DIRECTORY
Pharmaceutical Sciences
Meet the Pharmaceutical Sciences Team
Takahashi, Mariko, PhD
Assistant Research Scientist
Tessier, Peter
Albert M. Mattocks Professor of Pharmaceutical Sciences, College of Pharmacy, and Professor of Chemical Engineering, College of Engineering
Research Topics
The Tessier lab aims to develop best-in-class therapeutic antibodies and apply them to address multiple key biomedical challenges:
1. Conformational antibodies that selectively recognize protein aggregates for detecting and treating neurodegenerative disorders
2. Brain-targeted bispecific antibodies for detecting and treating neurological disorders
3. Agonist antibodies that activate T cells for treating cancer
4. Neutralizing antibodies for treating COVID-19 and other infectious diseases
5. Potent antibody-drug conjugates for treating cancerTo accomplish this, we develop next-generation technologies for designing, discovering, engineering, characterizing, formulating and delivering therapeutic antibodies. Our technology development efforts are focused in three main areas:
1. Protein engineering and directed evolution
2. Biomolecular screening and high-throughput characterization
3. Machine learning and computational predictionsOur interdisciplinary research program uses experimental and computational approaches for generating new fundamental insights into protein structure and function, molecular origins of protein-protein interactions, and molecular determinants of key antibody properties (stability, solubility, specificity and affinity). Our development of novel high-throughput screening and machine learning methods is focused on discovering therapeutic antibody candidates with drug-like properties.