Summary

Haojie Zhu is an Associate Professor in the Department of Clinical Pharmacy, University of Michigan College of Pharmacy. He graduated from the China Pharmaceutical University with a major in Pharmacy, and further received his M.S. and Ph.D. in Pharmacology from the same University. He also holds an MBA degree from Nanjing University. He was a licensed Pharmacist as well as a trained Dentist in China. Dr. Zhu completed his post-doctoral training in Pharmacogenomics, Pharmacokinetics, and Neuropsychopharmacology at the Medical University of South Carolina. His research focuses on identifying genetic variants and environmental regulators that impact pharmacokinetics and pharmacodynamics of various therapeutic agents using an integrated multi-omics approach (e.g., genomics, proteomics, and metabolomics). The generated information can be used to guide the personalized use of medications to maximize efficacy while minimizing the risk of adverse effects. 

Research Interests

  • Utilize an integrated multi-omics approach combining pharmacogenomics, proteomics, and metabonomics to identify biomarkers associated with interindividual variability in pharmacokinetics and pharmacodynamics

  • Develop innovative LC-MS/MS-based technologies to address the challenges in quantifying proteins and metabolites in complex biomatrices such as blood and solid tissues

Awards

  • 2016 JBC/Herbert Tabor Young Investigator Award, The Journal of Biological Chemistry
  • 2015 AACP New Investigator Award , American Association of Colleges of Pharmacy (AACP)

Selected Publications

  • Genome-wide pQTL analysis of protein expression regulatory networks in the human liver. He B, Shi J, Wang X, Jiang H, Zhu HJ. BMC Biol. 2020 Aug 10;18(1):97. doi: 10.1186/s12915-020-00830-3. PMID: 32778093

     

    Carboxylesterase 1 and Precision Pharmacotherapy: Pharmacogenetics and Nongenetic Regulators. Her L, Zhu HJ. Drug Metab Dispos. 2020 Mar;48(3):230-244. doi: 10.1124/dmd.119.089680. Epub 2019 Dec 23. PMID: 31871135

     

    Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)-Based Proteomics of Drug-Metabolizing Enzymes and Transporters. Li J, Zhu HJ. Molecules. 2020 Jun 11;25(11). doi: 10.3390/molecules25112718. Review. PubMed PMID: 32545386; PMCID: PMC7321193.

     

    Comparative Proteomics Analysis of Human Liver Microsomes and S9 Fractions. Wang X, He B, Shi J, Li Q, Zhu HJ. Drug Metab Dispos. 2020 Jan;48(1):31-40. doi: 10.1124/dmd.119.089235. Epub 2019 Nov 7. PubMed PMID: 31699809; PMCID: PMC6918043.

     

    Label-free absolute protein quantification with data-independent acquisition. He B, Shi J, Wang X, Jiang H, Zhu HJ. J Proteomics. 2019 May 30;200:51-59. doi: 10.1016/j.jprot.2019.03.005. Epub 2019 Mar 14. PMID: 30880166

     

    Functional Study of Carboxylesterase 1 Protein Isoforms. Wang X, Shi J, Zhu HJ. Proteomics. 2019 Feb;19(4):e1800288. doi: 10.1002/pmic.201800288. Epub 2019 Jan 25. PMID: 30520264

     

    Determining Allele-Specific Protein Expression (ASPE) Using a Novel Quantitative Concatamer Based Proteomics Method. Shi J, Wang X, Zhu H, Jiang H, Wang D, Nesvizhskii A, Zhu HJ. J Proteome Res. 2018 Oct 5;17(10):3606-3612. doi: 10.1021/acs.jproteome.8b00620. Epub 2018 Sep 4. PMID: 30141943