Selected Publications

  • Miljković, M., Lozano*, S.A., Castellote, M.I., de-Cózar, C.D., Villegas, A.I., Gamallo, P., Jimenez-Alfaro-Martinez, D., Fernández-Alvaro, E.A., Ballell, Lluis, and Garcia, G.A., “Novel inhibitors that target bacterial virulence identified via HTS against intra-macrophage survival of Shigella flexneri”, mSphere (2023), https://doi.org/10.1128/msphere.00154-23.

     

  • Dow, G.T., Young, A.M., and Garcia, G.A., “Elucidation of the DNA-binding activity of VirF from Shigella flexneri for the icsA and rnaG promoters and characterization of the N-terminal domain to identify residues crucial for dimerization”, Journal of Bacteriology (2023), 205 (4), https://doi.org/10.1128/jb.00015-23. PMCID: PMC10127635.

     

  • Ragazzone, N.J., Dow, G.T., and Garcia, G.A., “Elucidating key interactions between VirF and the virB promoter in Shigella flexneri using E. coli MarA and GadX-based homology models and in vitro analysis of the DNA-binding domains of VirF and MarA”, Journal of Bacteriology (2022), 204 (9), https://doi.org/10.1128/jb.00143-22. PMCID: PMC9487632.

     

  • Ashkar, S.R., Rajeswaran, W., Lee, P.H., Thrasher, C.M., Franzblau, S.G., Murakami, K., Showalter, H.D.H., and Garcia, G.A., “Optimization of Benzoxazinorifamycins to Minimize hPXR Activation for Treatment of Tuberculosis and HIV Coinfection”, ACS Infectious Diseases (2022), https://doi.org/10.1021/acsinfecdis.1c00635, PMID:35772743.

     

  • Rajeswaran, W., Ashkar, S., Lee, P.H., Shin, Y., Franzblau, S.G., Murakami, K., Showalter, H.D.H., and Garcia, G.A., “Optimization of Benzoxazinorifamycins to Improve M. tuberculosis RNA Polymerase Inhibition and Treatment of Tuberculosis”, ACS Infectious Diseases, (2022), https://doi.org/10.1021/acsinfecdis.1c00636, PMID: 35772744.

     

  • Stefan, M.A., Velazquez, G.M., and Garcia, G.A., “High-throughput Screening to Discover Inhibitors of the CarD•RNA Polymerase Protein-Protein Interaction in Mycobacterium tuberculosis”, Nature Scientific Reports (2020), DOI: 10.1038/s41598-020-78269-3.  https://www.nature.com/articles/s41598-020-78269-3.epdf.

     

  • Stefan, M.A., Ugur, F.S., and Garcia, G.A., "Source of the Fitness Defect in Rifamycin-Resistant M. Tuberculosis RNA Polymerase and the Mechanism of Compensation by Secondary Mutations”, Antimicrobial Agents and Chemotherapy (2018),62 (6), e00164-18, 1-13.

     

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Click here to go to Michigan Experts to see a complete list of publications.

 

Listing Row

Tuesday, November 4, 2014
Tuesday, November 4, 2014