LABORATORY
Haoji Zhu Laboratory
Haojie Zhu, PhD
Haojie Zhu is a Professor in the Department of Clinical Pharmacy, University of Michigan College of Pharmacy. He graduated from the China Pharmaceutical University with a major in Pharmacy, and further received his M.S. and Ph.D. in Pharmacology from the same University. He also holds an MBA degree from Nanjing University. He was a licensed Pharmacist as well as a trained Dentist in China. Dr. Zhu completed his post-doctoral training in Pharmacogenomics, Pharmacokinetics, and Neuropsychopharmacology at the Medical University of South Carolina. His research focuses on identifying genetic variants and environmental regulators that impact pharmacokinetics and pharmacodynamics of various therapeutic agents using an integrated multi-omics approach (e.g., genomics, proteomics, and metabolomics). The generated information can be used to guide the personalized use of medications to maximize efficacy while minimizing the risk of adverse effects.
Lab and Research Overview
- Combining pharmacogenomics, proteomics, and metabolomics with machine-learning to identify biomarkers associated with interindividual variability in pharmacokinetics and pharmacodynamics
- Determining tissue-specific protein expression patterns of prodrug-activating enzymes and applying the information to prodrug design to enhance the activation and accumulation of prodrugs in target tissues
- Developing innovative LC-MS/MS-based technologies to address the challenges in quantifying proteins and metabolites in complex biological matrices such as blood and solid tissues
Lab Members
Logan Smith, PhD
Sunny Jung, PharmD
Hui Yu, MS
Zihan Qin, BS
Yiran Huo, BS
Zeyu Xia, BS
Teaching & Resources
CPTS 824 Proteomics and Metabolomics
CPTS 822 Pharmacogenomics
CPTS 802 Grant Proposal II
PharmSci 704 Analytical Methods
Pharmacy 614 Research and Problem Solving