Summary

Education/Training

2012 Postdoc, Materials Science and Biological Engineering, MIT (HHMI)
2008 PhD, Bioengineering, Rice University
2002 BS, Bioengineering, University of California, Berkeley

Research Statement

The Moon Lab at the University of Michigan is developing new immunotherapies and vaccines at the interface of immunology, pharmaceutics, and engineering. We design new drug delivery systems for improving immune functions in the context of cancer, autoimmune diseases, and the gut microbiome. Our translational immunoengineering research utilizes tools of nanotechnology, biomaterials, drug delivery, tissue engineering, and advanced high-throughput methods to detect and improve immune functions.

Research Interests

  • We are developing new drug delivery systems for improving immune functions in the context of cancer, autoimmune diseases, and the gut microbiome.

Selected Publications

  • Han K, Xie F, Animasahun O, Nenwani M, Kitamoto S, Kim Y, Phoo MT, Xu J, Wuchu F, Omoloja K, Achreja A, Choppara S, Li Z, Gong W, Cho YS, Dobson H, Ahn J, Zhou X, Huang X, An X, Kim A, Xu Y, Wu Q, Lee SH, O’Konek JJ, Xie Y, Lei YL, Kamada N, Nagrath D, Moon JJ§. Inulin-gel-based oral immunotherapy remodels the small intestinal microbiome and suppresses food allergy. doi: 10.1038/s41563-024-01909-w, 2024. Nature Materials

  • Sun S, Zhou X, Shi X, Abed OA, An X, Lei YL, Moon JJ§. Strategies for the development of metalloimmunotherapies.  doi: 10.1038/s41551-024-01221-7, 2024. Nature Biomedical Engineering

  • Sun X, Zhang Y, Li J, Park KS, Han K, Zhou X, Xu Y, Nam J, Xu J, Shi X, Wei L, Lei YL, Moon JJ. Amplifying STING Activation by Cyclic Dinucleotide-Manganese Particles for Local and Systemic Cancer Metalloimmunotherapy. 16, 11, 1260-1270, 2021, Nature Nanotechnology. 

  • Han K, Nam J, Xu J, Sun X, Huang X, Animasahun O, Achreja A, Joen JH, Pursley B, Kamada N, Chen GY, Nagrath D, Moon JJ§. Generation of systemic antitumour immunity via the in situ modulation of the gut microbiome by an orally administered inulin gel. 5, 1377-1388, 2021, Nature Biomedical Eng. 

  • Lee Y, Sugihara K, Gillilland MG 3rd, Jon S, Kamada N, Moon JJ§. Hyaluronic acid–bilirubin nanomedicine for targeted modulation of dysregulated intestinal barrier, microbiome and immune responses in colitis. 19, 1, 118-126, 2020, Nature Materials. 

  • Scheetz L*, Park KS*, Li Q, Lowenstein PR, Castro MG, Schwendeman A, Moon JJ§. Engineering patient-specific cancer immunotherapies. 3, 10, 768-782, 2019, Nature Biomedical Engineering. 

  • Nam J*, Son S*, Park KS, Zou W, Shea L, Moon JJ§. Cancer nanomedicine for combination cancer immunotherapy. 4, 398-414, 2019, Nature Reviews Materials. 

  • Nam J*, Son S*, Ochyl LJ, Kuai R, Schwendeman A, and Moon JJ§. Chemo-photothermal therapy combination elicits anti-tumor immunity against advanced metastatic cancer. 9, 1, 1074, 2018, Nature Communications. 

  • Kuai R, Ochyl LJ, Bahjat KS, Schwendeman A§ and Moon JJ§. Designer vaccine nanodiscs for personalized cancer immunotherapy. 16, 4, 489-496, 2017, Nature Materials. §Co-corresponding authors.