This course develops mathematical principles with a strong emphasis on ordinary and partial differential equations that are applied in the physical pharmacy and pharmacokinetic disciplines within the pharmaceutical sciences. This course is currently required of first year graduate students in the Pharmaceutical Sciences Department that have not taken an acceptable differential equations course when entering the program.

Prerequisites: Pharmaceutical Sciences PhD students OR MATH 115 and 116; (C or better) and Junior or Senior standing or Rackham Graduate Standing. Minimum grade requirement: C for those would need MATH 115 and 116

Terms: Fall

This course is the third of four required courses in the pharmaceutical sciences curriculum. Course content includes the absorption, distribution, metabolism, and excretion of drugs and drug-related species by the body. Emphasis is placed on the use (not the derivation) of pharmacokinetic/dynamic models and equations. Additional emphasis is placed on designing suitable dosage regimens for the treatment and prevention of disease in humans. Three lecture hours and one discussion hour a week.

Prerequisites: Pharmaceutical Sciences 518

Terms: Fall

This course focuses on the ADME concepts of absorption, distribution, metabolism, excretion, and basic pharmacokinetic/dynamic modeling.

Prerequisites: Graduate Student Standing

Terms: Fall

This course focuses on the ADME concepts of absorption, distribution, metabolism, excretion, and basic pharmacokinetic/dynamic modeling.

Prerequisites: Graduate Student Standing

Terms: Fall

This course focuses on the ADME concepts of absorption, distribution, metabolism, excretion, and basic pharmacokinetic/dynamic modeling.

Prerequisites: Graduate Student Standing

Terms: Fall

This course covers analytical methods used in designing and characterizing pharmaceutical products, from small molecules to biologics. Students learn the rationale behind each technique, application to dosage forms, and data interpretation. Both theory and examples, including high-throughput methods, are discussed throughout.

Prerequisites: Graduate Student Standing

Terms: Fall

This course covers analytical methods used in designing and characterizing pharmaceutical products, from small molecules to biologics. Students learn the rationale behind each technique, application to dosage forms, and data interpretation. Both theory and examples, including high-throughput methods, are discussed throughout.

Prerequisites: Graduate Student Standing

Terms: Fall

This course presents the mechanistic biopharmaceutics of conventional and biologic dosage forms. Topics include oral and alternative-route drug absorption, pharmacokinetic concepts of bioavailability and dissolution, and the discovery, manufacture, formulation, analysis, and regulation of biologic products including monoclonal antibodies, recombinant proteins, cell therapies, and biosimilars.

Prerequisites: Graduate student standing

Terms: Winter

This course presents the mechanistic biopharmaceutics of conventional and biologic dosage forms. Topics include oral and alternative-route drug absorption, pharmacokinetic concepts of bioavailability and dissolution, and the discovery, manufacture, formulation, analysis, and regulation of biologic products including monoclonal antibodies, recombinant proteins, cell therapies, and biosimilars.

Prerequisites: Graduate student standing

Terms: Winter

This course examines physical chemistry and chemical kinetics in pharmaceutical dosage forms and drug delivery systems, emphasizing thermodynamics, solubility, interfacial and solid-state properties, mass transport, dissolution, membrane permeation, and chemical degradation. Qualitative and quantitative principles are applied to the design, characterization, and performance of dosage forms, primarily for small-molecule drugs.

Prerequisites: Graduate student standing.

Terms: Winter

This course examines physical chemistry and chemical kinetics in pharmaceutical dosage forms and drug delivery systems, emphasizing thermodynamics, solubility, interfacial and solid-state properties, mass transport, dissolution, membrane permeation, and chemical degradation. Qualitative and quantitative principles are applied to the design, characterization, and performance of dosage forms, primarily for small-molecule drugs.

Prerequisites: Graduate student standing.

Terms: Winter

This course covers fundamental concepts essential for the discovery, development and characterization of biopharmaceuticals. Topics include basic immunology, molecular biology and cloning, in vitro protein library generation and screening, antibody discovery and engineering, biophysical characterization, and protein expression and purification.

Prerequisites: Bio 172 or equivalent AND ChE 330 or BiomedE 221 or Chem 230, or graduate standing or enrollment in PharmD program

Terms: Winter

This course covers fundamental concepts essential for the discovery, development and characterization of biopharmaceuticals. Topics include basic immunology, molecular biology and cloning, in vitro protein library generation and screening, antibody discovery and engineering, biophysical characterization, and protein expression and purification.

Prerequisites: Bio 172 or equivalent AND ChE 330 or BiomedE 221 or Chem 230, or graduate standing or enrollment in PharmD program

Terms: Winter

Pharmaceutical Biotechnology plays crucial roles in today's healthcare. The top selling drugs are monoclonal antibodies, and nearly half of the pharma pipeline and newly approved products are biopharmaceuticals. This course will cover the important facets of antibodies, recombinant proteins, and vaccines as pharmaceutical agents. Basics of protein structure and analysis will be introduced, and methods for production, isolation, and purification of recombinant proteins will be described. Potential chemical and physical degradation processes and strategies for circumventing these difficulties will be discussed. We will also explore the immunological basis of vaccinology and immunotherapy, types of vaccines and immunotherapies in the clinic and in the development for cancer, autoimmune disease, and infectious pathogens, including the current CoVID-19 pandemic, and the latest research for antibody-, peptide-, nucleic acid- and cell-based therapeutics.

Prerequisites: Third Year PharmD Students

Terms: Winter

The second in a sequence of three courses needed for the PharmD Investigations requirement. This semester of the series is designed for students to obtain hands on experience in conducting their research and collecting and analyzing all research data. Students work under the supervision of their faculty mentor to develop data collection forms and methods to archive data in a way that facilitates their analysis.

Prerequisites: Pharmaceutical Sciences PharmD Investigations - Research Proposal

Terms: Winter

Reports on current studies in the field of Pharmaceutical Sciences.

Terms: Fall/Winter

Election for dissertation work by doctoral students not yet admitted to candidacy.

Prerequisites: Advanced doctoral student status

Terms: Fall/Winter

Election for dissertation work by doctoral students admitted to candidacy.

Prerequisites: Doctoral candidacy

Terms: Fall/Winter