The objective of the Hertz lab is to develop personalized cancer treatment approaches and translate them into clinical practice to optimize therapeutic outcomes. Our research spans the translational spectrum from discovery through implementation. We identify clinical, genetic, and kinetic predictors of cancer treatment efficacy and/or toxicity in retrospective correlative analyses. These discoveries are integrated into novel tools that inform treatment decisions for the individual patient. These tools can then be tested in prospective clinical trials to demonstrate that personalized cancer treatment enhances efficacy and/or prevents unnecessary toxicity.