Faculty

Name	Contact Info	Research Interests
Kyung-Dall Lee Professor of Pharmaceutical Sciences	734/647-4941 kdlee@umich.edu 3064 Pharm
James Moon John G. Searle Associate Professor of Pharmaceutical Sciences, College of Pharmacy, and Associate Professor of Biomedical Engineering, College of Engineering	734/763-0911 moonjj@umich.edu B10 Rm A190	Nanotechnology Biomaterials View more
Carlos Rodriguez LEO Intermittent Lecturer	734/615-3749 carodrig@umich.edu 2002 Pharm
Nair Rodriguez-Hornedo Professor of Pharmaeceutical Sciences	734/763-0101 nrh@umich.edu 3002 Pharm
Gustavo Rosania Professor of Pharmaceutical Sciences	734/763-1032 grosania@umich.edu 3062 Pharm	Exploring the application of in silico models, such as the cell-based molecular transport simulations we use in our experiments, to pharmaceutical discovery and development Exploring cell-based molecular transport simulations as a way to probe the role of microscopic drug transport as a determinant of drug absorption, distribution, metabolism, and excretion View more
Anna Schwendeman Associate Professor of Pharmaceutical Sciences	734/763-4056 annaschw@umich.edu B20 Rm 102W	Rational design of novel synthetic HDL nanomedicines for treatment of atherosclerosis by designing new ApoA-I mimic peptides and optimizing phospholipid composition Therapeutic applications of HDL nanomedicines for treatment of Alzheimer’s disease, septic shock, acute lung injury, lupus and diabetic nephropathy View more
Steven Schwendeman Chair and Ara G. Paul Professor of Pharmaceutical Sciences, College of Pharmacy, and Professor of Biomedical Engineering, College of Engineering	734/615-6574 schwende@umich.edu B20 Rm 102W	Physical and chemical stability of microencapsulated bioactive agents. We examine the underlying molecular mechanisms responsible for the instability of substances, particularly proteins and other biomacromolecules, when encapsulated in the most commonly used material for controlled release, copolymers derived from lactic and glycolic acids (PLGA) and related biodegradable polymers. Microencapsulation of biomacromolecules. We examine the underlying molecular mechanisms that govern microencapsulation, particularly for process-sensitive biomacromolecules. Through our mechanistic findings related to polymer/drug behavior in other projects, we have devised two new approaches for facile microencapsulation of biomacromolecular therapeutics with strong advantages over existing methods. These new methods will be published shortly and related patents are pending. View more
David Smith John G. Wagner Collegiate Professor of Pharmacy	734/647-1431 smithb@umich.edu 4008 Pharm	Pharmacokinetics and biopharmaceutics Drug transport mechanisms and transporters View more
Sejin Son Assistant Research Scientist	734/763-7118 ssejin@umich.edu B020-326W
Duxin Sun J. G. Searle Professor of Pharmaceutical Sciences, College of Pharmacy	734/615-8740 duxins@umich.edu B520 Rm 3353	Breast Cancer Stem Cells and Therapeutics The goal of this project is to visualize the cancer stem cells hierarchy to answer questions for how heterogeneous breast cancer cells are generated by breast cancer stem cells? How chemotherapy alters heterogeneity by changing breast cancer stem cells? Why chemotherapy can not “cure” cancer? How to identify drugs or targets to eliminate different populations of heterogeneous cancer cells in order to “cure” cancer. Drug Discovery to Treat P53/PTEN Deficient Triple Negative Breast Cancer Among four types of breast cancers, triple negative breast cancer (TNBC) still lacks treatment options. Triple negative breast cancer (TNBC) exhibits high frequencies of p53 and PTEN genetic aberrations, with 84% and 35%, respectively, which is associated with metastasis, low therapeutic response, and poor prognosis. However, the concurrent p53/PTEN deficiency in TNBC is not actionable due to the lack of molecular targets. The goal of this project is to identify specific therapeutic target for drug discovery to treat P53/PTEN deficient TNBC. View more