Summary

Dr. Scott’s research focus is on the structure and function of human cytochrome P450 enzymes.  These membrane enzymes have two types of important physiological roles.  Many human P450 enzymes are involved the metabolism of xenobiotics, including procarcinogens and pharmaceutical agents of all kinds.  In this context the Scott lab is interested in inhibiting the activation of procarcinogens in vivo (such as those in tobacco smoke) to prevent cancer initiation.  Human P450 enzymes are also involved in the synthesis and catabolism of important endogenous compounds such as steroid hormones, fatty acids, retinoic acid, eicosanoids and vitamins.  The Scott lab is investigating these P450 enzymes as targets for drug design themselves in specific disease pathways.  Recent efforts have particularly focused on understanding the biochemistry and structural biology of CYP17A1, a target for prostate cancer, with efforts toward more effective drug design.  Various biochemical, biophysical, and structural biology approaches are used to investigate these versatile enzymes, but with an emphasis on X-ray crystallography and NMR spectroscopy.

Recent Publications

  • Silvia Bonomo; Cecilie H. Hansen; Elyse M. Petrunak; Emily E. Scott; Bjarne Styrishave; Flemming Steen Jørgensen; Lars Olsen Promising Tools in Prostate Cancer Research. Scientific Reports. 2016;6():
  • D. Fernando Estrada; Jennifer S. Laurence; Emily E. Scott Cytochrome P450 17A1 interactions with the FMN domain of its reductase as characterized by NMR. Journal of Biological Chemistry. 2016;291(8):3990-4003
  • Rahul Yadav; Elyse M. Petrunak; D. Fernando Estrada; Emily E. Scott Structural insights into the function of steroidogenic cytochrome P450 17A1. Molecular and Cellular Endocrinology. 2016;():
  • Emily E. Scott; C. Roland Wolf; Michal Otyepka; Sara C. Humphreys; James R. Reed; Colin J. Henderson; Lesley A. Mclaughlin; Markéta Paloncýová; Veronika Navrátilová; Karel Berka; Pavel Anzenbacher; Upendra P. Dahal; Carlo Barnaba; James A. Brozik; Jeffrey P. Jones; D. Fernando Estrada; Jennifer S. Laurence; Ji Won Park; Wayne L. Backes The role of protein-protein and protein-membrane interactions on P450 function. Drug Metabolism and Disposition. 2016;44(4):576-590
  • Eric F. Johnson; J. Patrick Connick; James R. Reed; Wayne L. Backes; Manoj C. Desai; Lianhong Xu; D. Fernando Estrada; Jennifer S. Laurence; Emily E. Scott Correlating structure and function of drug-metabolizing enzymes. Drug Metabolism and Disposition. 2014;42(1):9-22