Summary

Education/Training

    2012    Postdoc, Materials Science and Biological Engineering, MIT     

    2008    PhD, Bioengineering, Rice University

    2002    BS, Bioengineering, University of California, Berkeley

Research Statement

The Moon Laboratory is interested in the development of therapeutics and diagnostics at the interface of immunology and engineering. Specifically, we are developing new drug delivery systems that can enhance targeting of antigen and adjuvant to lymphoid organs, thereby manipulating immune functions in the context of cancer, infectious diseases, and autoimmunity.  Our translational research focused on immunoengineering utilizes tools of nanotechnology, biomaterials, drug delivery, tissue engineering, and advanced in vitro/in vivo high-throughput methods to detect and improve immune functions. One thrust of our research is the development of a nanoparticle vaccine that can induce anti-tumoral cellular immune responses for cancer immunotherapy. The second thrust in the lab focuses on the synthesis of novel biomaterials for mucosal immunization against infectious pathogens, including HIV.

Awards

  2012    NIH K22 Research Scholar Development Award  
  2012    American Association of Immunologist Trainee Award
  2011    IEEE-EMBS Harvard Wyss Institute Award for Translational Research
  2010    Young Investigator Award (Tissue Engineering and Regenerative Medicine International Society)
  2008    Mary F.D. Morse Graduate Fellowship Award  
  2007    Graduate Student Research Award, North American Vascular Biology Organization
  2006    Sigma Xi Graduate Student Research Award 

Research Interests

  • Nanotechnology

  • Biomaterials

  • Drug delivery systems

  • Cancer immunotherapy

  • Vaccine design and development

Selected Publications

  • Li AV*, Moon JJ*, Abraham W, Elkhader J, Suh K, Yen M, Im EJ, Barouch DH, and Irvine DJ. Generation of robust effector memory T-cell-based mucosal and systemic immunity with pulmonary nanoparticle vaccination, 204ra130, 2013, Science Translational Medicine.

  • Moon JJ, Huang B, and Irvine DJ. Engineering nano- and micro-particles to tune immunity, 24, 3724-46, 2012, Advanced Materials.

  • Moon JJ, Suh H, Li AV, Ockenhouse CF, Yadava A, and Irvine DJ. Enhancing humoral responses to a malaria antigen with nanoparticle vaccines that expand Tfh cells and promote germinal center induction, 109, 1080-5, 2012, PNAS

  • Moon JJ, Suh H, Bershteyn A, Stephan MT, Liu H, Huang B, Sohail M, Luo S, Um SH, Chiu W, and Irvine DJ. Interbilayer-crosslinked multilamellar vesicles for potent humoral and cellular immune responses, 10, 243-251, 2011, Nature Materials

  • Stephan MT, Moon JJ, Um SH, Bershteyn A, and Irvine DJ. Therapeutic cell engineering with surface-conjugated synthetic nanoparticles, 16, 1035-41, 2010, Nature Medicine.

Recent Publications

  • Preety Sahdev; Lukasz J. Ochyl; James J. Moon Biomaterials for Nanoparticle Vaccine Delivery Systems. Pharmaceutical Research. 2014;():
  • Yuchen Fan; Preety Sahdev; Lukasz J. Ochyl; Jonathan J. Akerberg; James J. Moon Cationic liposome-hyaluronic acid hybrid nanoparticles for intranasal vaccination with subunit antigens. Journal of Controlled Release. 2014;():
  • Adrienne V. Li; James J. Moon; Wuhbet Abraham; Heikyung Suh; Jamal Elkhader; Michael A. Seidman; Minmin Yen; Eung-Jun Im; Maria H. Foley; Dan H. Barouch; Darrell J. Irvine Generation of effector memory T cell-based mucosal and systemic immunity with pulmonary nanoparticle vaccination. Science Translational Medicine. 2013;5(204):
  • Mikyung Kim; Likai Song; James Moon; Zhen-Yu J. Sun; Anna Bershteyn; Melissa Hanson; Derek Cain; Selasie Goka; Garnett Kelsoe; Gerhard Wagner; Darrell Irvine; Ellis L. Reinherz Immunogenicity of membrane-bound HIV-1 gp41 membrane-proximal external region (MPER) segments is dominated by residue accessibility and modulated by stereochemistry. Journal of Biological Chemistry. 2013;288(44):31888-31901
  • James J. Moon; Heikyung Suh; Mark E. Polhemus; Christian F. Ockenhouse; Anjali Yadava; Darrell J. Irvine Antigen-displaying lipid-enveloped PLGA nanoparticles as delivery agents for a Plasmodium vivax malaria vaccine. PLoS ONE. 2012;7(2):