Dr. Hongwei Chen is a Research Assistant Professor. He received his PhD in polymer science and engineering in 2005 from the University of Science and Technology of China (USTC), and was a postdoctoral research fellow at USTC (2005-2007), Emory University, in Atlanta, Ga. (2008-2011), and the University of Michigan (2011-2012). His research faculty started as an Assistant Research Scientist in 2012 in the Department of Pharmaceutical Sciences, the University of Michigan College of Pharmacy. He was promoted to Research Assistant Professor in 2018.
His research focuses on understanding the molecular and cellular mechanism of tumor-induced immunosuppression in breast cancer and developing translational nanomedicine-based novel strategy to enhance breast cancer immunotherapy. His current research interest is to find out how tumor-derived exosomes, tiny membrance vesicles (30-100 nm) secreted from cancer cells, regulate the immune cell recruitment, the expression of suppressive proteins on infiltrated immune cells, tumor metastasis, and the antitumor efficacy of immune checkpoint inhibitors. The long-term goal of his research is to develop an effective nanomedicine-based combination strategy to enhance breast cancer immunotherapy.