Research Interests

  • Antimicrobial Pharmacokinetics/Pharmacodynamics in Obesity.

  • Precision Medicine through Treatment Algorithms that rely on Adaptive Feedback Design

  • Population Pharmacokinetic Systems Analyses to Optimize Drug Dosing in Special Populations

Selected Publications

  • Crass RL, Pai MP. Estimating Renal Function in Drug Development: Time to Take 
the Fork in the Road. J Clin Pharmacol. 2019 Feb;59(2):159-167. 
    Crass RL, Dunn R, Hong J, Krop LC, Pai MP. Dosing vancomycin in the super
obese: less is more. J Antimicrob Chemother. 2018 Nov 1;73(11):3081-3086.
    Crass RL, Rodvold KA, Mueller BA, Pai MP. Renal Dosing of Antibiotics: Are We 
Jumping the Gun? Clin Infect Dis. 2018 Sep 13. doi: 10.1093/cid/ciy790.

     

    Pai MP, Derstine B, Lichty M, Ross B, Sullivan J, Su G, Wang SL.
Relationships of Vancomycin Pharmacokinetics to Body Size and Composition by Computed Tomography Analysis:
A novel "Pharmacomorphomic" approach.
Antimicrob Agents Chemother 2017 24;61(11). pii: e01402-17.

     

    Pai MP. Drug dosing based on weight and body surface area: mathematical assumptions and limitations in obese adults. 
Pharmacotherapy. 2012 Sep;32(9):856-68.

Pai MP, Paloucek FP. The origin of the "ideal" body weight equations. Ann Pharmacother. 2000 Sep;34(9):1066-9.

     

    The 4th edition of Drug Interactions in Infectious Diseases (March 2018) is now available in two volumes