James Moon, PhD
2012 Postdoc, Materials Science and Biological Engineering, MIT (HHMI)
2008 PhD, Bioengineering, Rice University
2002 BS, Bioengineering, University of California, Berkeley
The Moon Laboratory is interested in the development of novel therapeutics at the interface of immunology, pharmaceutics, and engineering. Specifically, we are developing new drug delivery systems that can enhance targeting of antigen and adjuvant to lymphoid organs, thereby manipulating immune functions in the context of cancer, infectious diseases, and autoimmunity. Our translational research focused on immunoengineering utilizes tools of nanotechnology, biomaterials, drug delivery, tissue engineering, and advanced in vitro/in vivo high-throughput methods to detect and improve immune functions. One thrust of our research is the development of a nanoparticle vaccine that can induce anti-tumoral cellular immune responses for cancer immunotherapy. The second thrust in the lab focuses on the synthesis of novel biomaterials for mucosal immunization against infectious pathogens, including HIV.
2017 Emerald Foundation Distinguished Investigator Award
2017 Rice University Outstanding Bioengineering Alumnus Award
2017 University of Michigan Senior Forbes Scholar
2017 Cellular and Molecular Bioengineering Young Innovator
2016 National Science Foundation CAREER Award
2016 DoD Career Development Award
2015 Melanoma Research Alliance Young Investigator Award
2014 AAPS New Investigator Award
2012 NIH K22 Research Scholar Development Award
2012 American Association of Immunologist Trainee Award
2011 IEEE-EMBS Harvard Wyss Institute Award for Translational Research
2010 TERMIS Young Investigator Award
2008 Mary F.D. Morse Graduate Fellowship Award
2007 Graduate Student Research Award, North American Vascular Biology Organization
2006 Sigma Xi Graduate Student Research Award
Drug delivery systems
Vaccine design and development
Fan Y, Kuai R, Xu Y, Ochyl LJ, Irvine DJ, and Moon JJ*. Immunogenic cell death amplified by co-localized adjuvant delivery for cancer immunotherapy. DOI: 10.1021/acs.nanolett.7b03218, 2017, Nano Letters.
Kuai R, Ochyl LJ, Bahjat KS, Schwendeman A* and Moon JJ*. Designer vaccine nanodiscs for personalized cancer immunotherapy. 16, 4, 489-496, 2017, Nature Materials.
Kuai R, Li D, Chen YE, Moon JJ*, and Schwendeman A*. High density lipoproteins: nature’s multifunctional nanoparticles, 10, 3, 3015-41, 2016, ACS Nano.
Li AV*, Moon JJ*, Abraham W, Elkhader J, Suh K, Yen M, Im EJ, Barouch DH, and Irvine DJ. Generation of robust effector memory T-cell-based mucosal and systemic immunity with pulmonary nanoparticle vaccination, 204ra130, 2013, Science Translational Medicine.
Moon JJ, Suh H, Li AV, Ockenhouse CF, Yadava A, and Irvine DJ. Enhancing humoral responses to a malaria antigen with nanoparticle vaccines that expand Tfh cells and promote germinal center induction, 109, 1080-5, 2012, PNAS.
Moon JJ, Suh H, Bershteyn A, Stephan MT, Liu H, Huang B, Sohail M, Luo S, Um SH, Chiu W, and Irvine DJ. Interbilayer-crosslinked multilamellar vesicles for potent humoral and cellular immune responses, 10, 243-251, 2011, Nature Materials.
Stephan MT, Moon JJ, Um SH, Bershteyn A, and Irvine DJ. Therapeutic cell engineering with surface-conjugated synthetic nanoparticles, 16, 1035-41, 2010, Nature Medicine.