Quantitative LC-MS Analysis & Mass Spectrometry Imaging
Quantitative LC-MS Analysis & Mass Spectrometry Imaging
In partnership with Michigan Drug Discovery, we analyze drug/compound concentration in biological specimens and develop assays, having measured more than 2,300 compounds including commercially available drugs.
Small Molecules
Small Molecules
Develop LC-MS assays, optimized for the biological and non-biological matrix samples of interest. We work with both commercially available drugs and new chemical entities.
Large Molecules
Large Molecules
Use of LC-MS assays to quantify therapeutic peptides and proteins for the development of novel therapeutics that include large protein molecules.
Tissue Analysis
Tissue Analysis
Utilize the cutting-edge bead-beater system to homogenize animal, plant and microbiologic samples to quantify extracellular and intercellular concentrations of your compound or metabolites of interest.
Biomarker Measurement
Measure amino acids and bile acids to support metabolomics and assessment of physiologic changes, particularly helpful for longitudinal assessment of compounds in vivo.
Formulation Analysis
Understand the in vitro stability of your compound based on environmental factors or acceptable excursion standards. Pharmaceutical modifications may help to improve the solubility and stability of your compound in vivo.
Method Development
Access state-of-the art mass spectrometry instruments and technical expertise to meet your low sensitivity and high specificity needs. Our analytical methods are run in accordance with FDA guidance and standards.
MS Imaging
Visualize the location of known or unknown molecules on tissue sections utilizing Mass Spectrometry Imaging (MSI), a label-free MALDI-MSI technology. This technology can be used to image any potential molecules (without the need for labeling) to study cancer cell heterogeneity, tumor microenvironment, metabolism, biomarker identification and drug distribution.
LC-MS bioanalysis
- Advanced LC-MS/MS bioanalysis method development.
- Method transfer and method qualification.
- Quantitative analysis of small molecular and proteins from biological, food or environment samples.
- Drug and metabolite analysis to support PK/PD study on medicinal research.
- Bioanalysis for clinical study by the validated method according to the FDA guidance.
- Chemical compound identification and structure elucidation.
Advanced mass spectrometry application
- Mass spectrometry imaging on tissue samples to visualize or provide spatial information of drugs and their metabolites, peptides, lipids, metabolisms and proteins and their modification.
- Biomarker identification and characterization.
- Targeted metabolomics for bile acid, amino acid and glucose.
- Targeted lipidomics.
Questions?
If you have questions or would like to utilize our services, please reach out to us.
