Overall Role

To assess in vivo efficacy of a series of novel compounds developed in my laboratory as single-agents and in combination with the standard-of-care chemotherapy for colorectal and pancreatic cancers. Also, to perform in-depth mechanistic studies to better elucidate the mechanism of action of these compounds, develop resistant cell lines, and run RNA-seq and proteomics experiments to identify novel biomarkers. The individual will also be responsible for operation of a specialized lab; develops, designs and conducts one or more large complex research experiments in line with plan; reviews progress and evaluates results. Formulates research methods and suggests options for improving quality, identifies potential problems, recommends and implements solutions; consults with users to refine or adapt methodologies.