DIRECTORY
Medicinal Chemistry
Meet the Medicinal Chemistry Team
Neamati, Nouri , PhD
John G. Searle Professor of Medicinal Chemistry
Research Topics
Structure- and ligand-based drug design
Cellular and molecular pharmacology
Preclinical drug development
Select targets of interest include: ER stress (GRP78 and PDI); DNA-binding proteins (HIV-1 integrase, APE-1); Protein-protein interactions (HIV-1 integrase-LEDGF/p75, integrin v 3 , BCL2, MDM2-p53); GPCRs (CXCR2, CXCR4); Mitochonrial-targeted agents; Transcription factors (STAT3, Nrf2)
Nikolovska-Coleska, Zaneta , PhD
Professor of Pathology Director, Molecular & Cellular Pathology PhD Program Associate Director, Program in Biomedical Sciences (PIBS) University of Michigan Medical School; and Faculty Associate in the Interdepartmental Program in Medicinal Chemistry
O'Meara, Matthew
Assistant Professor
Ohi, Melanie
Rowena G. Matthews Collegiate Professor in the Life Sciences; Research Associate Professor, Life Sciences Institute; Associate Professor of Cell and Developmental Biology, Medical School; and Faculty Associate in the Interdepartmental Program in Medicinal Chemistry
Rech, Jason
Director of the Vahlteich Medicinal Chemistry Core, Associate Research Scientist in Medicinal Chemistry
Samanta, Soma , PhD
Assistant Research Scientist
Scott, Emily
F.F. Blicke Collegiate Professor of Medicinal Chemistry, College of Pharmacy; Professor of Pharmacology, Medical School; Professor of Biological Chemistry, Medical School; and Professor of Biophysics, College of Literature, Science, and the Arts
Scott, Peter , PhD
Professor of Medicinal Chemistry, Professor of Radiology, Program Assistant of Cyclotron Facility, Radiology, Section Head, Nuclear Medicine, Radiology and Professor of Pharmacology, Medical School
Sexton, Jonathan
Assistant Professor of Internal Medicine, Medical School, and Assistant Professor of Medicinal Chemistry, College of Pharmacy
Sherman, David , PhD
Hans W. Vahlteich Professor of Medicinal Chemistry, College of Pharmacy; Professor of Microbiology and Immunology, Medical School; Professor of Chemistry, College of Literature, Science, and the Arts; Research Professor, Life Sciences Institute; Co-Director, Pharmacological Sciences Training Program (PSTP)
Smith, Janet , PhD
Margaret J. Hunter Collegiate Professor in the Life Sciences and Professor of Biological Chemistry, Medical School; Research Professor, Life Sciences Institute; Associate Director, Department of Life Sciences Institute; and Faculty Associate in the Interdepartmental Program in Medicinal Chemistry
Sztain, Terra , PhD
Assistant Professor
Toogood, Peter , PhD
Research Associate Professor and Director of Michigan Drug Discovery (MDD)
Research Topics
The goal of our medicinal research is to discover new biologically active molecules for the potential treatment of challenging diseases such as pancreatic cancer and myalgic encephalomyelitis/chronic fatigue syndrome. Our approach employs computational chemistry methods, as well as batch and continuous flow organic synthesis.
Traynor, John
Edward F Domino Research Professor and Professor of Medicinal Chemistry, College of Pharmacy Professor and Associate Chair for Research, Department of Pharmacology, Medical School
Tripathi, Ashootosh
Director, UM-Natural Products Discovery Core; Associate Research Scientist, Life Sciences Institute; Research Associate Professor of Medicinal Chemistry, College of Pharmacy
Research Topics
My research directly addresses the eminent health threat lurking over human race due to absence of any plausible next generation antibiotic/ anticancer candidate in the clinical pipeline. I use a multipronged strategy to discover and characterize novel drug leads from microbial cultures by using sophisticated mainstream techniques as well as through harnessing the complete biosynthetic potential of cryptic or minimally expressed secondary metabolite gene clusters. In addition, unique target based approaches are also envisaged to identify potent anticancer, antiviral, antidiabetic, and antibiotic inhibitors, which complements the aforementioned strategy and comprehensively exploits the secondary metabolite capability of microbes for obtaining new druggable molecular entities.
Walter, Nils
Francis S Collins Collegiate Professor of Chemistry
Wang, Shaomeng , PhD
Warner-Lambert/Parke-Davis Professor of Internal Medicine, Medical School, and Professor of Medicinal Chemistry, College of Pharmacy