Selected Publications

  • Ashkar, S.R., Rajeswaran, W., Lee, P.H., Thrasher, C.M., Franzblau, S.G., Murakami, K., Showalter, H.D.H., and Garcia, G.A., “Optimization of Benzoxazinorifamycins to Minimize hPXR Activation for Treatment of Tuberculosis and HIV Coinfection”, ACS Infectious Diseases (2022), https://doi.org/10.1021/acsinfecdis.1c00635, PMID:35772743.

     

  • Rajeswaran, W., Ashkar, S., Lee, P.H., Shin, Y., Franzblau, S.G., Murakami, K., Showalter, H.D.H., and Garcia, G.A., “Optimization of Benzoxazinorifamycins to Improve M. tuberculosis RNA Polymerase Inhibition and Treatment of Tuberculosis”, ACS Infectious Diseases, (2022), https://doi.org/10.1021/acsinfecdis.1c00636, PMID: 35772744.

     

  • Stefan, M.A., Velazquez, G.M., and Garcia, G.A., “High-throughput Screening to Discover Inhibitors of the CarD•RNA Polymerase Protein-Protein Interaction in Mycobacterium tuberculosis”, Nature Scientific Reports (2020), DOI: 10.1038/s41598-020-78269-3.  https://www.nature.com/articles/s41598-020-78269-3.epdf

     

  • Stefan, M.A., Ugur, F.S., and Garcia, G.A., "Source of the Fitness Defect in Rifamycin-Resistant M. Tuberculosis RNA Polymerase and the Mechanism of Compensation by Secondary Mutations”, Antimicrobial Agents and Chemotherapy (2018),62 (6), e00164-18, 1-13

     

  • Scharf, N.T., Kontos, A., Molodtsov, V., Murakami, K.S., and Garcia, G.A., “Novel Chemical Scaffolds for Inhibition of Rifamycin-Resistant RNA Polymerase Discovered from High-Throughput Screening”, SLAS Discovery (2017), 22 (3), 287-297, PMCID: PMC5323270.

     

  • Molodtsov, V., Scharf, N.T., Stefan, M.A., Garcia, G.A., and Murakami, K.S., “Structural Basis for Rifampin-Resistance of Bacterial RNA Polymerase by Clinically Important Rifampin Resistant Mutations”, Molecular Microbiology (2017), 103 (6), 1034-1045, PMCID: PMC5344776.

     

  • Emanuele, A.A. and Garcia, G.A., “Mechanism of Action and Initial, In vitro SAR of an Inhibitor of the Shigella flexneri Virulence Regulator VirF”, PLOS One (2015), e0137410 PMCID: PMC4564171.

     

View all publications

Our work (Molodtsov et al.) has been featured on the cover of the July 11, 2013 issue of the Journal of Medicinal Chemistry.

Listing Row

Tuesday, November 4, 2014
Tuesday, November 4, 2014