstracts, 10 book chapters, and 12 U.S. patents. Dr. Sun has supervised 30 PhD students and 45 postdoctoral fellows and visiting scientists. Dr. Sun is a Fellow of American Association of Pharmaceutical Scientists (AAPS) and has served as chair of the PPB (Physical Pharmacy and Biopharmaceutics) section in AAPS. Dr. Sun serves on FDA Pharmaceutical Science and Clinical Pharmacology Advisory Committee. Dr. Sun is the President of the University of Michigan Association of Chinese Professors (UMACP) (2020-2022) and Vice President of American Chinese Pharmaceutical Association (ACPA) (2013-2019). Dr. Sun has served on study sections for NIH and FDA. 

Research Interests

  • DRUG DISCOVERY AND NANOMEDICINE 

    1. Breast Cancer Stem Cells and Therapeutics

    2. Drug Optimization Alters Tissue Targeting, Efficacy and Toxicity 

    3. Nanotechnology for Drug Delivery

    4. Viral-Like Nanoparticle (VLN) for Non-Capsid Antigen Delivery to Activate  B Cell Immunity 

    5. Drug Discovery to Treat P53/PTEN Deficient Triple Negative Breast Cancer

    6. Intubation and Wireless Sampling Device in GI Track For Microbiome Analysis and Drug Product Optimization

Selected Publications

  • Tan YS, Sansanaphongpricha K, Xie Y, Donnelly CR, Luo X, Heath BR, Zhao X, Bellile EL, Hu H, Chen H, Polverini PJ, Chen Q, Young S, Carey TE, Nör JE, Ferris RL, Wolf G, Sun D, Lei YL. Mitigating SOX2-potentiated immune escape of head and neck squamous cell carcinoma with a STING-inducing nanosatellite vaccine. Clin Cancer Res. 2018 May 16. [Epub ahead of print] PMID: 29769207

    Moody RR, Lo MC, Meagher JL, Lin CC, Stevers NO, Tinsley SL, Jung I, Matvekas A, Stuckey JA, Sun D. Probing the interaction between the histone methyltransferase/deacetylase subunit RBBP4/7 and the transcription factor BCL11A in epeigenetic complexes. J Biol Chem. 2018 Feb 9;293(6):2125-2136. PMCID: PMC5808772

    Koenigsknecht MJ, Baker JR, Wen B, Frances A, Zhang H, Yu A, Zhao T, Tsume Y, Pai MP, Bleske BE, Zhang X, Lionberger R, Lee A, Amidon GL, Hasler WL, Sun D. In vivo dissolution and systemic absorption of immediate release ibuprofen in human gastrointestinal tract under fed and fasted conditions. Mol Pharm. 2017 Dec 4;14(12):4295-4304. PMID: 28937221

    Burnett JP, Lim G, Shah RB, Lim R, Paholak HJ, McDermott SP, Sun L, Tsume Y, Bai S, Wicha MS, Sun D, Zhang T. Sulforaphane enhances the anticancer activity of taxanes against triple negative breast cancer by killing cancer stem cells. Cancer Lett. 2017 May 28;394:52-64. PMID: 28254410

    Sansanaphongpricha K, DeSantis MC, Chen H, Cheng W, Sun K, Wen B, Sun D. Multibuilding block Janus synthesized by seed-mediated self-assembly for enhanced photothermal effects and colored Brownian motion in an optical trap. Small. 2017 Feb;13(6):1603569. PMID: 27873448

    Paholak HJ, Stevers NO, Chen H, Burnett JP, He M, Korkaya H, McDermott SP, Deol Y, Clouthier SG, Luther T, Li Q, Wicha MS, Sun D. Elimination of epithelial-like and mesenchymal-like breast cancer stem cells to inhibit metastasis following nanoparticle-mediated photothermal therapy. Biomaterials. 2016 Oct;104:145-57. PMID: 27450902

    Sun L, Burnett JP, Gasparyan M., Xu F, Jiang H, Lin C-C, Myers I, Korkaya H, Liu Yajing, Connarn J, He H, Zhang N, Wicha MS, Sun D. Novel cancer stem cell targets during epithelial to mesenchymal transition in PTEN-deficient trastuzumab-resistant breast cancer. Oncotarget. 2016 Aug 9;7(32):51408-51422. PMCID: PMC5239484

    Yanyan Li, Tao Zhang, Hasan Korkaya, Suling Liu, Yanke Yu, Hsiu-Fang Lee, Bryan Newman, Shawn G. Clouthier, Steven J. Schwartz, Max S. Wicha, and Duxin Sun. Sulforaphane, a Dietary Component of Broccoli/Broccoli Sprouts, Inhibits Breast Cancer Stem Cells. Clinical Cancer Research, 2010,16: 2580-90.