Summary

Education/Training

    2012    Postdoc, Materials Science and Biological Engineering, MIT (HHMI)    

    2008    PhD, Bioengineering, Rice University

    2002    BS, Bioengineering, University of California, Berkeley

Research Statement

The Moon Laboratory is interested in the development of novel therapeutics at the interface of immunology, pharmaceutics, and engineering. Specifically, we are developing new drug delivery systems that can enhance targeting of antigen and adjuvant to lymphoid organs, thereby manipulating immune functions in the context of cancer, infectious diseases, and autoimmunity.  Our translational research focused on immunoengineering utilizes tools of nanotechnology, biomaterials, drug delivery, tissue engineering, and advanced in vitro/in vivo high-throughput methods to detect and improve immune functions. One thrust of our research is the development of a nanoparticle vaccine that can induce anti-tumoral cellular immune responses for cancer immunotherapy. The second thrust in the lab focuses on the synthesis of novel biomaterials for mucosal immunization against infectious pathogens, including HIV.

Awards
  2017    Emerald Foundation Distinguished Investigator Award
  2017    Rice University Outstanding Bioengineering Alumnus Award
  2017    University of Michigan Senior Forbes Scholar
  2017    Cellular and Molecular Bioengineering Young Innovator
  2016    National Science Foundation CAREER Award
  2016    DoD Career Development Award
  2015    Melanoma Research Alliance Young Investigator Award
  2014    AAPS New Investigator Award
  2012    NIH K22 Research Scholar Development Award 
  2012    American Association of Immunologist Trainee Award
  2011    IEEE-EMBS Harvard Wyss Institute Award for Translational Research
  2010    TERMIS Young Investigator Award
  2008    Mary F.D. Morse Graduate Fellowship Award 
  2007    Graduate Student Research Award, North American Vascular Biology Organization
  2006    Sigma Xi Graduate Student Research Award 

Research Interests

  • Nanotechnology

  • Biomaterials

  • Drug delivery systems

  • Cancer immunotherapy

  • Vaccine design and development

Selected Publications

  • Fan Y, Kuai R, Xu Y, Ochyl LJ, Irvine DJ, and Moon JJ*. Immunogenic cell death amplified by co-localized adjuvant delivery for cancer immunotherapy. DOI: 10.1021/acs.nanolett.7b03218, 2017, Nano Letters.

     

    Kuai R, Ochyl LJ, Bahjat KS, Schwendeman A* and Moon JJ*. Designer vaccine nanodiscs for personalized cancer immunotherapy. 16, 4, 489-496, 2017, Nature Materials

     

    Kuai R, Li D, Chen YE, Moon JJ*, and Schwendeman A*. High density lipoproteins: nature’s multifunctional nanoparticles, 10, 3, 3015-41, 2016, ACS Nano.

     

    Li AV*, Moon JJ*, Abraham W, Elkhader J, Suh K, Yen M, Im EJ, Barouch DH, and Irvine DJ. Generation of robust effector memory T-cell-based mucosal and systemic immunity with pulmonary nanoparticle vaccination, 204ra130, 2013, Science Translational Medicine.

     

    Moon JJ, Suh H, Li AV, Ockenhouse CF, Yadava A, and Irvine DJ. Enhancing humoral responses to a malaria antigen with nanoparticle vaccines that expand Tfh cells and promote germinal center induction, 109, 1080-5, 2012, PNAS.

     

    Moon JJ, Suh H, Bershteyn A, Stephan MT, Liu H, Huang B, Sohail M, Luo S, Um SH, Chiu W, and Irvine DJ. Interbilayer-crosslinked multilamellar vesicles for potent humoral and cellular immune responses, 10, 243-251, 2011, Nature Materials.

     

    Stephan MT, Moon JJ, Um SH, Bershteyn A, and Irvine DJ. Therapeutic cell engineering with surface-conjugated synthetic nanoparticles, 16, 1035-41, 2010, Nature Medicine.